Umegawa Yuichi

Affiliation and department：

Research field (4)： Bioorganic chemistry , Chemical biology , Molecular biochemistry , Molecular biology

Research keywords (3)：天然物化学 , 脂質二重膜 , 固体NMR

Research theme for competitive and other funds (9)：

2023 - 2026 多価不飽和脂肪酸結合脂質の動態解析を目指した相分離系の構築と解析
2021 - 2025 Chemical study on dynamics of model lipid bilayers reproducing biomembrane under non-equilibrium conditions
2020 - 2023 ネクロトーシス課程にて長鎖脂肪酸が膜物性に与える影響
2016 - 2021 Dynamic conformation and domain structure of lipid molecules in model biomembranes
2013 - 2017 Exploration of natural products and small molecues for mode-of-action study on biomembrane lipids

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Papers (35)：

Yuichi Umegawa, Sho Kato, Sangjae Seo, Wataru Shinoda, Satoshi Kawatake, Shigeru Matsuoka, Michio Murata. Protein-lipid acyl chain interactions: Depth-dependent changes of segmental mobility of phospholipid in contact with bacteriorhodopsin. Biophysical chemistry. 2024. 308. 107204-107204
Yuichi Umegawa, Michio Murata, Shiho Fukunaga, Tomokazu Yasuda. A Fluorescent Probe for C24 Fatty Acids to Report the Deep Interior of Lipid Bilayers. Synlett. 2023
Michio Murata, Yuichi Umegawa, Shinya Hanashima. NMR Studies on the Structure and Functions of Small Biomolecules with Highly Flexible Conformation. Bulletin of the Chemical Society of Japan. 2023. 96. 10. 1156-1168
Joan Candice Ondevilla, Shinya Hanashima, Akane Mukogawa, Darcy Garza Miyazato, Yuichi Umegawa, Michio Murata. Effect of the number of sugar units on the interaction between diosgenyl saponin and membrane lipids. Biochimica et biophysica acta. Biomembranes. 2023. 1865. 5. 184145-184145
Yuichi Umegawa, Satoshi Kawatake, Michio Murata, Shigeru Matsuoka. Combined effect of the head groups and alkyl chains of archaea lipids when interacting with bacteriorhodopsin. Biophysical chemistry. 2023. 294. 106959-106959

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Books (1)：

Lectures and oral presentations (13)：

Solid-state NMR measurements of amphotericin B, a natural product that interacts with lipid bilayers
(2022)
Diosgenin-induced physicochemical effects on phospholipid bilayers in comparison with cholesterol
(Bioorganic & Medicinal Chemistry Letters 2021)
Structural Basis for Membrane Receptor Activity of Ganglioside GM3 Regulated by Lipid-Lipid Interactions
(日本化学会春季年会講演予稿集(Web) 2021)
Elucidation of inter-leaflet coupling in asymmetric membranes induced by very long chain sphingomyelin based on solid-state NMR
(日本化学会春季年会講演予稿集(Web) 2021)
Natural products and membrane lipids interplay responsible for biological activities
(日本農芸化学会大会講演要旨集(Web) 2021)

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Education (3)：

Work history (9)：

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Awards (2)：

Association Membership(s) (3)：

リサーチ・アドミニストレーション協議会 , 日本核磁気共鳴学会 , 日本化学会

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