2019 - 2024 Stage-specific roles of Notch signaling on induction of T cell development from hematopoietic progenitor cells
2022 - 2024 免疫-脂質代謝の指向性からとらえる肺疾患病態の解明
2020 - 2022 Development of Novel Therapy for Allergic Diseases Using the CRISPR/Cas9 TGA System
2018 - 2020 リポクオリティが制御する脂質リガンドに依存したRORγt機能多様性の解明
2016 - 2019 Elucidation of the mechanism of asthma condition deterioration in the obese environment and the establish of treatment development
2014 - 2019 Elucidation of pathogenic immune memory formation and maintenance
2016 - 2018 炎症性Th17細胞においてRORγtが認識するリポクオリティ分子機構の解明
2012 - 2014 The regulation of memory Th2 cell-dependent allergic airway inflammation through the IL-33-T1/ST2 pathway.
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Papers (67):
Toshio Kanno, Keisuke Miyako, Yusuke Endo. Lipid metabolism: a central modulator of RORγt-mediated Th17 cell differentiation. International immunology. 2024. 36. 10. 487-496
Takahiro Nakajima, Toshio Kanno, Yuki Ueda, Keisuke Miyako, Takeru Endo, Souta Yoshida, Satoru Yokoyama, Hikari K Asou, Kazuko Yamada, Kazutaka Ikeda, et al. Fatty acid metabolism constrains Th9 cell differentiation and antitumor immunity via the modulation of retinoic acid receptor signaling. Cellular & molecular immunology. 2024
Toshio Kanno, Ryo Konno, Masaru Sato, Atsushi Kurabayashi, Keisuke Miyako, Takahiro Nakajima, Satoru Yokoyama, Shigemi Sasamoto, Hikari K Asou, Junichiro Ohzeki, et al. The integration of metabolic and proteomic data uncovers an augmentation of the sphingolipid biosynthesis pathway during T-cell differentiation. Communications biology. 2024. 7. 1. 622-622