2019 - 2022 Development of atropine esterase formulation to improve the effect of atropine used in the anesthesiology field
2019 - 2022 Identification of Novel Molecular Targets and Drug Development by Genomic and Multilayer-Omics Analysis of Hereditary Cardiomyopathies
2018 - 2021 Elucidation of the mechanism in which mechanostress modulates cardiac microtubules dynamics
2018 - 2021 Development and clinical application of low molecular chemicals that modulate myosin light chain kinase for the treatment of heart failure with preserved ejection fraction
2017 - 2020 Analysis of the regulatory mechanism of the activity of cardiac specific myosin light chain kinase
2015 - 2018 Elucidation of the irreversible mechanism of severe heart failure using biological monitoring murine heart failure model
2015 - 2018 A novel AMPK singaling at the intercalated disc in heart
2015 - 2018 Elucidation of the regulatory mechanism of natriuretic hormone expression for oral heart failure drug development
2014 - 2017 anti-atherosclerotic and anti-cancer effects of AMPK activation
2013 - 2016 Exploration for Aggravating Process of Heart Failure Induced by Specific Interaction with G-protein-coupled Receptor and Toll-like Receptor
2014 - 2015 Development of simple and noninvasive method to assess the severity of heart failure
2012 - 2015 A New Diagnostics Method for Refractory Heart Failure
2012 - 2015 Role of ER oxidoreductin-1 in cardiovascular remodeling
2010 - 2011 Identification of cardiomyocyte-specific transcriptional mechanism of c-myc
2008 - 2010 Identification and Functional Analysis of Cardiac Specific Singling Molecules and Therapeutic Applications for Cardiovascular Disease
2005 - 2006 心不全の病態における小胞体ストレス誘導性心筋細胞アポトーシスの重要性
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Papers (70):
Shinji Tokuyama, Hisakazu Kato, Hidekazu Takahashi, Kyoko Ueda, Asami Arita, Ryuta Ueda, Hiroto Seto, Yuki Sekido, Tsuyoshi Hata, Atsushi Hamabe, et al. BRAF V600E-induced distinct DNA damage response defines the therapeutic potential of p53 activation for TP53 wild-type colorectal cancer. Carcinogenesis. 2024
Chisato Okamoto, Osamu Tsukamoto, Takuya Hasegawa, Ken Matsuoka, Makoto Amaki, Hideaki Kanzaki, Chisato Izumi, Seiji Takashima, Shin Ito, Masafumi Kitakaze. Relative B-Type Natriuretic Peptide Deficiency May Exist in Diastolic Dysfunction in Subclinical Population. Circulation Reports. 2024. 6. 5. 151-160
Chisato Okamoto, Osamu Tsukamoto, Takuya Hasegawa, Ken Matsuoka, Makoto Amaki, Hideaki Kanzaki, Chisato Izumi, Seiji Takashima, Shin Ito, Masafumi Kitakaze. Association Between B-Type Natriuretic Peptide Deficiency and Left Ventricular Concentric Hypertrophy in Subclinical Individuals. JACC: Asia. 2024
Osamu Tsukamoto, Seiji Takashima. Response by Tsukamoto and Takashima to Letter Regarding Article, "Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Super-Relaxed Myosin". Circulation. 2023. 148. 25. 2074-2075
Hiroshi Kishimoto, Masayoshi Iwasaki, Kensaku Wada, Keita Horitani, Osamu Tsukamoto, Kenta Kamikubo, Seitaro Nomura, Shinji Matsumoto, Takeshi Harada, Daisuke Motooka, et al. Wnt5a-YAP signaling axis mediates mechanotransduction in cardiac myocytes and contributes to contractile dysfunction induced by pressure overload. iScience. 2023. 107146-107146