Nakayama Atsushi

ナカヤマアツシ | Nakayama Atsushi

Affiliation and department：
Job title： Associate Professor

Research field (1)： Pharmaceuticals - chemistry and drug development

Research keywords (5)： biosynthesis , chemical biology , medicinal chemistry , natural product chemistry , synthetic organic chemistry

Research theme for competitive and other funds (7)：

2024 - 2026 Development of the latent chemical space based on the divergent synthesis of macrocyclic natural and pseudo-natural products
2023 - 2026 がん細胞被認識強化をもたらす未知生体内標的分子の同定と創薬基盤の構築
2020 - 2023 多発性骨髄腫克服を目指した共有結合性官能基含有治療薬の開発研究
2019 - 2022 Elucidation of the molecular mechanism of the innovative fertilizer that greens the desert: unknown function search of phytosiderophore
2017 - 2020 骨改善作用を併せ持つ新規多発性骨髄腫治療薬の創製研究

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Papers (56)：

Seigo Yumura, Daisuke Kitagawa, Kei Moritsugu, Atsushi Nakayama, Tetsuro Shinada, Masaaki Sawa, Takayoshi Kinoshita. Conserved gatekeeper methionine regulates the binding and access of kinase inhibitors to ATP sites of MAP2K1, 4, and 7: Clues for developing selective inhibitors. Bioorganic & Medicinal Chemistry Letters. 2024. 129914-129914
Eigo Fukuda, Ibuki Fujiwara, Shoki Maruno, Kaiki Motomura, Seiya Endo, Arihiro Iwasaki, Tatsuya Fukuta, Atsushi Nakayama, Tetsuro Shinada. Total Synthesis of Bipenicilisorin and Assignment of the Absolute Configuration. Journal of Natural Products. 2024. 87. 5. 1394-1400
Atsushi Nakayama. Studies on Comprehensive Total Synthesis of Natural and Pseudo-Natural Products for Drug Discovery. Chemical and Pharmaceutical Bulletin. 2024. 72. 5. 422-431
Natsumi Kozakai, Seiya Endo, Atsushi Nakayama, Riku Horinouchi, Makoto Yoshida, Masayoshi Arai, Tetsuro Shinada. First Total Syntheses of Beauvericin A and allo-Beauvericin A. ACS Omega. 2024. 9. 10. 12228-12236
Ryosuke Tanaya, Takeshi Kodama, Juthamart Maneenet, Yoko Yasuno, Atsushi Nakayama, Tetsuro Shinada, Hironobu Takahashi, Takuya Ito, Hiroyuki Morita, Suresh Awale, et al. Substrate-Dependent Alteration in the C- and O-Prenylation Specificities of Cannabis Prenyltransferase. Biological and Pharmaceutical Bulletin. 2024. 47. 2. 449-453

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MISC (16)：

山本璃子, 長野秀嗣, 米良茜, KARANJIT Sangita, 中山淳, 辻大輔, 辻大輔, 赤木玲子, 伊藤孝司, 難波康祐. Synthesis of 1,3a,6a-Triazapentalene derivatives and evaluation of those photoresponsive cytotoxicity. 日本薬学会年会要旨集(Web). 2023. 143rd
木村有希, 大橋栄作, SANGITA Karanjit, 中山淳, 難波康祐. Total synthesis of guaianolide-type sesquiterpene lactones. 日本薬学会年会要旨集(Web). 2022. 142nd
木村有希, 大橋栄作, 迫頭春子, 中山淳, 難波康祐. Total synthesis of guaianolide-type sesquiterpene lactones. 日本薬学会年会要旨集(Web). 2021. 141st
木村有希, 大橋栄作, 中山淳, SANGITA Karanjit, 難波康祐. Guaianolide型セスキテルペンラクトン類の全合成. 創薬懇話会講演要旨集. 2021. 2021
船曵早希, 佐々木彩花, 向山はるか, 辻大輔, 村田佳子, 山本武範, SANGITA Karanjit, 中山淳, 伊藤孝司, 難波康祐. イネ科植物の鉄イオン取り込み機構解明のためのトランスポーター標識プローブの開発. 創薬懇話会講演要旨集. 2021. 2021

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Patents (3)：

新規イノン化合物及びその用途
新規イノン化合物及びその用途
蛍光色素を用いた歯周病の簡易検査

Books (1)：

Equilibrium-Controlled Stereoselective Sequential Cyclizations Enabled Concise Total Synthesis of Complex Indole Alkaloid, Tronocarpine
Springer 2023 ISBN:9789819917136

Lectures and oral presentations (35)：

(+)-Eurotiumide Fおよび(+)-eurotiumide Gの不斉全合成と構造訂正
(第58回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会 2019)
天然物の網羅全合成を基軸とした医薬化学研究とケミカルバイオロジー
(第189回薬学談話会 (名古屋市立大学) 2019)
Resorcylic Acid Lactonesを基盤とした新規骨髄腫治療薬の創製研究
(第45回反応と合成の進歩シンポジウム 2019)
Synthetic Studies on Chipiine-type alkaloids
(27ht International Society of Heterocyclic Chemistry Congress 2019)
天然物の網羅全合成を基軸とした医薬化学研究
(第54回天然物化学談話会 2019)

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Professional career (1)：

Ph.D (Chiba University)

Work history (8)：

2024/07 - 現在 Graduate School of Pharmaceutical Sciences, Osaka University Associate Professor
2022/04 - 2024/07 Graduate School of Science, Osaka Metropolitan University
2020/10 - 2022/03 Osaka City University Graduate School of Science Lecturer
2014/06 - 2020/09 Tokushima University Graduate School of Pharmaceutical Sciences assistant professor
2012/05 - 2014/05 The Scripps Research Institute POstdoctral Researcher

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Committee career (3)：

2023/05 - 現在日本薬学会次世代シンポジウム世話人
2014/07 - 現在天然物化学談話会天然物談話会世話人
2017/04 - 2019/03 日本薬学会ファルマシアトピックス小委員

Awards (8)：

2023/07 - 大阪公立大学 2023年度大阪公立大学若手研究者奨励賞
2022/03 - The Pharmaceutical Society of Japan The Pharmaceutical Society of Japan Award for Young Scientists
2020/07 - The Pharmaceutical Society of Japan Division of Natural Medicines Young Investigator Award of The Pharmaceutical Society of Japan Division of Natural Medicine
2019/09 - Young Scientist's Research Award in Natural Product Chemistry
2018/12 - Tokushima University Young Investigator Award in Tokushima University

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Association Membership(s) (6)：

日本農芸化学会 , 日本ケミカルバイオロジー学会 , 日本化学会 , THE SESSILE ORGANISMS SOCIETY OF JAPAN , THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN , THE PHARMACEUTICAL SOCIETY OF JAPAN

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