Imai Yu

イマイユウ | Imai Yu

Affiliation and department：

Research field (1)： Applied microbiology

Papers (10)：

Keiichiro Mukai, Tomoko Shibayama, Yu Imai, Takeshi Hosaka. Phenomenological interpretations of the mechanism for the concentration-dependent positive effect of antibiotic lincomycin on Streptomyces coelicolor A3(2). Applied and Environmental Microbiology. 2023
Yu Imai*, Glenn Hauk*, Jeffrey Quigley, Libang Liang, Sangkeun Son, Meghan Ghiglieri, Michael F. Gates, Madeleine Morrissette, Negar Shahsavari, Samantha Niles, et al. Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis. Nature Chemical Biology. 2022. 18. 11. 1236-1244
Negar Shahsavari, Boyuan Wang, Yu Imai, Miho Mori, Sangkeun Son, Libang Liang, Nils Böhringer, Sylvie Manuse, Michael F. Gates, Madeleine Morrissette, et al. A Silent Operon of Photorhabdus luminescens Encodes a Prodrug Mimic of GTP. mBio. 2022. 13. 3
Nadja Leimer*, Xiaoqian Wu*, Yu Imai*, Madeleine Morrissette, Norman Pitt, Quentin Favre-Godal, Akira Iinishi, Samta Jain, Mariaelena Caboni, Inga V. Leus, et al. A selective antibiotic for Lyme disease. Cell. 2021. 184. 21. 5405-5418.e16
Hundeep Kaur, Roman P. Jakob, Jan K. Marzinek, Robert Green, Yu Imai, Jani Reddy Bolla, Elia Agustoni, Carol V. Robinson, Peter J. Bond, Kim Lewis, et al. The antibiotic darobactin mimics a β-strand to inhibit outer membrane insertase. Nature. 2021. 593. 7857. 125-129

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MISC (5)：

今井優. 線虫共生細菌培養物から見いだされた結核菌に選択的な抗生物質. バイオサイエンスとインダストリー. 2024. 82. 1. 12-15
今井優. 線虫共生細菌を利用した有用抗生物質探索研究. 未培養微生物研究の最新動向 (第 I 編未培養微生物の探索: 分担) シーエムシー出版. 2023. 16-24
今井優. グラム陰性病原菌を選択的に殺す抗生物質ダロバクチンの発見. 実験医学 2020年4月号カレントトピックス. 2020. 38. 6. 1004-1007
保坂毅, 今井優. 放線菌における抗生物質のホルミシス効果の解析と応用. バイオサイエンスとインダストリー. 2016. 74. 6. 516-518
Development of the Potential of Actinomycetes to Produce Secondary Metabolites and Discovery of New Antibiotics by Modulating the RNA Polymerase and/or Ribosome. 2012. 48. 1. 9-15

Patents (1)：

Lectures and oral presentations (44)：

線虫共生細菌 Photorhabdus khanii から発見された緑膿菌に選択的な活性を示す抗生物質 ADC58
(第 75 回日本生物工学会大会 2023)
Discovery of darobactin, which selectively kills Gram-negative pathogen, by differential screening
(2023)
有用抗生物質探索源としての線虫マイクロバイオームの利用
(創立 100 周年記念第 74 回日本生物工学会大会生物工学が拓く未培養微生物 (微生物ダークマター) の未来 2022)
Mycobacterium tuberculosis を選択的に殺す DNA ジャイレース阻害剤の発見
(日本農芸化学会 2022 年度大会 2022)
3’-amino 3’-deoxyguanosine is a natural nucleoside prodrug antibiotic that selectively kills Escherichia coli
(2021 Boston Bacterial Meeting 2021)

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Education (3)：

2011 - 2015 Shinshu University Interdisciplinary Graduate School of Science and Technology
2009 - 2011 Shinshu University Graduate School, Division of Agriculture
2005 - 2009 Shinshu University Faculty of Agriculture

Work history (3)：

2022/04 - 現在信州大学先鋭領域融合研究群バイオメディカル研究所助教 (特定雇用)
2022/01 - 2022/03 Northeastern University Antimicrobial Discovery Center Associate Research Scientist
2015/11 - 2022/01 Northeastern University Antimicrobial Discovery Center Postdoctoral Research Associate

Awards (2)：

2022/04 - 日本農芸化学会 2022 年度大会トピックス賞
2019/05 - American Society for Microbiology ASM microbe 2019 Outstanding Abstract Award

Association Membership(s) (3)：

日本生物工学会 , JAPAN SOCIETY FOR BIOSCIENCE , American Society for Microbiology

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