Research keywords (5)：
Protein folding
, Enzyme model
, Neurodegenerative diseases
, Peptide synthesis
, Flow chemistry
Research theme for competitive and other funds (2)：
2017 - 2020 Development and pharmacological investigation of novel diselenide compounds as a medicine for folding diseases
2014 - 2016 Development of an effective folding procedure for SS-containing proteins by using a micro flow chemistry
Papers (44)：
Kenta Arai, Masaki Okumura, Young-Ho Lee, Hidekazu Katayama, Kenji Mizutani, Yuxi Lin, Sam-Yong Park, Kaichiro Sawada, Masao Toyoda, Hironobu Hojo, et al. Diselenide-bond replacement of the external disulfide bond of insulin increases its oligomerization leading to sustained activity. Communications Chemistry. 2023. 6. 1
Yuya Nishizawa, Yuri Satoh, Osamu Kanie, Kenta Arai. Resin-supported cyclic telluride as a heterogeneous promoter of disulfide formation under solid-liquid biphasic conditions. New Journal of Chemistry. 2023. 47. 40. 18537-18546
Shunsuke Okada, Yosuke Matsumoto, Rikana Takahashi, Kenta Arai, Shingo Kanemura, Masaki Okumura, Takahiro Muraoka. Semi-enzymatic acceleration of oxidative protein folding by N-methylated heteroaromatic thiols. Chemical Science. 2023. 14. 28. 7630-7636
Kenta Arai. Small Organoselenium Catalysts as a Potential Manipulator for Redox Homeostasis and Proteostasis. Chalcogen Chemistry: Fundamentals and Applications. 2023. 648-665
Kenta Arai, Haruka Toba, Nozomi Yamamoto, Mao Ito, Rumi Mikami. Modeling Type-1 Iodothyronine Deiodinase with Peptide-Based Aliphatic Diselenides: Potential Role of Highly Conserved His and Cys Residues as a General Acid Catalyst. Chemistry - A European Journal. 2023. 29. 3
Masaki Okumura, Tsubura Kuramochi, Yuxi Lin, Ran Furukawa, Kenji Mizutani, Takeshi Yokoyama, Mingeun Kim, Mi Hee Lim, Hyon-Seung Yi, Kenta Arai, et al. Dose-response relationship for the resistance of human insulin to degradation by insulin-degrading enzyme. BioRxiv. 2023
