Rchr
J-GLOBAL ID：202001000167535999
Update date: Nov. 26, 2024
Otsuka Kensuke
オオツカ ケンスケ | Otsuka Kensuke
Affiliation and department：
Research field (7)：
Applied biofunctional and bioprocess engineering
, Molecular biology
, Molecular biology
, Applied molecular and cellular biology
, Biomedical engineering
, Developmental biology
, Molecular biology
Research keywords (9)：
ラボオートメーション
, ライトシート顕微鏡
, 組織透明化
, 環境因子
, Next-generation sequencing
, ライブセルイメージング
, organoids
, 消化管
, 組織幹細胞
Research theme for competitive and other funds (5)：
- 2024 - 2028 環境因子に共通するゲノムストレスと炎症の臓器・オルガノイドイメージング
- 2019 - 2023 mTert幹細胞に特異的な遺伝子の解析による幹細胞休止性と放射線抵抗性の理解
- 2012 - 2017 Role of non-homologous end joining in biological response under low dose-rate irradiation condition
- 2013 - 2016 Quantitative evaluation of radiation-induced response on tissue stem cells
- 2011 - 2012 Establishment of spatio-temporal analysis for low-dose-rateradiation-induced damage accumulation in tissue stem cells
Papers (15)：
-
Kohei Otomo, Takaki Omura, Yuki Nozawa, Steven J. Edwards, Yukihiko Sato, Yuri Saito, Shigehiro Yagishita, Hitoshi Uchida, Yuki Watakabe, Kiyotada Naitou, et al. descSPIM: an affordable and easy-to-build light-sheet microscope optimized for tissue clearing techniques. Nature Communications. 2024. 15. 4941
-
Kensuke Otsuka, Toshiyasu Iwasaki. Insights into radiation carcinogenesis based on dose-rate effects in tissue stem cells. International Journal of Radiation Biology. 2023. 99. 10. 1503-1521
-
Yuki Fujimichi, Kensuke Otsuka, Masanori Tomita, Toshiyasu Iwasaki. Ionizing radiation alters organoid forming potential and replenishment rate in a dose/dose-rate dependent manner. Journal of radiation research. 2022. 63. 2. 166-173
-
Yuki Fujimichi, Kensuke Otsuka, Masanori Tomita, Toshiyasu Iwasaki. An Efficient Intestinal Organoid System of Direct Sorting to Evaluate Stem Cell Competition in Vitro. Scientific Reports. 2019. 9. 1
-
Kensuke Otsuka, Masanori Tomita. Concurrent live imaging of DNA double-strand break repair and cell-cycle progression by CRISPR/Cas9-mediated knock-in of a tricistronic vector. Scientific reports. 2018. 8. 1. 17309-17309
ｍore...
MISC (14)：
-
大塚健介, 内之宮光紀. Live-cell imaging and mathematical modeling to understand the fitness of cells with different degrees of DNA damage. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
-
大塚健介. Imaging-based DNA damage responses in whole-body and organoids. Journal of Toxicological Sciences. 2023. 48. Supplement (CD-ROM)
-
大塚健介. Live-cell imaging of DNA damage responses: interpretation from organoids to whole body. Journal of Toxicological Sciences. 2022. 47. Supplement (CD-ROM)
-
大塚健介, 藤通有希. Challenges to radiation biology using organoids and live-cell imaging. 放射線生物研究. 2021. 56. 2. 224-235
-
大塚健介. A new mouse model for imaging of genomic stress in organs. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
ｍore...
Education (1)：
Work history (5)：
- 2021/07 - 現在 Central Research Institute of Electric Power Industry
- 2019/07 - 2021/06 Central Research Institute of Electric Power Industry
- 2007/08 - 2019/06 一般財団法人電力中央研究所 原子力技術研究所 放射線安全研究センター 主任研究員
- 2018/04 - 2019/03 Boston Children's Hospital / Harvard Medical School, Division of Endocrinolgy, Research Fellow
- 2003/04 - 2007/07 財団法人電力中央研究所 低線量放射線研究センター 研究員
Association Membership(s) (3)：
Return to Previous Page
