Yasuda Tadahito

ヤスダタダヒト | Yasuda Tadahito

Affiliation and department：

Research field (1)： Tumor biology

Research keywords (3)：腫瘍微小環境 , 細胞老化 , 胃癌

Research theme for competitive and other funds (4)：

2023 - 2026 遠隔臓器コミュニケーションによるスキルス胃癌線維化メカニズムの解明
2022 - 2025 がんーストローマ代謝物クロストークによる膵癌進展メカニズムの解明
2021 - 2024 Elucidation of diversity and therapeutic target in scirrhous gastric cancer stroma
2020 - 2023 Identification of molecular mechanism underlying peritoneal metastasis progression by tumor stromal cells

Papers (24)：

Jun Zhang, Lingfeng Fu, Huaitao Wang, Atsuko Yonemura, Takashi Semba, Noriko Yasuda-Yoshihara, Akiho Nishimura, Takuya Tajiri, Yilin Tong, Tadahito Yasuda, et al. RAC1-mediated Integrin alpha-6 expression in E-cadherin-deficient gastric cancer cells promotes interactions with the stroma and peritoneal dissemination. Cancer letters. 2024. 216901-216901
Tadahito Yasuda, Y Alan Wang. Gastric cancer immunosuppressive microenvironment heterogeneity: implications for therapy development. Trends in cancer. 2024
Atsuko Yonemura, Takashi Semba, Jun Zhang, Yibo Fan, Noriko Yasuda-Yoshihara, Huaitao Wang, Tomoyuki Uchihara, Tadahito Yasuda, Akiho Nishimura, Lingfeng Fu, et al. Mesothelial cells with mesenchymal features enhance peritoneal dissemination by forming a protumorigenic microenvironment. Cell reports. 2024. 43. 1. 113613-113613
Fumimasa Kitamura, Takashi Semba, Noriko Yasuda-Yoshihara, Kosuke Yamada, Akiho Nishimura, Juntaro Yamasaki, Osamu Nagano, Tadahito Yasuda, Atsuko Yonemura, Yilin Tong, et al. Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer. JCI insight. 2023. 8. 20
Xichen Hu, Tadahito Yasuda, Noriko Yasuda-Yosihara, Atsuko Yonemura, Terumasa Umemoto, Yutaka Nakachi, Kohei Yamashita, Takashi Semba, Kota Arima, Tomoyuki Uchihara, et al. Downregulation of 15-PGDH enhances MASH-HCC development via fatty acid-induced T-cell exhaustion. JHEP Reports. 2023. 5. 12. 100892-100892

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MISC (14)：

ヤスダタダヒト, ババヒデオ, イシモトタカツグ. 消化管幹細胞の寛容性とニッチによるホメオスタシスの維持. 2021. 72. 2. 109-112
北村文優, 石本崇胤, 秋山貴彦, 上村紀雄, 安田忠仁, 米村敦子, 伊東山瑠美, 内原智幸, 東孝暁, 今井克憲, et al. 膵癌腹膜播種に関与する異常タンパクの同定(Identification of aberrant proteins involved in peritoneal dissemination of pancreatic cancer). 日本癌学会総会記事. 2019. 78回. P-1326
内原智幸, 米村敦子, 三宅慧輔, 安田忠仁, 秋山貴彦, 北村文優, 伊東山瑠美, 岩槻政晃, 岩上志朗, 吉田直矢, et al. 胃癌Cancer associated fibroblastsによる薬剤抵抗性獲得メカニズムの解明(To identify the molecular mechanisms of drug resistance induced by gastric cancer associated fibroblasts). 日本癌学会総会記事. 2019. 78回. E-3101
安田忠仁, 小岩麻由, 三宅慧輔, 米村敦子, 内原智幸, 伊東山瑠美, ブ・ルコ, フ・リンフェン, 江藤弘二郎, 岩槻政晃, et al. 胃癌CAFsのヒストン修飾を介したSASPの維持と腹膜播種の進展(Gastric cancer CAFs maintain SASP through epigenetic histone modification and enhance peritoneal metastasis). 日本癌学会総会記事. 2019. 78回. P-3239
Takatsugu Ishimoto, Kota Arima, Tomoyuki Uchihara, Keisuke Miyake, Atsuko Yonemura, Tadahito Yasuda, Rumi Itoyama, Masaaki Iwatsuki, Yoshifumi Baba, Naoya Yoshida, et al. Inhibition of 15-PGDH causes Kras-driven tumor expansion through prostaglandin E2-ALDH1 signaling in the pancreas. CANCER RESEARCH. 2019. 79. 13

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Books (1)：

生体の科学
医学書院 2021

Education (2)：

2016 - 2020 Kumamoto University Faculty of Life Sciences Division of Advanced Biomedical Sciences
2010 - 2016 Kumamoto University School of Medicine School of Medicine

Professional career (1)：

M.D., Ph.D. (Kumamoto University)

Work history (2)：

2023/02 - 現在 Indiana University School of Medicine Postdoctoral Fellow
2021/04 - 2023/01 Kumamoto University

Awards (8)：

2023 - British Journal of Cancer Emerging Leaders in the oncology field
2022 - Cell Press Best of Cell Reports 2021
2022 - 武田科学振興財団海外研究留学助成
2021 - 日本癌学会 JCA若手研究者ポスター賞
2021 - JDDW 若手奨励賞

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Association Membership(s) (4)：

日本生化学会 , 日本分子生物学会 , 日本癌学会 , 日本外科学会

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