Research field (3)：
Pharmacology
, Metabolism and endocrinology
, Nutrition and health science
Research keywords (2)：
メタボロミクス
, NAD metabolism
Research theme for competitive and other funds (4)：
2022 - 2025 Diverse origins and roles of osteoclasts in bone homeostasis and disease
2021 - 2024 サルコペニアの予防・治療に向けたNAD代謝によるアミノ酸吸収調節機構の解明
2018 - 2021 Elucidation of novel NAD synthesis pathway to develop anti-aging strategy
2016 - 2018 Elucidation of transportation mechanism of NAD precursors
Papers (33)：
Mathieu Membrez, Eugenia Migliavacca, Stefan Christen, Keisuke Yaku, Jennifer Trieu, Alaina K. Lee, Francesco Morandini, Maria Pilar Giner, Jade Stiner, Mikhail V. Makarov, et al. Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia. Nature Metabolism. 2024
Miyuki Nomura, Mai Ohuchi, Yoshimi Sakamoto, Kei Kudo, Keisuke Yaku, Tomoyoshi Soga, Yuki Sugiura, Mami Morita, Kayoko Hayashi, Shuko Miyahara, et al. Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma. Nature Communications. 2023. 14. 1
Shintaro Yamaguchi, Daiki Kojima, Tooba Iqbal, Shotaro Kosugi, Michael P Franczyk, Nathan Qi, Yo Sasaki, Keisuke Yaku, Kenji Kaneko, Kenichiro Kinouchi, et al. Adipocyte NMNAT1 expression is essential for nuclear NAD+ biosynthesis but dispensable for regulating thermogenesis and whole-body energy metabolism. Biochemical and biophysical research communications. 2023. 674. 162-169
Keisuke Yaku, Takashi Nakagawa. NAD+ Precursors in Human Health and Disease: Current Status and Future Prospects. Antioxidants & redox signaling. 2023
2019/10 - 現在 University of Toyama Department of Molecular and Medical Pharmacology, Faculty of Medicine
2016/04 - 2019/09 University of Toyama Department of Metabolism and Nutrition, Graduate School of Medicine and Pharmaceutical Science for Research
2015/04 - 2016/03 University of Toyama Frontier Research Core for Life Sciences
2014/05 - 2015/02 University of Iowa Department of Biochemistry postdoctoral researcher
Awards (5)：
2022/11 - The Japanese Pharmacological Society The 96th Annual Meeting of the Japanese Pharmacological Society Poster Award Inhibition of CD38 promotes muscle regeneration
2021/12 - 富山大学 医学部長賞
2013/09 - 大阪市立大学 学長奨励賞
2011/10 - 日本栄養食糧学会近畿支部 若手研究者奨励賞
2011/10 - Society for Free Radical Research International Young Investigators Award
