Ohgane Kenji

オオガネケンジ | Ohgane Kenji

Affiliation and department：
Homepage URL (1)： https://www-p.sci.ocha.ac.jp/ohganelab/

Research field (7)： Bioorganic chemistry , Structural/physical organic chemistry , Molecular biochemistry , Cell biology , Chemical biology , Pharmaceuticals - chemistry and drug development , Pharmaceuticals - chemistry and drug development

Research theme for competitive and other funds (9)：

2023 - 2027 New molecular shapes from strained aromatic foldamer macrocycles and their application to development of PPI inhibitors
2023 - 2026 内在性脂質に基づく新規自然免疫調節剤の創製と作用機序の解析
2023 - 2025 Sanfilippo症候群C型を標的とした薬理学的シャペロン探索
2023 - 2024 ムコ多糖症に対するシャペロン薬探索基盤の構築
2020 - 2023 Development of novel cholesterol synthesis modulators that alter stability of cholesterol-biosynthetic enzymes

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Papers (32)：

Kota Noritsugu, Takehiro Suzuki, Kosuke Dodo, Kenji Ohgane, Yasue Ichikawa, Kota Koike, Satoshi Morita, Takashi Umehara, Kenji Ogawa, Mikiko Sodeoka, et al. Lysine long-chain fatty acylation regulates the TEAD transcription factor. Cell reports. 2023. 42. 4. 112388-112388
Hirofumi Ohashi, Kazane Nishioka, Tomoki Kurihara, Kou Nakamura, Masako Yamasaki, Yuuka Ibayashi, Kanta Fuchiyama, Shogo Kamo, Yuuki Furuyama, Kenji Ohgane, et al. Anti-hepatitis C Virus Activity of Juglorubin Derivatives. Chemical & pharmaceutical bulletin. 2023. 71. 11. 843-845
Kota Kawamura, Hiromasa Yoshioka, Chikako Sato, Tomoko Yajima, Yuuki Furuyama, Kouji Kuramochi, Kenji Ohgane. Fine-tuning of nitrogen-containing bisphosphonate esters that potently induce degradation of HMG-CoA reductase. Bioorganic & Medicinal Chemistry. 2022. 78. 117145-117145
Ryuki Asakawa, Kanta Fuchiyama, Yunosuke Ishii, Keisuke Hosaka, Atsushi Kobayashi, Kei Shimazaki, Junki Nagasawa, Sayaka Tsuchida, Kazunari Ushida, Makoto Matsubayashi, et al. Synthesis and cytotoxic activities of 8-and 6-demethyleucalyptins. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY. 2022. 86. 9. 1200-1206
Keigo Hirai, Hiroko Yamashita, Shusuke Tomoshige, Yugo Mishima, Tatsuya Niwa, Kenji Ohgane, Mayumi Ishii, Kayoko Kanamitsu, Yui Ikemi, Shinsaku Nakagawa, et al. Conversion of a PROTAC Mutant Huntingtin Degrader into Small-Molecule Hydrophobic Tags Focusing on Drug-like Properties. ACS Medicinal Chemistry Letters. 2022. 13. 3. 396-402

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MISC (10)：

Maho Saita, Kyoko Aikawa, Kenji Ohgane. Microplate-based DNA Quantification with EzFluoroStain DNA reagent v1. protocols.io. 2021
大金賢司, 吉岡広大. コレステロール生合成の新たな制御ポイント-スクアレンモノオキシゲナーゼの基質によるアロステリックな安定化-. 生化学. 2021. 93. 147-151
吉岡広大, COATES Hudson W., CHUA Ngee Kiat, 橋本祐一, BROWN Andrew J., 大金賢司, 大金賢司. Squalene as a novel feedforward regulator of squalene monooxygenase stability. 日本薬学会年会要旨集(CD-ROM). 2020. 140th (Web)
豊田洋介, 吉岡広大, 鷺森郁也, 橋本祐一, 大金賢司. Design, synthesis, and evaluation of photo-crosslinking HMG-CoA reductase degrader, SR12813. 日本薬学会年会要旨集(CD-ROM). 2020. 140th (Web)
大金賢司. タキソール誘導体の新たな有用性:ほ乳類細胞における半数体細胞の維持. ファルマシア. 2020. 56. 4. 345-345

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Patents (4)：

Books (2)：

生体分子と疾患 : ヘルスサイエンスの切り札としての化学
化学同人 2021 ISBN:9784759813999
膜タンパク質工学ハンドブック (監修: 津本浩平、浜窪隆雄)
(株)エヌ・ティー・エス 2020 ISBN:9784860435370

Lectures and oral presentations (63)：

イトラコナゾールによる糖鎖プロセシング阻害作用の解明を目指した、構造活性相関およびプローブ化研究
(日本薬学会第144年会 2024)
STING経路の活性化を抑制するオキシステロール誘導体の構造活性相関
(日本薬学会第144年会 2024)
リソソームタンパク質を標的とした薬理学的シャペロンの探索
(日本薬学会第144年会 2024)
UBRタンパク質リガンドを活用した新規PROTACの開発
(日本薬学会第144年年会 2024)
Azamonardine形成反応を利用した新規HGSNAT活性評価法の開発
(日本薬学会第144年会 2024)

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Works (3)：

Simultaneous fitting of sigmoid curves in Excel (Excel Solver Add-in) / protocols.io
Kenji Ohgane 2019 -
Sigmoid fitting in Excel (Excel Solver Add-In) / protocols.io
Kenji Ohgane 2019 -
Quantification of Gel Bands by an Image J Macro, Band/Peak Quantification Tool / protocols.io
Kenji Ohgane, Hiromasa Yoshioka 2019 -

Education (3)：

2008 - 2013 The University of Tokyo Graduate School of Pharmaceutical Sciences
2004 - 2008 The University of Tokyo Faculty of Pharmaceutical Sciences
2001 - 2004 Sagamihara Senior High School

Professional career (1)：

Ph.D. (The University of Tokyo)

Work history (9)：

2021/04 - 現在 Ochanomizu University Department of Chemistry Assistant Professor (full-time Lecturer)
2020/04 - 2021/03 Tokyo University of Science Department of Applied Biological Science, Faculty of Science and Technology Assistant Professor
2017/10 - 2021/03 Ochanomizu University Department of Chemistry Part-time Lecturer
2018/04 - 2020/03 Institute for Quantitative Biosciences, the University of Tokyo Laboratory of Bioorganic Chemistry Assistant Professor
2017/02 - 2018/03 Institute for Molecular and Cellular Biosciences, the University of Tokyo Laboratory of Bioorganic Chemistry Assistant Professor

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