Research keywords (4)：
chromosome engneering
, chromosome
, tumor biology
, cancer
Research theme for competitive and other funds (5)：
2021 - 2024 Identification of a novel drug resistance mechanism in melanoma cells
2018 - 2020 PITX1を標的とした新規メラノーマ治療戦略
2015 - 2017 Identification of hTERT supressor genes located on human choromosome 3
2015 - 2017 Studies of the molecular mechanisms in the regulation of telomerase activity and cell immortarization
2013 - 2015 新規がん抑制遺伝子の機能解析から解き明かすテロメレース発現制御ネットワーク
Papers (20)：
Takahito Ohira, Kaho Yoshimura, Hiroyuki Kugoh. Human artificial chromosome carrying 3p21.3-p22.2 region suppresses hTERT transcription in oral cancer cells. Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology. 2023. 31. 3. 17-17
Ryutaro Shimizu, Takahito Ohira, Takuki Yagyu, Tetsuya Yumioka, Noriya Yamaguchi, Hideto Iwamoto, Shuichi Morizane, Katsuya Hikita, Masashi Honda, Atsushi Takenaka, et al. Activation of PPARγ in bladder cancer via introduction of the long arm of human chromosome 9. Oncology Letters. 2022. 23. 3
Mizuho Ishikawa, Mitsuhiko Osaki, Narumi Uno, Takahito Ohira, Hiroyuki Kugoh, Futoshi Okada. MTA1, a metastasis-associated protein, in endothelial cells is an essential molecule for angiogenesis. Molecular medicine reports. 2022. 25. 1
Ohira T, Nakagawa S, Takeshita J, Aburatani H, Kugoh H. PITX1 inhibits the growth and proliferation of melanoma cells through regulation of SOX family genes. 2021. 15;11(1):18405
