Nakamura Takanori

ナカムラタカノリ | Nakamura Takanori

Affiliation and department：
Job title： Senior Assistant Professor

Research field (8)： Medical biochemistry , Fetal medicine/Pediatrics , Mathematical analysis , Chemical biology , Pathobiochemistry , Tumor biology , Cell biology , Molecular biology

Research keywords (22)： Signal transduction , MAPK , ERK , JNK , p38 , mTOR , BCR-ABL , post-translational modification , Phosphorylation , Oxidative stress , Mathematical analysis , Cell death , Cell cycle , Centrosome , Chromosomal instability , Tumorigenesis , 個体形成 , Growth failure , Stress granules , neurodegenerative disease , Liquid-Liquid phase separation , Proximity dependent biotinylation

Research theme for competitive and other funds (16)：

2024 - 2027 初期発生制御分子群の相互作用マップの創出~発育不全病態の包括的理解~
2024 - 2026 がん特有の多極分裂回避機構を標的とする抗がん剤の創出
2023 - 2024 疾患発症機構の解明と新たな創薬標的の創出
2021 - 2024 中心体複製の開始機構と個体発生におけるその破綻
2019 - 2022 「中心体複製開始の制御機構」と癌診断/治療におけるその応用

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Papers (26)：

Daisuke Yoshioka, Takanori Nakamura, Yuji Kubota, Mutsuhiro Takekawa. Formation of the NLRP3 inflammasome inhibits stress granule assembly by multiple mechanisms. The Journal of Biochemistry. 2024. mvae009
Daichi Fujikawa, Takanori Nakamura, Daisuke Yoshioka, Zizheng Li, Hisashi Moriizumi, Mari Taguchi, Noriko Tokai-Nishizumi, Hiroko Kozuka-Hata, Masaaki Oyama, Mutsuhiro Takekawa. Stress granule formation inhibits stress-induced apoptosis by selectively sequestering executioner caspases. Current Biology. 2023. 33. 1967-1981
Nakamura, Takanori, Tokai, Noriko, Nakazawa, Takashi, Mori, Tatsuki, Suzuki, Takashi, Takekawa, Mutsuhiro. Mathematical analysis of the mechanism of how centriole biogenesis regulators are transported to mother centrioles. The 81st Annual Meeting of Japanese Cancer Association. 2022. 113. E6-1
Takanori Nakamura. SAPK-regulated microRNA-X suppresses apoptosis in colorectal cancer. Cancer Science. 2022
Nakamura Takanori, Nishizumi-Tokai Noriko, Nakazawa Takashi, Mori Tatsuki, Suzuki Takashi, Takekawa Mutsuhiro. Mathematical modeling of the molecular mechanism underlying the recruitment of centriole biogenesis regulators to mother centrioles. The 80th Annual meeting of Japanese Cancer Association. 2021

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MISC (47)：

Functional analysis of miRNA-X, whose expression is regulated by SAPK, in colorectal cancer. 2024. 1P-838
Elucidation of the stress response mechanism through spatiotemporal regulation of SAPKK. 2024. 1P-462 (1MS-02-06)
Analysis of BCR-ABL drug-responsive interactions that induce chronic myeloid leukemia (CML). 2024. 1P-818
Comprehensive understanding of BCR-ABL interactome in CML using proximity-dependent biotin labeling. 2024. 2P-828
中村貴紀, 山内陽生, 山田航大, 小迫英尊, 増本純也, 澤崎達也. 近位依存性タンパク質間相互作用から迫る慢性骨髄性白血病 (CML) 病態の包括的理解と新規創薬標的分子の探索. 第20回日本病理学会カンファレンス. 2024. P16

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Books (2)：

ストレス顆粒形成による生命機能制御と疾患
羊土社実験医学増刊「相分離-メカニズムと疾患-」 2021
JNK/p38-AP1経路とストレス反応系
日本臨床増刊「分子標的薬:がんから他疾患までの治癒をめざして」 2012

Lectures and oral presentations (22)：

SAPKKの時空間制御による生体ストレス応答機構の解明
(第47回日本分子生物学会 1MS-02-06(1P-462) 2024)
非膜型細胞内小器官の観点から捉える生体内恒常性の維持機構
(第301回愛媛大学応用化学セミナー 2023)
Mathematical model of mTORC1 pathway sensing intracellular amino-acids and glucose
(10th International Congress on Industrial and Applied Mathematics (ICIAM2023 Tokyo) 0114-4D-04349 2023)
発育不全疾患の発症メカニズムの解明と神経変性疾患治療を目指した取り組み
(PROS第1回合同教員会議ショートセミナー 2023)
mTORC1経路
(2022年度数理腫瘍学年末研究会 2022)

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Education (3)：

2008 - 2013 The University of Tokyo
2006 - 2008 The University of Tokyo
2002 - 2006 Tokyo University of Science Faculty of Pharmaceutical Sciences Department of Pharmacy

Professional career (1)：

Ph.D. (The University of Tokyo)

Work history (6)：

2024/04 - 現在 Ehime University Department of Pathology, Graduate School of Medicine Senior Assistant Professorssor
2024/04 - 現在愛媛大学プロテオサイエンスセンター病理学部門(増本純也教授) 特定講師
2023/04 - 2024/03 Ehime University Division of Cell-Free Science, Proteo-Science Center Senior Assistant Professor
2013/04 - 2023/03 University of Tokyo The Institute of Medical Science Assistant Professor
2012/04 - 2013/03 The University of Tokyo The Institute of Medical Science Research Associate

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Committee career (5)：

2022/09 - 現在 Cancer Science誌 Peer Reviewer
2021/12 - 現在 AIMS Bioengineering誌 Peer Reviewer
2017/09 - 現在 American Society of Cell Biology (ASCB) Ambassador
2023/04 - 2023/05 日本生化学会中国四国支部例会実行委員
2020/04 - 2023/03 東京大学医科学研究所広報委員

Awards (12)：

2024/02 - 高松宮妃癌研究基金研究助成
2020/12 - Mochida Memorial Foundation for Medical and Pharmaceutical Research Grant-in-aid for Research
2019/08 - Takeda Science Foundation Grant-in-aid for Research
2019/06 - Japan Society for Cell Biology Young Scientist's Award
2018/03 - The Uehara Memorial Foundation Grant-in-aid for Research

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Association Membership(s) (7)：

日本病理学会 , American Society of Cell Biology (ASCB) , Japanese Society for Molecular Medicine , JAPAN SOCIETY FOR CELL BIOLOGY , THE JAPANESE CANCER ASSOCIATION , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE BIOCHEMICAL SOCIETY

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