Aki Koike

コイケアキ | Aki Koike

Affiliation and department：

Research field (7)： Cell biology , Molecular biology , Environmental effects of chemicals , Environmental effects of radiation , Tumor biology , Tumor diagnostics and therapeutics , Veterinary medicine

Research keywords (9)：分子細胞生物学 , マウス , ネコ , イヌ , 伴侶動物 , DNA損傷応答 , 抗がん剤 , DNA修復 , 重粒子線がん実験治療

Research theme for competitive and other funds (5)：

2022 - 2025 伴侶動物の革新的がん治療法開発に向けた次世代型重粒子線増感がん治療薬開発基盤研究
2014 - 2017 Biological function of aryl hydrocarbon receptor in colon cancer
2014 - 2017 伴侶動物のDNA二本鎖切断修復の分子機構に基づく新しい放射線増感剤の開発基盤研究
2012 - 2015 A paradigm shift by two Ku80: New model of the radiation-induced DNA damage response mechanism in human cells
2008 - 2010 Development of a novel DNA damage sensor mouse model.

Papers (39)：

小池学, 小池亜紀. 伴侶動物の革新的がん治療法開発のための次世代重粒子線増感がん治療薬の開発に向けた基礎研究. Precision Medicine. 2024. 7. 2. 60-62
Manabu Koike, Hideji Yamashita, Yasutomo Yutoku, Aki Koike. Molecular cloning, subcellular localization, and rapid recruitment to DNA damage sites of chicken Ku70. Scientific Reports. 2024. 14. 1
Hirofumi Fujimoto, Togo Ikuta, Aki Koike, Manabu Koike. Acetylation of the nuclear localization signal in Ku70 diminishes the interaction with importin-α. Biochemistry and biophysics reports. 2023. 33. 101418-101418
Manabu Koike, Yasutomo Yutoku, Aki Koike. Feline XRCC4 undergoes rapid Ku-dependent recruitment to DNA damage sites. FEBS Open Bio. 2022. 12. 4. 798-810
Manabu KOIKE, Yasutomo YUTOKU, Aki KOIKE. Combined ataxia telangiectasia mutated and DNA-dependent protein kinase inhibition radiosensitizes Madin-Darby canine kidney cells. Journal of Veterinary Medical Science. 2022. 84. 11. 1485-1490

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MISC (6)：

伊吹裕子, 豊岡達士, 小池亜紀, 小池学. Imaging of the behavior of DNA double strand break damage by radiation and DNA repair enzyme. 放射線科学. 2005. 48. 9
KOIKE Manabu, KOIKE Aki. 106 Effects of Point Mutations in Ku80 Proteins on Ku-dependent DNA Repair(Repair of radiation damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society) :. Journal of radiation research. 2003. 44. 4. 412-413
KOIKE Manabu, KOIKE Aki. Mammalian cell lines expressing functional Ku80- and its mutants-tagged with the green fluorescent protein :. Journal of radiation research. 2002. 43. 4. 450-450
KOIKE Manabu, KOIKE Aki, SHIOMI Tadahiro. Differential Subcellular Localization of DNA-Dependent Protein Kinase Components Ku and DNA-PKcs during Mitosis :. Journal of radiation research. 2000. 41. 4. 394-394
M Koike, T Ikuta, T Miyasaka, A Koike, T Shiomi. The nuclear localization signal of the human Ku70 is a variant bipartite type recognized by the two components of nuclear pore-targeting complex. MOLECULAR BIOLOGY OF THE CELL. 1999. 10. 286A-286A

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