Adachi Motoyasu

Affiliation and department：

Research field (1)： Biophysics

Research theme for competitive and other funds (26)：

2022 - 2027 振電コヒーレント相互作用を用いた光捕集タンパク質増感太陽電池の開発
2021 - 2024 Establishment of method for detecting viral protease activity using affinity competition
2020 - 2023 Development of prediction and evaluation methods of KIE involving drug-metabolizing enzymes for deuterated drug design
2020 - 2023 Development for quantum-theoretical approach by observing hydrogen atom positions in drug target proteins
2018 - 2023 Effects of multiple binding sites of CYP2C9 on its allosteric modulation

2018 - 2021 Development of solar cell sensitized by artificially self-assembled protein using quantum coherent conduction

2016 - 2020 Crystal structure analysis for intermediate in enzymatic reaction by using neutron beam

2016 - 2018 Development of a method to grow large protein crystals for neutron structural analysis

2014 - 2017 Study on Molecular Mechanism in Drug Resistance of Virus Acid Protease

2013 - 2017 Elucidation on pathophysiological significance of orphan P450 expression in tumor tissue and its application to drug discovery research

2011 - 2013 Structural Analysis of Inhibitor Binding Site of Enzyme by Neutron Crystallography

2011 - 2013 Structural and biological studies on metabolism of active oxygen species in medicinal plants

2010 - 2012 Structure-activity relationship studies of CYP2C9 genetic variants

2010 - 2012 Elucidation of Protein-Ligand Interactions Using Neutron Diffraction

2009 - 2011 Elucidation of Activation Mechanism of Extracellular Matrix Protein in Related to Allergosis

2008 - 2010 Investigation of the drug-CYP3A4 interaction by the use of high resolution structure analysis

2007 - 2009 Technological improvement for Neutron Crystallographic Analysis of Protein Structures

2005 - 2006 レトロウイルス由来アスパラギン酸プロテアーゼの中性子構造解析

2005 - 2006 Creation of the Intermolecular Disulfide Bonded Crystal to Observe Tertiary Structures in Different Solvent Conditions

2003 - 2005 Structure-physicochemical property relationships at molecular levels of seed storage proteins

2002 - 2003 ダイズ近縁種を利用する新ダイズ品種の開発基盤の確立

2000 - 2002 Utilization of waste protein from oil seed by improvement for its quality

2000 - 2002 Structure-quality relationships at molecular level of soybean major storage proteins

1998 - 2000 Construction of yeast secretion production system of soybean proteins using mutant strains and their utilization for food

1998 - 1999 ダイズタンパク質グリシニンのX線結晶構造解析と血清コレステロール値低下能の強化

1996 - 1998 Quality-structure relationships of soybean storage proteins

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Papers (72)：

Takeshi Murakawa, Kazuo Kurihara, Mitsuo Shoji, Naomine Yano, Katsuhiro Kusaka, Yoshiaki Kawano, Mamoru Suzuki, Yasuteru Shigeta, Takato Yano, Motoyasu Adachi, et al. Neutron Crystallography of a Semiquinone Radical Intermediate of Copper Amine Oxidase Reveals a Substrate-Assisted Conformational Change of the Peptidyl Quinone Cofactor. ACS Catalysis. 2023. 12403-12413
Shigeki Arai, Rumi Shimizu, Motoyasu Adachi, Mitsuhiro Hirai. Magnetic field effects on the structure and molecular behavior of pigeon iron-sulfur protein. Protein science : a publication of the Protein Society. 2022. 31. 6. e4313
Takeshi Murakawa, Kazuo Kurihara, Motoyasu Adachi, Katsuhiro Kusaka, Katsuyuki Tanizawa, Toshihide Okajima. Re-evaluation of protein neutron crystallography with and without X-ray/neutron joint refinement. IUCrJ. 2022. 9. 3. 342-348
Takeshi Murakawa, Kazuo Kurihara, Mitsuo Shoji, Chie Shibazaki, Tomoko Sunami, Taro Tamada, Naomine Yano, Taro Yamada, Katsuhiro Kusaka, Mamoru Suzuki, et al. Neutron crystallography of copper amine oxidase reveals keto/enolate interconversion of the quinone cofactor and unusual proton sharing. Proceedings of the National Academy of Sciences of the United States of America. 2020. 117. 20. 10818-10824
Arai S, Shibazaki C, Shimizu R, Adachi M, Ishibashi M, Tokunaga H, Tokunaga M. Catalytic mechanism and evolutional characteristics of thioredoxin from Halobacterium salinarum NRC-1. Acta crystallographica. Section D, Biological crystallography. 2020. 76. 1. 73-84

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MISC (74)：

Mikami Bunzo, Adachi Motoyasu, Mizutani Kimihiko, Takahashi Nobuyuki, Kang You-Na, Hirata Akira, Yamane Aiko, Saka Naoki, Kawamura Hirokazu, Hou Xueni, et al. [Review] Crystal Structure Analysis of β-Amylase/Saccharide Complexes Measured at Different pH and Room Temperature. Bulletin of Applied Glycoscience. 2021. 11. 2. 79-86
藤巻秀, 五十嵐龍治, 高草木洋一, 安達基泰, 横谷明徳, 玉田太郎, 河野秀俊, 鹿園直哉, 今岡達彦, 赤松憲, et al. 最先端の研究開発量子科学技術研究開発機構第4回「量子生命科学」の発進. ΑΤΟΜΟΣ. 2019. 61. 6. 477-481
新井栄揮, 柴崎千枝, 安達基泰, 前田宜丈, 田原知幸, 加藤尚志, 宮崎洋, 黒木良太. モルテングロビュールとしてのヒト・トロンボポエチン. 日本蛋白質科学会年会プログラム・要旨集. 2018. 18th
柴崎千枝, 清水瑠美, 新井栄揮, 安達基泰, 黒木良太. プロテインキナーゼの中性子結晶構造解析による分子横断型水素結合ネットワークの観測. 日本中性子科学会年会講演概要集. 2018. 18th
Development of The Cesium Absorption Technique Using Artificially Modified Protein. 2017. 46. 2. 33-40

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Association Membership(s) (8)：

量子生命科学会 , Japanese Society of Enzyme Engineering , THE JAPANESE SOCIETY FOR NEUTRON SCIENCE , THE BIOPHYSICAL SOCIETY OF JAPAN , PROTEIN SCIENCE SOCIETY OF JAPAN , THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS , JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY , THE JAPANESE BIOCHEMICAL SOCIETY

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