Moriwaki Kazumasa

Affiliation and department：
Job title： Associate Professor/Lecturer

Research field (2)： Tumor biology , Pathobiochemistry

Research keywords (7)： Patient-derived cancer models , 癌転移 , 細胞接着 , 細胞運動 , 糖鎖 , 癌治療 , 希少がん

Research theme for competitive and other funds (7)：

2021 - 2024 O-GlcNAc修飾による癌微小環境制御機能の解析
2019 - 2022 Development of novel diagnosis and therapy in cancer targetting reversible system of intracellular glycosylation
2020 - 2021 患者由来腫瘍培養系を用いた耳下腺癌の治療薬物スクリーニングの基盤構築
2017 - 2020 Role of TME O-GlcNAcylation in cancer proliferation
2016 - 2019 Effect of elevated O-GlcNAc modification on onset of gastric and colon cancer

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Papers (23)：

Shigeaki Muto, Kazumasa Moriwaki, Daisuke Nagata, Mikio Furuse. Axial heterogeneity of superficial proximal tubule paracellular transport in mice. American journal of physiology. Renal physiology. 2024
Makoto Shirakawa, Shunichi Yokoe, Takatoshi Nakagawa, Kazumasa Moriwaki, Toshihisa Takeuchi, Michio Asahi. Rapamycin and Starvation Mitigate Indomethacin-Induced Intestinal Damage through Preservation of Lysosomal Vacuolar ATPase Integrity. The Journal of pharmacology and experimental therapeutics. 2024. 390. 1. 108-115
Kazumasa Moriwaki, Yusuke Ayani, Hiroko Kuwabara, Tetsuya Terada, Masaaki Higashino, Ryo Kawata. Differential expression of TRKB tyrosine kinase in the two histological types of parotid salivary duct carcinoma with cancer aggressiveness. Oral Oncology. 2024. 151. 106751
Natsuko MORITA, Hirofumi MORIHARA, Kazumasa MORIWAKI, Atsushi DAIMON, Michio ASAHI, Masahide OHMICHI. Intravenous Injection of iPS Cell-Derived Endothelial Progenitor Cells Prevents Miscarriage by Releasing Pro-Angiogenic Factors in a Mouse Model of Recurrent Spontaneous Abortion. Bulletin of Osaka Medical and Pharmaceutical University. 2023. 69. 1,2. 21-30
Mahito Matsuno, Shunichi Yokoe, Takehiro Nagatsuka, Hirofumi Morihara, Kazumasa Moriwaki, Michio Asahi. O-GlcNAcylation-induced GSK-3β activation deteriorates pressure overload-induced heart failure via lack of compensatory cardiac hypertrophy in mice. Frontiers in Endocrinology. 2023. 14

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MISC (29)：

上田康裕, 森脇一将, 小嶋融一, 竹内利寿, 朝日通雄, 樋口和秀. Elevated O-GlcNAcylation stabilizes FOXM1 protein via suppression of its proteasomal degradation. 日本消化管学会雑誌. 2021. 5. Suppl. 169-169
森脇一将, 上田康裕, 樋口和秀, 朝日通雄. O -GlcNAc修飾上昇はFBXL2によるFOXM1のポリユビキチン化を抑制してFOXM1を増加させる(Elevated O-GlcNAcylation increases FOXM1 via suppression of FBXL2-mediated its poly-ubiquitination). 日本癌学会総会記事. 2019. 78回. E-1026
Yasuhiro Ueda, Kazumasa Moriwaki, Noriaki Sugawara, Masanobu Fukumoto, Satoshi Harada, Kazuhiro Ota, Yuichi Kojima, Toshihisa Takeuchi, Kazuhide Higuchi, Michio Asahi. ELEVATED O-GLCNACYLATION INCREASES FOXM1 PROTEIN VIA SUPPRESSION OF ITS POLY-UBIQUITINATION AND SUBSEQUENT PROTEASOMAL DEGRADATION. GASTROENTEROLOGY. 2019. 156. 6. S1091-S1091
森脇一将, 上田康裕, 樋口和秀, 朝日通雄. O-GlcNAc修飾の上昇はFOXM1タンパクのプロテアソームでの分解を抑制してその発現を安定化している(Elevated O-GlcNAcylation stabilizes FOXM1 protein via suppression of its proteasomal degradation). 日本癌学会総会記事. 2018. 77回. 2124-2124
綾仁悠介, 森脇一将, 桑原宏子, 寺田哲也, 河田了, 朝日通雄. BDNF/TRKBシグナルは低分化型口腔扁平上皮癌治療の標的候補である(Therapeutic potential of targeting BDNF/TRKB signaling in poorly differentiated oral squamous cell carcinomas). 日本癌学会総会記事. 2018. 77回. 535-535

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Books (3)：

分子細胞治療リンパ管の発生分化とその病態
先端医学社 2008
生命の科学タンパク質間相互作用
医学書院 2007
分子生物学・免疫学キーワード辞典第2版
2003

Lectures and oral presentations (59)：

Intercellular crosstalk between patient-derived parotid gland cancer cells and CAFs via the BDNF/TRKB pathway
(日本患者由来がんモデル学会・日本ヒト細胞学会合同学術集会2024 2024)
Elevated O-GlcNAcylation in TME enhances metastasis of PAN02 pancreatic adenocarcinoma
(2023)
The BDNF/TRKB pathway promotes EMT to induce parotid gland cancer cell aggressiveness via interaction with CAF
(2022)
The BDNF/TRKB pathway promotes EMT to enhance parotid gland cancer cell aggressiveness via cross-talk with CAFs
(2022)
BDNF/TRKB axis provokes EMT progression to induce cell aggressiveness via cross-talk with cancer associated fibroblasts in human parotid gland cancer
(2022)

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Professional career (2)：

Doctor of Philosophy (Kyoto University)
Master (Osaka University)

Work history (2)：

2012 - 現在 Osaka Medical and Pharmaceutical University Department of Pharmacology, Faculty of Medicine
2007 - 2012 Kobe University Graduate School of Medicine

Committee career (2)：

2023/01 - 現在日本薬理学会薬理学エデュケーター
2022/04 - 現在日本薬理学会学術評議員

Awards (2)：

2022/11 - Poster Award
2013/05 - 第60回日本生化学会近畿支部例会優秀発表賞腸管上皮細胞のバリア機能を調節する機能阻害抗体の作製

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