Kuba Keiji

Affiliation and department：
Homepage URL (1)： http://kuba-lab.com/

Research field (1)： Pharmacology

Research keywords (14)： tumor heterogeneity , Galectin-7 , acute respiratory distress syndrome , heart failure , SARS-CoV-2 , TLR4 , Protectin D1 , NPY , RNAメチル化 , RNA分解 , CNOT3 , CCR4-NOT複合体 , Apelin , アンジオテンシン変換酵素2 (ACE2)

Research theme for competitive and other funds (15)：

2022 - 2025 癌の転移・再発における細胞外Galectin-Xを介した免疫抑制機構の解明
2021 - 2024 自然リンパ球特異的mRNA代謝による病態制御機構の解明
2020 - 2023 食道癌リンパ節転移を支配する決定的なRNA修飾(エピトランスクリプトーム)の解明
2020 - 2023 Mechanistic insights into spatio-temporal regulation of RNA in cardio-metabolic disease
2020 - 2022 Development of a bacteria-derived ACE2-like enzyme as a therapeutics for treating cardiovascular diseases

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Papers (72)：

Toshiki Yamada, Megumi Tatematsu, Shunsuke Takasuga, Akane Fuchimukai, Kenki Yamagata, Shinsuke Seki, Keiji Kuba, Hideyuki Yoshida, Ichiro Taniuchi, Günter Bernhardt, et al. TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy. The Journal of experimental medicine. 2023. 220. 7
Kohei Kemuriyama, Jianbo An, Satoru Motoyama, Yushi Nagaki, Tomokazu Yamaguchi, Yusuke Sato, Akiyuki Wakita, Yoshihiro Minamiya, Keiji Kuba. Squamous cell carcinoma-derived G-CSF promotes tumor growth and metastasis in mice through neutrophil recruitment and tumor cell proliferation, associated with poor prognosis of the patients. Genes to Cells. 2023. 28. 8. 573-584
Daiki Yamada, Yudai Kojima, Akinori Hosoya, Masahiro Suzuki, Taro Watabe, Tadahiko Inoue, Naoya Tsugawa, Takehito Asakawa, Yuki Yonemoto, Michio Onizawa, et al. Apelin expression is downregulated in T cells in a murine model of chronic colitis. Biochemical and biophysical research communications. 2023. 647. 72-79
Jianbo An, Yushi Nagaki, Satoru Motoyama, Yuta Kuze, Midori Hoshizaki, Kohei Kemuriyama, Tomokazu Yamaguchi, Takashi Ebihara, Yoshihiro Minamiya, Yutaka Suzuki, et al. Identification of Galectin-7 as a crucial metastatic enhancer of squamous cell carcinoma associated with immunosuppression. Oncogene. 2022. 41. 50. 5319-5330
Hiromu Fujita, Satoru Motoyama, Jianbo An, Yushi Nagakai, Tomokazu Yamaguchi, Souichi Koyota, Yusuke Sato, Akiyuki Wakita, Kazuhiro Imai, Keiji Kuba, et al. Peritumoral CD16b positive-neutrophil accumulation strongly correlates with regional lymph node metastasis in thoracic esophageal squamous cell cancer. Surgery. 2022. 171. 6. 1535-1542

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MISC (31)：

内海大知, 浅賀正充, 鎌田春彦, 永田諭志, 仲地ゆたか, 山口智和, 河岡義裕, 久場敬司, 保富康宏. CAG-hACE2 Tgマウスを用いたSARS-CoV-2経気道感染モデルの樹立. 日本薬学会年会要旨集. 2022. 142年会. 28PO2-07S
Utsumi Daichi, Masamitsu Asaka, Haruhiko Kamada, Satoshi Nagata, Yutaka Nakachi, Tomokazu Yamaguchi, Yoshihiro Kawaoka, Keiji Kuba, Yasuhiro Yasutomi. Establishment of SARS-CoV-2 respiratory tract infection model in CAG promoter-driven hACE2 transgenic mice. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022. 95. 2-P
小泉幸央, 長井賢一郎, GAO Lina, 山口智和, 夏井美幸, 今井由美子, 蓮見惠司, 杉山俊博, 久場敬司. 環状ペプチドマルホルミンが賦活化する細胞性血栓溶解にはRSK1の活性化が関与する. 日本農芸化学会大会講演要旨集(Web). 2018. 2018. ROMBUNNO.3A14p01 (WEB ONLY)
Tomokazu Yamaguchi, Takashi Suzuki, Teruki Sato, Miyuki Natsui, Ayumi Kadowaki, Chitose Sato, Yukio Koizumi, Akinori Takahashi, Tadashi Yamamoto, Yumiko Imai, et al. Analysis for the role of CCR4-NOT complex in regulation of adenine nucleotide metabolism in the hearts. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2016. 130. 3. S78-S78
木村洋貴, 江口賢史, 久場敬司, 今井由美子, 高須賀俊輔, 伊藤玲悦, 中村亮太郎, 中西広樹, 石川将己, 佐々木純子, et al. 脂質シグナリングとその破綻がもたらす病態の理解心肥大におけるホスホイノシタイド代謝酵素Vps34のタンパク質分解機構の役割. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [3W6-6]

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Education (2)：

- 2001 九州大学大学院医学研究院
- 1995 Kyushu University School of Medicine

Professional career (1)：

医学博士 (九州大学)

Work history (9)：

2022/10 - 現在 Kyushu University Department of Pharmacology, Graduate School of Medical Sciences Professor
2014/08 - 2022/10 Akita University
2013 - 2017 戦略的創造研究推進事業(さきがけ)「生体恒常性」領域研究員
2008 - 2014 Akita University
2007 - 2008 Tokyo Medical and Dental University Medical Research Institute

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