Takuro Iwao

イワオタクロウ | Takuro Iwao

Affiliation and department：
Job title： Assistant Professor

Research field (1)： Clinical pharmacy

Research keywords (2)： Pharmacokinetics , Blood-Brain Barrier

Research theme for competitive and other funds (7)：

2023 - 2026 Chronotherapeutic strategy for Parkinson's disease by intranasal administration of human iPS-derived brain pericytes
2022 - 2025 加熱式たばこ主流煙抽出物による脳血管および中枢神経障害の発現リスク評価
2022 - 2025 病変型脳ペリサイトのαシヌクレイン処理能障害による頭部外傷後のパーキンソン病発症
2022 - 2023 オリゴデンドロサイト前駆細胞のnAChRを標的とした多発性硬化症治療法の創出
2021 - 2023 加齢生薬物輸送担体機能変調によるBBB薬物動態変動の解明とその改善法開発

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Papers (5)：

Takuro Iwao, Fuyuko Takata, Junichi Matsumoto, Yuki Goto, Hisataka Aridome, Miho Yasunaga, Miki Yokoya, Yasufumi Kataoka, Shinya Dohgu. Senescence in brain pericytes attenuates blood-brain barrier function in vitro: A comparison of serially passaged and isolated pericytes from aged rat brains. Biochemical and biophysical research communications. 2023. 645. 154-163
Takuro Iwao, Fuyuko Takata, Junichi Matsumoto, Hisataka Aridome, Miho Yasunaga, Miki Yokoya, Yasufumi Kataoka, Shinya Dohgu. Aging decreases docosahexaenoic acid transport across the blood-brain barrier in C57BL/6J mice. PloS one. 2023. 18. 2. e0281946
Junichi Matsumoto, Shinya Dohgu, Fuyuko Takata, Takuro Iwao, Ikuya Kimura, Misaki Tomohiro, Kentaro Aono, Yasufumi Kataoka, Atsushi Yamauchi. Serum amyloid A-induced blood-brain barrier dysfunction associated with decreased claudin-5 expression in rat brain endothelial cells and its inhibition by high-density lipoprotein in vitro. Neuroscience letters. 2020. 738. 135352-135352
Ikuya Kimura, Shinya Dohgu, Fuyuko Takata, Junichi Matsumoto, Takuya Watanabe, Takuro Iwao, Atsushi Yamauchi, Yasufumi Kataoka. Oligodendrocytes upregulate blood-brain barrier function through mechanisms other than the PDGF-BB/PDGFRα pathway in the barrier-tightening effect of oligodendrocyte progenitor cells. Neuroscience letters. 2020. 715. 134594-134594
Fuyuko Takata, Shinya Dohgu, Shinya Sakaguchi, Kenta Sakai, Gaku Yamanaka, Takuro Iwao, Junichi Matsumoto, Ikuya Kimura, Yume Sezaki, Yoshie Tanaka, et al. Oncostatin-M-Reactive Pericytes Aggravate Blood-Brain Barrier Dysfunction by Activating JAK/STAT3 Signaling In Vitro. Neuroscience. 2019. 422. 12-20

Books (2)：

αシヌクレインによる血液脳関門障害
CLINICAL NEUROSCIENCE 2022
頭部外傷後の脳ペリサイト応答異常と血液脳関門障害
CLINICAL NEUROSCIENCE 2022

Lectures and oral presentations (37)：

Brain Transport of Non-Esterified Docosahexaenoic Acid Across the Blood-Brain Barrier is Decreased in Middle-Aged and Aged Mice
(2022)
血液脳関門を介した非エステル型ドコサヘキサエン酸の脳移行は加齢に伴い減少する
(第75回日本薬理学会西南部会 2022)
BMP拮抗物質nogginは頭部外傷によるfibrinogen脳内漏出を抑制する
(日本薬学会第142年会 2022)
加熱式たばこPloom TECH®抽出物が脳血管内皮細胞のトランスポーター発現と細胞内情報伝達におよぼす影響
(日本薬学会第142年会 2022)
Involvement of P-glycoprotein in α-synuclein aggregate-induced inflammatory mediator release by brain pericytes
(4 th Mini-Symposium on the Blood-Brain Barrier from Basic to Clinical Research 2022)

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Education (2)：

2019 - 2023 Fukuoka University Faculty of Pharmaceutical Sciences
2010 - 2016 Fukuoka University 薬学部薬学科

Professional career (1)：

博士(薬学) (福岡大学薬学部薬学研究科)

Work history (3)：

2019/04/01 - 福岡大学薬学部応用薬剤学教室
2018/04/01 - 2019/03/31 独立行政法人国立病院機構九州がんセンター
2016/04/01 - 2018/03/31 独立行政法人国立病院機構沖縄病院

Awards (1)：

2022/11 - 第96回年会優秀ポスター賞 Brain Transport of Non-Esterified Docosahexaenoic Acid Across the Blood-Brain Barrier is Decreased in Middle-Aged and Aged Mice

Association Membership(s) (3)：

日本薬理学会 , 日本医療薬学会 , 日本薬学会

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