Shimizu Kosuke

Affiliation and department：
Job title： Associate Professor

Research field (3)： Biomaterials , Pharmaceuticals - analytical and physicochemistry , Pharmaceuticals - analytical and physicochemistry

Research keywords (6)： Optical imaging , Autoimmune disease , Cancer , Molecular Imaging , Targeting , Drug Delivery System

Research theme for competitive and other funds (5)：

2010 - 2011 Development of novel nanoparticles for DDS, and establishment of Therapeutic modality for brain ischemia by use of these nanoparticles.
2008 - 2010 Influence of tumor lymphangiogenesis on tumor-targeting liposomal DDS
2008 - 2010 A novel targeting DDS for the treatment of autoimmune diseases and allergy
2008 - 2009 難治がんの克服を目標した発展型腫瘍新生血管標的化DDSに関する研究
2006 - 2007 Development of Radical Treatment Modality for Curing Allergies and Immune Diseases by a Novel Consept, RTDDS

Papers (74)：

Satoshi Ota, Hiroki Kosaka, Keita Honda, Kota Hoshino, Haruki Goto, Masato Futagawa, Yasushi Takemura, Kosuke Shimizu. Characterization of microscopic structures in living tumor by in vivo measurement of magnetic relaxation time distribution of intratumor magnetic nanoparticles. Advanced Materials. 2024. e2404766
Hideya Kawasaki, Takahiko Hariyama, Isao Kosugi, Shiori Meguro, Futoshi Iwata, Kosuke Shimizu, Yasuhiro Magata, Toshihide Iwashita. Human-induced pluripotent stem cells are resistant to human cytomegalovirus infection primarily at the attachment level due to the reduced expression of cell-surface heparan sulfate. Journal of Virology. 2024
Yuki Kimura, Tomohiro Ohkubo, Kosuke Shimizu, Yasuhiro Magata, Enoch Y Park, Masakazu Hara. Inhibition of cryoaggregation of phospholipid liposomes by an Arabidopsis intrinsically disordered dehydrin and its K-segment. Colloids and surfaces. B, Biointerfaces. 2022. 211. 112286-112286
Kosuke Shimizu, Kazuki Agata, Shohei Takasugi, Shungo Goto, Yudai Narita, Tomohiro Asai, Yasuhiro Magata, Naoto Oku. New strategy for MS treatment with autoantigen-modified liposomes and their therapeutic effect. Journal of controlled release : official journal of the Controlled Release Society. 2021. 335. 389-397
清水広介, 高杉昇平, 阿形寿規, 成田雄大, 浅井知浩, 奥直人, 間賀田泰寛. 多発性硬化症治療に向けた自己抗原修飾リポソーム製剤の開発. 神経免疫学. 2020. 25. 1. 101-101

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MISC (31)：

Kosuke Shimizu. New targeting DDS for the treatment of immune disease. PHARM TECH JAPAN. 2021. 37. 13. 161-168
Kosuke Shimizu. Treatment of multiple sclerosis with DDS drug targeting to autoantigen-recognizing immune cells. Drug Delivery System. 2020. 35. 5. 367-375
Kosuke Shimizu. Recent advances in the treatment of MS with DDS drugs. BioClinica autoimmune diseases. 2020. 9. 1. 137-141
清水広介, 奥直人. Advantages of antibody usage in liposomal DDS for cancer chemotherapy. Drug Delivery System. 2019. 34. 1. 22-28
森智哉, 大塚和摩, 竹内祥人, 成田雄大, 清水広介, 松村保広, 奥直人. Tissue factor標的化リポソームを用いたがんマルチターゲティング. 日本薬学会年会要旨集. 2018. 138年会. 4. 74-74

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Books (7)：

Cancer Drug Delivery Systems Based on the Tumor Microenvironment
Springer 2019 ISBN:9784431568780
Cha No Kinou
2013 ISBN:9784540131004
Polymeric Biomaterials: Medicinal and Pharmaceutical Applications
CRC Press 2013 ISBN:9781420094701
Tumors of the Central Nervous System
Springer 2011 ISBN:9789400713987
Drug delivery using functional DDS carriers
CMC Publishing 2008 ISBN:9784781300528

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Professional career (1)：

Work history (1)：

2024/04 - 現在 Hamamatsu University School of Medicine Nanotheranostics Laboratory, Division of Innovative Diagnostic and Therapeutic Research, Institute of Photonics Medicine Associate Professor

Awards (8)：

2023/09 - 日本神経免疫学会 2023年度日本神経免疫学会研究創世賞標的化DDSが拓く新たな多発性硬化症治療創薬
2022/05 - 日本薬剤学会 2022年度日本薬剤学会旭化成創剤研究奨励賞免疫疾患治療根治に向けた標的化DDS創薬研究
2019/09 - Japan Society for Neuroimmunology Best Poster Award
2016 - Japan Society of Drug Delivery System 8th Japan Society of Drug Delivery System Award for Young Scientists 2016
2015 - The Pharmaceutical Society of Japan The Pharmaceutical Society of Japan Tokai Branch Award for Young Scientists 2015

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