Shimamura Munehisa

シマムラムネヒサ | Shimamura Munehisa

Affiliation and department：

Research field (1)： Neurology

Research keywords (7)：神経内科 , 脳梗塞 , 認知症 , パーキンソン病 , 遺伝子治療 , ワクチン , ペプチド創薬

Research theme for competitive and other funds (12)：

2022 - 2025 動脈硬化発症プロセスにおける一酸化窒素修飾がもたらすエンドセリン受容体機能の検討
2021 - 2024 Therapeutic vaccine for senolysis
2020 - 2023 部分再開通における脳梗塞進展の機序解明と治療法の開発
2018 - 2021 Development of novel immunotherapy for chronic inflammatory diseases
2018 - 2021 Investigation of vaccines using glycolipid antigens for anti-aging

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Papers (57)：

Hiroki Hayashi, Jiao Sun, Yuka Yanagida, Takako Otera, Jiayu A. Tai, Tomoyuki Nishikawa, Kunihiko Yamashita, Naoki Sakaguchi, Shota Yoshida, Satoshi Baba, et al. Intradermal administration of DNA vaccine targeting Omicron SARS-CoV-2 via pyro-drive jet injector provides the prolonged neutralizing antibody production via germinal center reaction. Scientific Reports. 2023. 13. 1
Munehisa Shimamura, Chin yang Chang, Hiroki Hayashi, Satoshi Baba, Shota Yoshida, Hironori Nakagami. Impact of insufficient recovery of cerebral blood flow due to partial reperfusion on the pathophysiology of ischemic stroke in mice. Neuroscience Letters. 2023. 810. 137370-137370
Munehisa Shimamura, Hiroki Hayashi, Nan Ju, Shota Yoshida, Satoshi Baba, Tsutomu Sasaki, Hideki Mochizuki, Ryuichi Morishita, Hironori Nakagami. R-spondin 3/LGR4 (Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 4) Axis Is a Novel Inflammatory and Neurite Outgrowth Signaling System in the Ischemic Brain in Mice. Stroke. 2023. 54. 6. 1606-1615
Haomin Yan, Tomohiro Kawano, Hideaki Kanki, Kumiko Nishiyama, Munehisa Shimamura, Hideki Mochizuki, Tsutomu Sasaki. Role of Polymorphonuclear Myeloid-Derived Suppressor Cells and Neutrophils in Ischemic Stroke. Journal of the American Heart Association. 2023. 12. 6. e028125
Yuki Ito, Shuko Takeda, Sayaka Moroi, Tsuneo Nakajima, Akane Oyama, Kunihiro Miki, Nanami Sugihara, Yoichi Takami, Yasushi Takeya, Munehisa Shimamura, et al. Antiepileptic drugs modulate Alzheimer-related tau aggregation in a neuronal activity-independent manner. Dementia and Geriatric Cognitive Disorders. 2023

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MISC (137)：

島村宗尚, 中神啓徳. Development of anti-thrombotic and hypertensive vaccine for prevention of ischemic stroke. 日本血栓止血学会誌. 2021. 32. 3
島村宗尚, 中神啓徳, 森下竜一. 部分再開通における脳梗塞の病態解析. 日本抗加齢医学会総会プログラム・抄録集. 2021. 21st
林宏樹, 孫嬌, 柳田結花, 大寺量子, 塩田達夫, 小野慎子, 松浦善治, 蝶野英人, 峰野純一, 島村宗尚, et al. 新型コロナウイルスをターゲットとしたDNAワクチンの開発. 日本ワクチン学会学術集会プログラム・抄録集. 2021. 25th
Kouji Wakayama, Munehisa Shimamura, Hironori Nakagami, Ryuichi Morishita. The Efficacy of Angiotensin II Peptide Vaccination Against White Matter Lesions of Vascular Dementia in Rats. STROKE. 2020. 51
島村宗尚, 島村宗尚, 鞠楠, 林宏樹, 中神啓徳, 森下竜一. RANKL部分ペプチドMHP1による乾癬に対する治療効果についての検討. 日本抗加齢医学会総会プログラム・抄録集. 2020. 20th

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Education (4)：

2003 - 2005 国立循環器病センター放射線医学部任意研修生
2001 - 2005 大阪大学大学院医学系研究科遺伝子治療学(大学院生)
1991 - 1997 Kumamoto University School of Medicine
- 1991 熊本県立熊本高等学校

Professional career (1)：

医学博士

Work history (12)：

2023/01 - 現在大阪大学大学院医学系研究科遺伝子幹細胞再生治療学寄附講座教授
2015/04 - 現在 Osaka University Graduate School of Medicine
2014/07 - 現在 Osaka University Graduate School of Medicine
2010/04 - 2015/03 大阪大学大学院連合小児発達学研究科健康発達医学講座寄附講座准教授
2009/05 - 2010/03 Osaka University Graduate School of Medicine

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Awards (2)：

2023/06 - 日本抗加齢医学会学会賞新規ペプチド・ペプチドワクチンを用いた画期的な脳梗塞治療・予防法の開発
2022 - 第22回日本抗加齢医学会総会優秀演題賞

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