Research field (7)：
Physiology
, Cell biology
, Pharmacology
, Respiratory medicine
, Nephrology
, Clinical pharmacy
, Pharmaceuticals - health and biochemistry
Research theme for competitive and other funds (3)：
2023 - 2026 脳機能の改善を目指した脳室上衣線毛運動の活性化物質の探索と調節機構の解明
2021 - 2025 Cytoskeleton-associated proteins in mucus lineage clearance.
2018 - 2020 Role of moesin in endocytosis of NKCC2 and in Bartter's syndrome.
Papers (20)：
Kotoku Kawaguchi, Sakura Yokoyama, Haoting Wang, Shinji Asano. Inhibition of ezrin phosphorylation by NSC305787 attenuates procaterol-stimulated ciliary beating in airway cilia. Biochemical and Biophysical Research Communications. 2024. 703. 149685-149685
Takashi Nakahari, Chihiro Suzuki, Kotoku Kawaguchi, Shigekuni Hosogi, Saori Tanaka, Shinji Asano, Toshio Inui, Yoshinori Marunaka. Ambroxol-Enhanced Frequency and Amplitude of Beating Cilia Controlled by a Voltage-Gated Ca2+ Channel, Cav1.2, via pHi Increase and [Cl-]i Decrease in the Lung Airway Epithelial Cells of Mice. International Journal of Molecular Sciences. 2023. 24. 23. 16976-16976
Tomomi Nishie, Yoshio Ohta, Emi Shirai, Shogo Higaki, Nobuhiro Shimozawa, Keishi Narita, Kotoku Kawaguchi, Hideyuki Tanaka, Chika Mori, Taiga Tanaka, et al. Identification of TEKTIN1-expressing multiciliated cells during spontaneous differentiation of non-human primate embryonic stem cells. Genes to Cells. 2023. 28. 7. 516-525
Saitoh D, Suzuki C, Tanaka S, Hosogi S, Kawaguchi K, Asano S, Okamoto S, Yasuda M, Hirano S, Inui T, et al. Ambroxol-enhanced ciliary beating via voltage-gated Ca2+ channels in mouse airway ciliated cells. European Journal of Pharmacology. 2023. 941. 175496. 175496-175496
Hirao T, Kim BG, Habuchi H, Kawaguchi K, Nakahari T, Marunaka Y, Asano S. Transforming Growth Factor-β1 and Bone Morphogenetic Protein-2 Inhibit Differentiation into Mature Ependymal Multiciliated Cells. Biological and Pharmaceutical Bulletin. 2023. 46. 1. 111-122
Importance of ultrastructure in SARS-CoV-2 infection in airway epithelium. Farumashia. 2022. 58. 11. 1081-1081
Failure of NHE3-containing macro-complexes in the intestine causes diabetic diarrhea. Farumashia. 2016. 52. 4. 346-346
Books (2)：
生理学用語ハンドブック
丸善出版 2024 ISBN:9784621309087
病態生理からひもとく水・電解質異常
株式会社メヂカルフレンド社 2021
Lectures and oral presentations (7)：
Roles of Ezrin in regulation of ciliary beating in lung multiciliated cell.
(Cold Spring Harbor Asia Conference on Cilia & Centrosomes 2023 2023)
Roles of ezrin on the morphogenesis and regulation of movement of airway cilia
(Experimental Biology 2021 2021)
Endocytosis of NKCC2 is impaired in renal tubule in moesin knockout mice
(9th FAOPS (Federation of Asia and Oceania Perinatal Societies) Congress (2019) 2019)
Endocytosis of NKCC2 is impaired in renal tubule in moesin knockout mice.
(Europhysiology 2018 2018)
Impaired Renal Electrolyte Reabsorption in Moesin-Deficient Mice.
(American Society of Nephrology (ASN) Kidney Week 2016 2016)
Japanese Association for Oral Biology
, The Japanese Pharmacological Society
, American Society of Nephrology
, American Physiological Society
, 日本生化学会
, The Pharmaceutical Society of Japan
, The Physiological Sciety of Japan
