Atsushi Fukuda

Affiliation and department：

Research field (1)： Developmental biology

Research theme for competitive and other funds (11)：

2024 - 2027 Elucidation of the molecular mechanisms of selective neurodegeneration focusing on the cell-type-specific resilience regulatory systems
2022 - 2025 ヒトiPS/ES細胞を用いたゲノム脆弱性変異リスクのpseudo-score化
2021 - 2024 新的遺伝子量補正法による性特異的X連鎖難治疾患iPS細胞を用いた脳神経病態モデリングに関する研究開発
2020 - 2024 生命発動と器官発生・制御に関わるヒト受精胚分子機序の解明
2020 - 2023 De novo DNAメチル化の消去が及ぼすヒトES/iPS細胞の初期胚化の検証

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Papers (26)：

Nami Motosugi, Akiko Sugiyama, Asako Otomo, Yuka Sakata, Takuma Araki, Shinji Hadano, Natsuhiko Kumasaka, Atsushi Fukuda. Effect of PCDH19 missense mutations on cell-to-cell proximity and neuronal development under heterotypic conditions. PNAS nexus. 2024. 3. 3. pgae060
Yuka Sakata, Hong Zhang, Akiko Sugiyama, Nami Motosugi, Hiroshi Kimura, Yosuke Okamura, Atsushi Fukuda. Nanosheet coating improves stability of human pluripotent stem cell culture on glass substrates. Biochemical and biophysical research communications. 2023. 650. 55-61
Nami Motosugi, Akiko Sugiyama, Chisa Okada, Asako Otomo, Akihiro Umezawa, Hidenori Akutsu, Shinji Hadano, Atsushi Fukuda. De-erosion of X chromosome dosage compensation by the editing of XIST regulatory regions restores the differentiation potential in hPSCs. Cell Reports Methods. 2022. 100352-100352
Atsushi Fukuda, Dane Z Hazelbaker, Nami Motosugi, Jin Hao, Francesco Limone, Amanda Beccard, Patrizia Mazzucato, Angelica Messana, Chisa Okada, Irune Guerra San Juan, et al. De novo DNA methyltransferases DNMT3A and DNMT3B are essential for XIST silencing for erosion of dosage compensation in pluripotent stem cells. Stem cell reports. 2021. 16. 9. 2138-2148
Nami Motosugi, Chisa Okada, Akiko Sugiyama, Tomoyuki Kawasaki, Minoru Kimura, Takashi Shiina, Akihiro Umezawa, Hidenori Akutsu, Atsushi Fukuda. Deletion of lncRNA XACT does not change expression dosage of X-linked genes, but affects differentiation potential in hPSCs. Cell reports. 2021. 35. 10. 109222-109222

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