Rchr
J-GLOBAL ID：201901016242892061
Update date: Sep. 19, 2024
Morimoto Tatsuya
モリモト タツヤ | Morimoto Tatsuya
Affiliation and department：
Other affiliations (2)：
Research field (4)：
Food sciences
, Cardiology
, Pharmaceuticals - health and biochemistry
, Pharmacology
Research keywords (11)：
ハイスル-プット スクリーニング
, Glioma
, Brain tumor
, 心保護
, 機能性食品
, GATA4
, 天然物
, p300
, ヒストンアセチル化
, 心筋細胞肥大
, 心不全
Research theme for competitive and other funds (11)：
- 2023 - 2026 The studyon of p300 complex on cardiac hypertrophy and fibrosis during the development of heart failure
- 2023 - 2026 ノックインマウスを用いた心不全によるGATA4多量体形成の変化並びに治療薬の探索研究
- 2020 - 2023 Identification and functional analysis of p300 regulatory factors involved in the development of heart failure using medical proteomics
- 2020 - 2022 Roles of sex chromosomes in pathophysiological sex difference formation in the heart
- 2017 - 2020 Investigation of novel heart failure therapy targeting transcription complex
- 2015 - 2018 Novel heart failure pharmacotherapy that targets nuclear signaling pathway in cardiac myocytes
- 2014 - 2017 Identifying the novel therapeutic targets by investigating the regulatory mechanism of transcription complex during the development of heart failure
- 2009 - 2011 Analysis of activation mechanism of cardiac p300/GATA4 pathway during heart failure
- 2007 - 2008 Purification and analysis of a transoription factor, GATA4 complex from adult mouse heart during developing heart failure
- 2005 - 2006 Analysis of cardiac specific transcription factor GATA-4 complex during differentiation of mouse embryonic stem cells into cardiac myocytes
- 2004 - 2005 Identification of intracellular signaling molecules that bind to cardiac p300 during the development of heart failure and its application to pharmacological therapy
Show all
Papers (259)：
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Yasufumi Katanasaka, Harumi Yabe, Noriyuki Murata, Minori Sobukawa, Yuga Sugiyama, Hikaru Sato, Hiroki Honda, Yoichi Sunagawa, Masafumi Funamoto, Satoshi Shimizu, et al. Fibroblast-specific PRMT5 deficiency suppresses cardiac fibrosis and left ventricular dysfunction in male mice. Nature communications. 2024. 15. 1. 2472-2472
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山本 みずほ, 砂川 陽一, 上原 渉, 船本 雅文, 刀坂 泰史, 浜辺 俊秀, 川瀬 裕斗, 鳴田 竜也, ホーク フィリップ, 小見山 麻紀, et al. A485, a Small Molecule Inhibitor of p300/CBP Histone Acetyltransferase, Ameliorates Pressure Overload-induced Cardiac Dysfunction in Mice(タイトル和訳中). 日本循環器学会学術集会抄録集. 2024. 88回. PJ098-4
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川瀬 裕斗, 砂川 陽一, 船本 雅文, 刀坂 泰史, 浜辺 俊秀, 長谷川 浩二, 森本 達也. 6-shogaol, a Ginger Extract, Improves Pressure Overload-induced Systolic Dysfunction through the Inhibition of p300-HAT Activity(タイトル和訳中). 日本循環器学会学術集会抄録集. 2024. 88回. PJ101-6
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Yoichi Sunagawa, Ryosuke Tsukabe, Yudai Irokawa, Masafumi Funamoto, Yuto Suzuki, Miho Yamada, Satoshi Shimizu, Yasufumi Katanasaka, Toshihide Hamabe-Horiike, Yuto Kawase, et al. Anserine, a Histidine-Containing Dipeptide, Suppresses Pressure Overload-Induced Systolic Dysfunction by Inhibiting Histone Acetyltransferase Activity of p300 in Mice. International Journal of Molecular Sciences. 2024. 25. 4. 2344-2344
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Swati Mittal, Maki Komiyama, Yuka Ozaki, Hajime Yamakage, Noriko Satoh-Asahara, Hiromichi Wada, Akihiro Yasoda, Masafumi Funamoto, Yasufumi Katanasaka, Yoichi Sunagawa, et al. Impact of smoking initiation age on nicotine dependency and cardiovascular risk factors: a retrospective cohort study in Japan. European heart journal open. 2024. 4. 1. oead135
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MISC (630)：
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川瀬裕斗, 砂川陽一, 砂川陽一, 砂川陽一, 船本雅文, 船本雅文, 刀坂泰史, 刀坂泰史, 刀坂泰史, 浜辺俊秀, et al. 6-shogaol, a Ginger Extract, Improves Pressure Overload-induced Systolic Dysfunction through the Inhibition of p300-HAT Activity. 日本循環器学会学術集会(Web). 2024. 88th
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山本みずほ, 砂川陽一, 砂川陽一, 砂川陽一, 上原渉, 船本雅文, 船本雅文, 刀坂泰史, 刀坂泰史, 刀坂泰史, et al. A485, a Small Molecule Inhibitor of p300/CBP Histone Acetyltransferase, Ameliorates Pressure Overload-induced Cardiac Dysfunction in Mice. 日本循環器学会学術集会(Web). 2024. 88th
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須藤優, 高井秀通, 砂川陽一, 砂川陽一, 砂川陽一, 船本雅文, 船本雅文, 川瀬裕斗, 鳴田竜也, 刀坂泰史, et al. The novel Curcumin formulation curcuRouge inhibits systolic dysfunction in myocardial infarction model rats. 日本薬学会年会要旨集(Web). 2024. 144th
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鈴木悠斗, 森本達也, 森本達也, 森本達也, 砂川陽一, 砂川陽一, 砂川陽一, 船本雅文, 船本雅文, 前川健也, et al. Extract from Sprout of Polygonum Sachalinense Suppressed Systolic Dysfunction after Myocardial Infarction. 日本薬学会年会要旨集(Web). 2024. 144th
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色川雄大, 砂川陽一, 砂川陽一, 砂川陽一, 山田美帆, 片桐宇大, 前川健也, 清水聡史, 清水聡史, 刀坂泰史, et al. ヒスチジン含有ジペプチドであるアンセリンは心筋細胞肥大および圧負荷モデルマウスの心収縮能低下を抑制した. 日本循環薬理学会口演要旨集. 2024. 33rd
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Patents (7)：
Education (2)：
- 1996 - 2000 京都大学大学院 医学研究科
- 1986 - 1992 Kyoto University Faculty of Medicine
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