Rchr
J-GLOBAL ID：201901018264109649
Update date: Nov. 26, 2024
Arai Kenta
アライ ケンタ | Arai Kenta
Affiliation and department：
Other affiliations (1)：
Research field (1)：
Bioorganic chemistry
Research keywords (5)：
Protein folding
, Enzyme model
, Neurodegenerative diseases
, Peptide synthesis
, Flow chemistry
Research theme for competitive and other funds (2)：
- 2017 - 2020 Development and pharmacological investigation of novel diselenide compounds as a medicine for folding diseases
- 2014 - 2016 Development of an effective folding procedure for SS-containing proteins by using a micro flow chemistry
Papers (47)：
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Rumi Mikami, Yuya Nishizawa, Yuki Iwata, Shingo Kanemura, Masaki Okumura, Kenta Arai. ER Oxidoreductin 1-Like Activity of Cyclic Diselenides Drives Protein Disulfide Isomerase in an Electron Relay System. ChemBioChem. 2024
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Yuri Satoh, Yosuke Ono, Rikana Takahashi, Hidekazu Katayama, Michio Iwaoka, Osamu Yoshino, Kenta Arai. Seleno-relaxin analogues: effect of internal and external diselenide bonds on the foldability and a fibrosis-related factor of endometriotic stromal cells. RSC chemical biology. 2024. 5. 8. 729-737
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Tsubura Kuramochi, Yukino Yamashita, Kenta Arai, Shingo Kanemura, Takahiro Muraoka, Masaki Okumura. Boosting the enzymatic activity of CxxC motif-containing PDI family members. Chemical communications (Cambridge, England). 2024. 60. 48. 6134-6137
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Kenta Arai, Masaki Okumura, Young-Ho Lee, Hidekazu Katayama, Kenji Mizutani, Yuxi Lin, Sam-Yong Park, Kaichiro Sawada, Masao Toyoda, Hironobu Hojo, et al. Diselenide-bond replacement of the external disulfide bond of insulin increases its oligomerization leading to sustained activity. Communications Chemistry. 2023. 6. 1
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Yuya Nishizawa, Yuri Satoh, Osamu Kanie, Kenta Arai. Resin-supported cyclic telluride as a heterogeneous promoter of disulfide formation under solid-liquid biphasic conditions. New Journal of Chemistry. 2023. 47. 40. 18537-18546
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MISC (11)：
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Young-Ho Lee, Tomohide Saio, Mai Watabe, Motonori Matsusaki, Shingo Kanemura, Yuxi Lin, Taro Mannen, Tsubura Kuramochi, Katsuya Iuchi, Michiko Tajiri, et al. Ca2+-driven PDIA6 phase separation to ensure proinsulin quality control. 2024
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Masaki Okumura, Tsubura Kuramochi, Yuxi Lin, Ran Furukawa, Kenji Mizutani, Takeshi Yokoyama, Mingeun Kim, Mi Hee Lim, Hyon-Seung Yi, Kenta Arai, et al. Dose-response relationship for the resistance of human insulin to degradation by insulin-degrading enzyme. BioRxiv. 2023
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荒井 堅太, 岩岡 道夫. インスリンの高次構造形成過程の解明 インスリン製剤の簡便な化学合成への展開. ファルマシア. 2018. 54. 12. 1135-1139
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荒井堅太, 岩岡道夫. インスリンの簡便な化学合成法の開発 : 未来の糖尿病治療への期待. 化学. 2018. 73. 10. 29-33
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荒井堅太. セレン原子が切り開く、インスリン化学合成と機能の向上を目指した新しい道筋. アカデミストジャーナル. 2017
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Patents (3)：
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樹脂担持環状テルル化合物
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環状ジセレニド化合物、タンパク質フォールディング剤、及びタンパク質のフォールディング方法
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リラキシンの製造方法
Books (3)：
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Chalcogen Chemistry: Fundamentals and Applications
The Royal Society of Chemistry 2023
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Functional Disulfide Bonds
Springer 2019
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Organoselenium Compounds in Biology and Medicine: Synthesis, Biological and Therapeutic Treatments
The Royal Society of Chemistry 2017
Lectures and oral presentations (17)：
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Bio-redox regulation by small molecular diselenide and selenenyl sulfide compounds
(11th Workshop of SeS Redox and Catalysis 2024)
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Structural Control of Proteins by Utilizing Selenium Chemistry
(Lecture in University of Melbourne 2024)
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典型元素戦略が拓く生命機能の拡張と強化の可能性
(東海大学 次世代研究創成拠点シンポジウム2023 2023)
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Allosteric selenopeptides as a model of selenoenzymes
(The 9th International Selenium Conference, focused on Selenium in Chemistry, Biology and Medicine (Se2023) 2023)
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Aliphatic Diselenides as a Potential Manipulator for Proteostasis
(15th International Conference on the Chemistry of Selenium and Tellurium (ICCST-15) 2022)
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Education (1)：
- 2010 - 2012 Tokai University Graduate School of Science and Technology
Work history (6)：
Awards (2)：
- 2020/03 - TU Science Award 2020
- 2016/05 - SeS redox & catalysis Bentham Current Green Chemistry Award for an excellent poster presentation
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