2017 - 2020 Analysis of EV encapsulated long non-coding RNA as the liquid biopsy for pancreatic cancer
2017 - 2020 Analysis of the mechanism of tumor microenvironment modulation through exosomes in hepatocellular cancer stem cells
2016 - 2019 Elucidation of the association between non alcoholic steatohepatitis and endoplasmic reticulum stress by metabolomics of portal blood
2016 - 2017 C型肝炎持続感染に起因する肝発癌機構解明とバイオマーカーの同定
2013 - 2016 amino acids metabolism and immune abnormality in non alcoholic steatohepatitis
2013 - 2016 Development of HCC treatment by analyzing the induction of MDSC, TAM and Tregs
2013 - 2016 Exosomal transfer of functional RNA in hepatocellular carcinoma cell proliferation
2007 - 2008 Liver Cancer stem cells and chemotherapeutic resistance
2005 - 2006 Extracellular Branched-chain Amino Acids, Especially Valine, Regulate Maturation and Function of Monocyte-derived Dendritic Cells
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Papers (82)：
Masaaki Mino, Akitoshi Sano, Eiji Kakazu, Hiroko Matsubara, Keisuke Kakisaka, Takayuki Kogure, Katsunori Sekine, Yoshihiko Aoki, Masatoshi Imamura, Michitaka Matsuda, et al. Differences in branched-chain amino acid to tyrosine ratio (BTR) among etiologies of chronic liver disease progression compared to healthy adults. Journal of gastroenterology. 2024
Akinobu Koiwai, Morihisa Hirota, Keigo Murakami, Tomofumi Katayama, Ryo Kin, Katsuya Endo, Takayuki Kogure, Atsuko Takasu, Hiroto Sakurai, Noriko Kondo, et al. Direct peroral cholangioscopy with red dichromatic imaging 3 detected the perihilar margin of superficial papillary extension in a patient with intraductal papillary neoplasm of the bile duct. DEN open. 2023. 3. 1. e228
Morihisa Hirota, Keigo Murakami, Akinobu Koiwai, Keita Kawamura, Yuki Yoshino, Atsuko Takasu, Ryo Kin, Tomofumi Katayama, Katsuya Endo, Takayuki Kogure, et al. Neutrophil Infiltration and Acinar-ductal Metaplasia are the Main Pathological Findings in Pembrolizumab-induced Pancreatitis: A Case Report. Internal medicine (Tokyo, Japan). 2022. 61. 24. 3675-3682
Akinobu Koiwai, Morihisa Hirota, Tomofumi Katayama, Ryo Kin, Keita Kawamura, Katsuya Endo, Takayuki Kogure, Atsuko Takasu, Takayoshi Meguro, Kennichi Satoh. Self-expandable metal stents have longer patency and less cholangitis than inside stents in malignant perihilar biliary obstruction. JGH open : an open access journal of gastroenterology and hepatology. 2022. 6. 5. 317-323
Mari Satoh, Takayuki Kogure, Akinobu Koiwai, Daisuke Fukushi, Morihisa Hirota, Katsuya Endo, Kennichi Satoh. A Gas-forming Liver Abscess with Massive Bleeding into the Abscess Cavity Due to a Ruptured Inferior Phrenic Artery. Internal Medicine. 2021. 60. 24. 3913-3919
Mari Satoh, Takayuki Kogure, Takehito Ito, Masanori Takahashi, Ryusuke Ouchi, Kensuke Usui, Kouji Okada, Kennichi Satoh. MICRORNA-491-5p IS INVOLVED IN THE RESISTANCE TO LENVATINIB INDUCED UNDER HYPOXIA IN HEPATOCELLULAR CARCINOMA. HEPATOLOGY. 2021. 74. 702A-702A
2000 - 2004 Tohoku University Graduate School of Medicine Gastroenterology
1991 - 1997 Tohoku University School of Medicine
1988 - 1991 Gumma Prifectural Maebashi High School
Professional career (1)：
博士(医学) (東北大学)
Work history (8)：
2022/04 - 現在 Tohoku Medical and Pharmaceutical University Division of Gastroenterology Associate Professor
2017/04 - 2022/03 Tohoku Medical and Pharmaceutical University Division of Gastroenterology Assistant Professor
2012/01 - 2017/03 Tohoku University Gastroenterology Assistant Professor
2011/01 - 2011/12 Mayo Clinic Cancer Center Postdoctoral Researcher
2008/11 - 2010/12 The Ohio State University Wexner Medical Center Postdoctoral Researcher
2005/04 - 2008/10 Tohoku University Gastroenterology Clinical Fellow
2004/04 - 2005/03 Osaki Citizen Hospital Gastroenterology Vice Director
1997/04 - 2000 Iwate Prefectural Kitakami Hospital Internal Medicine Residency
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Committee career (5)：
2018/06 - 現在 アメリカ肝臓病学会議 (AASLD) フェロー
2018 - 現在 日本消化器病学会 評議員
2014/04 - 現在 宮城県対がん協会 肝胆膵疾患診断委員会委員
2014 - 現在 日本肝臓学会 東部会 評議員
2013 - 現在 日本消化器病学会 東北支部 評議員
Awards (6)：
2015 - 日本肝臓学会 研究奨励賞 Involvement of miRNA-29a in epigenetic regulation of transforming growth factor-β-induced epithelial-mesenchymal transition in hepatocellular carcinoma.
2011 - The American Association for the Study of Liver Diseases (AASLD) Distinguished Poster Inter-cellular nanovesicle mediated microRNA transfer: a mechanism of environmental modulation of hepatocellular cancer cell growth.
2002 - 日本肝臓学会 国際学会参加に伴う費用の一部助成 The cytotoxic effects of a combination of 5-fluorouracil, cisplatin, and leucovorin on human hepatoma cells are influenced by the key catalyzing enzymes.
The Japan Society for transplantation
, The Japan Society of Hepatology
, The Japanese Society of Gastroenterology
, The Japanese Society of Internal Medicine
, American Association for Cancer Research (AACR)
, The American Association for the Study of Liver Diseases (AASLD)
