Yanagie Hironobu

ヤナギエヒロノブ | Yanagie Hironobu

Affiliation and department：
Job title： Visiting Researcher
Other affiliations (1)：

新潟薬科大学健康・自立総合研究機構特別招聘教授

Research field (7)： General surgery, pediatric surgery , Quantum beam science , Radiology , Radiology , Gastroenterology , Clinical pharmacy , Tumor biology

Research keywords (5)：ナノミセル , リポソーム , WOWエマルション , 中性子捕捉療法 , ドラッグデリバリーシステム

Research theme for competitive and other funds (28)：

2021 - 2023 Development of Neutron Capture Therapy using intra-nucleus Gadolinium delivery to refractory scirrhous carcinoma
2021 - 2023 RIプローブと蛍光プローブの差異を明らかにするための薬剤挙動に関する動態解析
2018 - 2020 Development of Boron-Albumin Delivery Systems for Neutron Capture Therapy to Refractory Solid Cancer
2013 - 2016 Development of cancer specific Gd neutron capture therapy using membrane fusion protein & nuclear locarization signal
2012 - 2016 Development of neutron capture therapy using intra-arterial injection of cancer specific emulsion by membrane emulsification technique

2011 - 2012 Development of Intelligent Gadorinium Neutron Capture Therapy asCancer Specific Atomic Suppression Therapy

2009 - 2010 癌特異的原子抑制治療としてのインテリジェントGdデリバリーシステムの開発

2006 - 2008 Development of molecular targeting therapy using cancer permeabile WOW emulsion by membrane emulfication

2005 - 2006 癌特異的トランスポーターを利用したインテリジェントDDSによる癌分子標的治療

2005 - 2006 抗癌活性を示すポリ酸を基盤とする医薬品の開発

2004 - 2005 機能性微粒子に制御させる次世代抗癌剤のナノアッセンブリ的合成と選択的デリバリー

2004 - 2005 Development of Molecular Targeting Agents Based on Analysis Oncogenesis with Homeobox Gene Mutation

2003 - 2004 トランスポーターを応用したインテリジェントDDSによる癌分子標的治療

2003 - 2004 Cell Specific Gene Delivery Systems with DNA Complexes Coated by Sugar-bearing Polyanions

2003 - 2004 Development of Gene Therapy with Nanotechnology derived Intelligent Drug Deliver Systems

2001 - 2003 Development of novel synthetic gene delivery systems with an ability to fuse with cells

2001 - 2003 Molecular Targeting Therapy with Intelligent Drug Delivery System using Transporter

2001 - 2003 Clinical Application of Tumor-specific Anti-tumor Immunity Induced by Tumor Cells Expressing Fas (CD95) Ligand

2001 - 2003 Development of intracellular targeting liposomes for boron neutron-capture therapy

2000 - 2001 遺伝子治療用インテリジェント・リポソームシステムの開発

1999 - 2001 International Collaboration for Application of Boron Neutron Capture Therapy to Intraoperative Irradiational Therapy

1999 - 2001 Development of New Strategy of Boron Neutron Capture Therapy to Cancer Combined with Tumor Specific Gene Delivery

1998 - 2000 Application of Intelligent Targeting System for Cancer Gene Therapy

1998 - 1999 肝細胞癌における腫瘍ワクチンおよびTRAILを用いた腫瘍特異的遺伝子治療

1996 - 1998 癌抑制遺伝子による膵癌治療の基礎的研究

1996 - 1996 深在性放射線低抗性腫瘍に対する熱・熱外中性子捕捉療法の開発

1995 - 1996 INVESTIGATION OF SPONTANEOUS LIVER METASTASIS MODEL OF BALB/c REIROPERITONEAL SARCOMA (LMFS) AND CLINICAL APPLICATION

1992 - 1993 Application of monoclonal antibody against solid tumor to boron neutron capture therapy model

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Papers (88)：

HIRONOBU YANAGIE, MASASHI YANAGAWA, YASUYUKI MORISHITA, ATSUKO SHINOHARA, NOVRIANA DEWI, YASUMASA NONAKA, YOSHITAKA FURUYA, RYOUJI MIZUMACHI, YUUJI MURATA, HIROYUKI NAKAMURA, et al. Suppression of Tumor Growth in a Rabbit Hepatic Cancer Model by Boron Neutron Capture Therapy With Liposomal Boron Delivery Systems. In Vivo. 2021. 35. 6. 3125-3135
HIRONOBU YANAGIE, TAKASHI FUJINO, MASASHI YANAGAWA, TOSHIMITSU TERAO, TAKASHI IMAGAWA, MITSUTERU FUJIHARA, YASUYUKI MORISHITA, RYOUJI MIZUMACHI, YUUJI MURATA, NOVRIANA DEWI, et al. Tumor Growth Suppression With Novel Intra-arterial Chemotherapy Using Epirubicin-entrapped Water-in-oil-in-water Emulsion In Vivo. In Vivo. 2021. 35. 1. 239-248
柳衛佳輝, 柳衛宏宣, 侯鉉, 柳川将志, 石川達矢, ノブリアナ・デヴィ, 森下保幸, 松川岳久, 久保田章乃, 鈴木実, et al. ガドリニウム陽荷電複合体の中性子捕捉療法における腫瘍増殖抑制効果の検討. 日本癌治療学会学術集会抄録集. 2020. 58回. P-450
Hironobu Yanagie, Masashi Yanagawa, Tsuyoshi Higuchi, Ryouji Mizumachi, Mitsuteru Fujihara, Yasuyuki Morishita, Yuriko Sakurai, Kikue Mouri, Novriana Dewi, Yasumasa Nonaka, et al. Single-dose toxicity study by intra-arterial injection of 10BSH entrapped water-in-oil-in-water emulsion for boron neutron capture therapy to hepatocellular carcinoma. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 2020. 163. 109202-109202
Changyuan Qin, Xuan Hou, Thahomina Khan, Nobuhiro Nitta, Masashi Yanagawa, Yuriko Sakurai, Minoru Suzuki, Shin Ichiro Masunaga, Hiroki Tanaka, Yoshinori Sakurai, et al. Enhanced MRI-Guided Gadolinium (III) Neutron Capture Therapy by Polymeric Nanocarriers Promoting Tumor Accumulation and Intracellular Delivery. ChemNanoMat. 2020. 6. 3. 412-419

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MISC (51)：

Hou Xuan, 柳衛宏宣, 柳衛宏宣, 柳衛宏宣, 松川岳久, 久保田章乃, Yang Daibing, 柳川将志, 山口治雄, 小野稔, et al. An Attempt to a New Neutron Capture Therapy Using Rhodium-The Anti-tumor Method Based on Beta Ray. RADIOISOTOPES (Web). 2024. 73. 1
松川岳久, 久保田章乃, 柳衛宏宣, 柳川将志, 平田岳史, 篠原厚子, 横山和仁. LA-ICP-MSによるガドリニウム157中性子捕捉製剤の定量的バイオイメージング. 日本衛生学雑誌. 2019. 74. Suppl. S129-S129
鈴木実, 高垣雅緒, 宮武伸一, 平塚純一, 櫻井英幸, 柳衛宏宣, 東治人, 中村浩之, 谷森紳治, 安藤徹, et al. BNCT実用化に向けた橋渡し研究. KURRI-EKR (Web). 2016. 16. ROMBUNNO.PJ2 (WEB ONLY)
柳衛宏宣, 中村剛実, 堀口洋徳, 熊田博明, 鈴木実, 櫻井良憲, 田中浩基, 増永慎一郎, 丸橋晃, 小野公二, et al. 再発乳癌への中性子捕捉療法の応用に向けた熱中性子線ドジメトリーの検討. 第12回日本中性子捕捉療法学会学術大会. 2015
柳衛宏宣, 東秀史, 生島一朗, 藤原光輝, 柳川将志, 森下保幸, 篠原厚子, 由井翔, 田中浩基, 櫻井良憲, et al. 原発性肝臓癌に対する中性子捕捉療法に応用するWOWエマルションについての検討. 第12回日本中性子捕捉療法学会学術大会. 2015

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Books (1)：

Application of Neutron Capture Therapy for Local Recurrenced Breast Cancer and Inflammatory Breast Cancer
2012

Education (2)：

1990 - 現在東京大学大学院医学研究科修了
1984 - 現在 Kochi Medical School

Professional career (1)：

医学博士

Work history (12)：

2017/07 - 現在 Niigata University of Pharmacy and Applied Life Sciences Research Institute for Healthy Living
2017/04 - 現在 The University of Tokyo The Graduate School of Engineering, Department of Nuclear Engineering and Management
2013/10 - 2017/03 Meiji Pharmaceutical University
2011/12 - 2013/09 The University of Tokyo The Graduate School of Engineering, Department of Nuclear Engineering and Management
2006/12 - 2011/12 The University of Tokyo The Graduate School of Engineering, Department of Nuclear Engineering and Management

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Committee career (3)：

2007 - 現在日本中性子捕捉療法学会幹事
2009 - 2011 日本胃癌学会評議員
2002 - 2007 遺伝子・デリバリー研究会評議員

Awards (3)：

2005 - Best Poster Award DNA Microarray Analysis Specific to Chemikine /Ckemokine Receptor as the Marker of Metasis in Gastric Cancer Cell Lines.
2003 - 財団法人がん研究振興財団研究奨励賞
1999 - 財団法人持田記念医学薬学振興財団研究奨励賞

Association Membership(s) (13)：

アメリカ癌学会(AACR) , 遺伝子・デリバリー研究会 , 日本DDS学会 , 日本中性子捕捉療法学会 , 国際中性子捕捉療法学会 , 国際胃癌学会 , 日本胃癌学会 , 日本乳癌学会 , 日本癌治療学会 , 日本癌学会 , 日本消化器内視鏡学会 , 日本消化器外科学会 , 日本外科学会

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