Research field (3)：
Veterinary medicine
, Respiratory medicine
, Laboratory animal science
Research theme for competitive and other funds (19)：
2022 - 2025 免疫逃避機構を応用した新たな肺移植の戦略
2022 - 2025 Development of pro-inflammatory treatment by cross-sectional control of aging lung metabolism and epigenetics
2019 - 2024 持続肺換気保存法を用いたドナー肺機能改善と長時間肺保存法の開発
2019 - 2023 Why is prognosis of lung transplant recipient from elderly donors poor? –Elucidation of mechanisms and establishment of therapeutic intervention strategy-
2018 - 2023 加齢による呼吸器疾患とリゾホスファチジン酸の関連 -肺の中の混沌と秩序-
2018 - 2022 Ex vivo wet lab training system by veterinarian and surgeon
2018 - 2021 A novel immunosuppresive therapy by Type 1 regulatory T cells after lung transplantation
2018 - 2021 Elucidation of the pathophysiology of pulmonary fibrosis and development of new treatments by applying metabolome analysis
2015 - 2018 Production of human induced bronchiolar progenitors
2015 - 2018 A new therapeutic strategy for multiple myeloma by targeting senescence of bone marrow microenvironment
2015 - 2018 Differantial Mechanism of Lung Cells induced by Mesenchymal Stem Cells and the Treatment of Intractable Respiratory Diseases
2012 - 2015 New Therapy for Intractable Pulmonary Fibrosis using Humoral Factors released from Mesenchymal Stem Cells
2011 - 2012 Clarification of physiological function of lysophosphatidic acid in maintenance of lung stem cells and application for respiratory diseases.
2009 - 2010 Establishment of new strategy for targeting lung cancer stem cells by using bone marrow-derived mesenchymal stem cells
2007 - 2008 Decrease of type II pneumocyte function by aging in the process oflung fibrosis : multi-aspect evaluation of STAM1 gene
2006 - 2007 肺幹細胞の効率的分離法の開発と肺幹細胞の解析
2005 - 2006 HGF導入骨髄由来間葉系幹細胞を用いた肺組織障害に対する新規治療法の開発
2005 - 2006 Activation mutations in EGF receptor kinase have the advantages of cell physiology in the bronchiolar region : Implication of anti-apoptotic signals and lung tumorigenesis and metastasis.
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Papers (35)：
Shinya Ohkouchi, Masahiko Kanehira, Daisuke Saigusa, Manabu Ono, Ryushi Tazawa, Hideya Terunuma, Taizou Hirano, Tadahisa Numakura, Hirotsugu Notsuda, Chihiro Inoue, et al. Metabolic and Epigenetic Regulation of SMAD7 by Stanniocalcin-1 (STC1) Ameliorates Lung Fibrosis. American journal of respiratory cell and molecular biology. 2022. 67. 3. 320-333
Yamato Suzuki, Hisashi Oishi, Masahiko Kanehira, Yasushi Matsuda, Takashi Hirama, Masafumi Noda, Yoshinori Okada. Effect of CTLA4-Ig on Obliterative Bronchiolitis in a Mouse Intrapulmonary Tracheal Transplantation Model. Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia. 2021. 27. 6. 355-365
Kotaro Abe, Masahiko Kanehira, Shinya Ohkouchi, Sakiko Kumata, Yamato Suzuki, Hisashi Oishi, Masafumi Noda, Akira Sakurada, Eisaku Miyauchi, Tohru Fujiwara, et al. Targeting stanniocalcin-1-expressing tumor cells elicits efficient antitumor effects in a mouse model of human lung cancer. Cancer Medicine. 2021. 10. 9. 3085-3100
Shinya Ohkouchi, Masahiko Kanehira, Yoshinori Okada, Hajime Kurosawa. NEW INSIGHTS OF THE PATHOLOGY OF PULMONARY FIBROSIS REVEALED BY METABOLOME ANALYSIS similar to ANTI-FIBROTIC FACTOR STANNIOCALCIN1 (STC1) AND SYSTEMIC DAMAGE RESPONSE similar to. RESPIROLOGY. 2018. 23. 64-64
