Ui-Tei Kumiko

Ui-Tei Kumiko | Ui-Tei Kumiko

Affiliation and department：
Other affiliations (4)：

The University of Tokyo Graduate School of Science
The University of Tokyo
Tokyo University of Science
株式会社ANRis CTO兼技術顧問

Homepage URL (1)： http://ui-tei.rnai.jp/

Research field (3)： Genomics , Biological, health, and medical informatics , Molecular biology

Research keywords (16)：生物情報科学 , Genome biology , RNA interference , Nucleic acid therapeutics , microRNA , gene network , heredity disease , multilevel regulation , spacio-temporal gene expression regulation , single nucleotide mutation , がんゲノム医療 , SNPD-siRNA , KRAS , CRISPR/Cas9 , siRNA , Genome editing

Research theme for competitive and other funds (57)：

2023 - 2026 希少難病に対するN-of-1+核酸医薬創薬研究
2021 - 2026 Establishment of a basis of non-clinical test for the practical application of SNPD-siRNA that suppresses only mutant gene without affecting the function of wild-type genes
2021 - 2026 Development of optimizing method on the treatment of refractory ovarian cancer by combining newly modified siRNA and nucleic acid delivery systemy
2022 - 2025 動物試験で検出困難な毒性を予測するオフターゲット評価法の確立 -リスク分子にフォーカスしたターゲットプロテオミクス解析- Establishment of an Off-target Evaluation System for Crucial risk Associated molecules using targeted ProtEomics (Off-ESCAPE)
2021 - 2024 ヒト高次脳機能におけるmicroRNAを介した遺伝子ネットワークの解明

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Papers (116)：

Keiko Shibata, Harune Moriizumi, Koji Onomoto, Yuka Kaneko, Takuya Miyakawa, Shuhei Zenno, Masaru Tanokura, Mitsutoshi Yoneyama, Tomoko Takahashi, Kumiko Ui-Tei. Caspase-mediated processing of TRBP regulates apoptosis during viral infection. Nucleic Acids Research. 2024
Shohei Maruyama, Takashi Kusakabe, Xinyi Zou, Yoshiaki Kobayashi, Yoshimasa Asano, Qingbo S. Wang, Kumiko Ui-Tei. SNPD-CRISPR: Single Nucleotide Polymorphism-Distinguishable Repression or Enhancement of a Target Gene Expression by CRISPR System. Methods in Molecular Biology. 2023. 49-62
Qingbo S. Wang, Kumiko Ui-Tei. Utilizing Large Functional and Population Genomics Resources for CRISPR/Cas Perturbation Experiment Design. Methods in Molecular Biology. 2023. 63-73
小林芳明, 浅野吉政, 程久美子. siRNAが働く仕組みと医薬品としての研究開発の現状. 循環器内科. 2023. 93. 1-9
Fangjie L, An S, Kobayashi Y, Nomura K, Baba R, Abe N, Hiraoka H, Hashiya F, Shu Z, Ui-Tei K, et al. A 2'-modified uridine analog, 2'-O-(methylthiomethoxy)methyl uridine, for siRNA applications. Bioorganic & Medicinal Chemistry Letters. 2022. 128939-128939

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MISC (48)：

小林芳明, 浅野吉政, 程久美子. siRNAが働く仕組みと医薬品としての研究開発の現状-Mechanisms of RNA interference and the current status of research and development of siRNA drugs. 循環器内科 = Cardioangiology / 循環器内科編集委員会編. 2023. 93. 3. 346-354
大山隼礼, 小林芳明, 浅野吉政, 合山進, 程久美子, 程久美子. Development of siRNA specific for PIK3CA proto-oncogene with single-nucleotide mutation and its effect on cancer cell proliferation. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
小野隆一, 小林芳明, 程久美子, 程久美子. Development of a CRISPR-Cas9 system that targets only harmful bacteria or metabolites in human gut microbiota. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
小林芳明, 浅野吉政, 谷口博昭, 程久美子. Development and characterization of SNPD-siKRAS which specifically represses KRAS gene with single nucleotide mutation. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
湯之前拓, 松井宏睦, 小林芳明, 程久美子, 程久美子. Development of a CRISPR system that distinguishes single nucleotide mutations in the TERT promoter to suppress carcinogenesis. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th

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Patents (17)：

WRNへリカーゼ遺伝子を標的とするsiRNA
RecQL1ヘリカーゼ遺伝子を標的とするsiRNA
RNA分子
RNA分子、キメラ型NA分子、二本鎖RNA分子、および二本鎖キメラ型NA分子
ANTIVIRAL SILENCING RNA MOLECULES, CHEMICALLY MODIFIED ANTIVIRAL SILENCING RNA MOLECULES WITH ENHANCED CELL PENETRATING ABILITIES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AND USES THEREOF FOR TREATMENT OF VIRAL INFECTIONS

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Books (55)：

1塩基を標的としたsiRNA医薬をがんと遺伝性疾患に開発するANRis
2024
新薬開発に低分子RNA、東大発スタートアップが事業化する技術とは?
ニュースイッチ by 日刊工業新聞社 2023
siRNA核酸医薬品の研究開発動向と実用化へ向けた今後の展開
PHARM STAGE 23、65-72、(株)技術情報協会 2023
核酸医療の基礎知識:mRNAの発現制御機構ーsiRNAとmiRNAの比較ー
CLINICAL NEUROSICENCE、616-620、(株)中外医学社 2023
Oligonucleotide Therapeutics and mRNA Therapeutics:Fundamentals for CMC and Basic Technology Development
2023

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Professional career (1)：

理学博士

Work history (11)：

2024/04 - 現在 Tokyo Medical and Dental University
2024/04 - 現在 Tokyo University of Science
2024/04 - 現在 The University of Tokyo
2024/04 - 現在 The University of Tokyo Graduate School of Science
2023/11 - 現在株式会社ANRis CTO兼技術顧問

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Committee career (5)：

2017 - 現在 Genes(Basel) Editorial Board
2016 - 現在日本核酸医薬学会評議員
2015 - 現在 PLoS ONE Editorial Board
2014 - 現在 Frontiers in Genetics Editorial board
2022/04 - 2024/03 日本核酸医薬学会生物セッション主任幹事

Awards (6)：

2023/03 - 統括所長柴山知也【基礎力養成編】
2022/09 - Boehringer Ingelheim Boehringer Ingelheim Innovation Prize "Development and commercialization of siRNAs that suppress only disease-causing genes with single nucleotide mutations."
2022 - Addgene (NPO) Blue Flame Award,
2019/07 - NUCLEIC ACIDS THERAPEUTICS SOCIETY OF JAPAN Academic prize
2004 - Oxford University Press Award. Top web server issue paper 2004, Nucleic Acids Research

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Association Membership(s) (6)：

日本癌学会 , Oligonucleotide Therapeutic Society , THE JAPANESE SOCIETY FOR IMMUNOLOGY , THE RNA SOCIETY OF JAPAN , NUCLEIC ACIDS THERAPEUTICS SOCIETY OF JAPAN , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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