Konno Sho

コンノショウ | Konno Sho

Affiliation and department：
Job title：助教

Research field (3)： Chemical biology , Pharmaceuticals - chemistry and drug development , Bioorganic chemistry

Research keywords (6)： Chemical Biology , 生物有機化学 , Biosynthesis , Natural product chemistry , Cyclic peptide , Hydrolytic enzyme

Research theme for competitive and other funds (5)：

2023 - 2026 Development of innovative drug discovery based on SARS-CoV-2 3CL protease inhibitor YH-53
2023 - 2026 Development of transition-state analogs for peptide macrocyclases
2021 - 2023 Characterization of a tandem-macrocyclase in nonribosomal peptide synthetases
2020 - 2022 Development of a degrader for SARS-CoV-2 3CL protease
2015 - 2017 アデニレーションドメインに対するテーラーメイドケミカルラベリング法の開発

Papers (25)：

Sho Konno, Fumihiro Ishikawa, Hideaki Kakeya, Genzoh Tanabe. Probing for optimal photoaffinity linkers of benzophenone-based photoaffinity probes for adenylating enzymes. Bioorganic & Medicinal Chemistry. 2024
Yuki Yamauchi, Sho Konno, Noriko Omura, Narumi Yoshioka, Alexandra Hingst, Michael Gütschow, Christa E. Müller, Akihiro Taguchi, Atsuhiko Taniguchi, Atsushi Kawaguchi, et al. Detection of Active SARS-CoV-2 3CL Protease in Infected Cells Using Activity-Based Probes with a 2,6-Dichlorobenzoyloxymethyl Ketone Reactive Warhead. ACS Chemical Biology. 2024
Fumihiro Ishikawa, Sho Konno, Hideaki Kakeya, Genzoh Tanabe. Development of a chemical scaffold for inhibiting nonribosomal peptide synthetases in live bacterial cells. Beilstein Journal of Organic Chemistry. 2024
Noriko Omura, Akihiro Taguchi, Tomoki Kuwahara, Keisuke Hamada, Mizuki Watanabe, Masanori Nakakuki, Sho Konno, Kentaro Takayama, Atsuhiko Taniguchi, Toshifumi Nomura, et al. Development of Conformationally Restricted Negamycin Derivatives for Potent Readthrough Activity. ACS Medicinal Chemistry Letters. 2023
Sho Konno, Miyu Tanaka, Tomoe Mizuguchi, Haruka Toyokai, Akihiro Taguchi, Atsuhiko Taniguchi, Yoshio Hayashi. Peptide mixed phosphonates for covalent complex formation with thioesterases in nonribosomal peptide synthetases. Journal of peptide science. 2023. e3532

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MISC (13)：

向山海凪, 内山千尋, 福田茜, 倉持由佳, 松垣直宏, 千田俊哉, 谷口敦彦, 今野翔, 林良雄, 南雲陽子, et al. 環状ペプチドMA026のTJ開口活性の作用機構解析. 日本農芸化学会関東支部講演要旨集(CD-ROM). 2021. 2021
坂田萌, 田口晃弘, 倉石彩恵香, 今野翔, 高山健太郎, 高山健太郎, 谷口敦彦, 林良雄. One-pot synthesis of cyclic disulfide peptide with water-soluble Npys derivative. 日本薬学会年会要旨集(Web). 2021. 141st
岡本英之, 谷口敦彦, 宇佐美翔哉, 勝山雅大, 今野翔, 田口晃弘, 高山健太郎, 高山健太郎, 林良雄. 光酸素化能を付与した機能化ペプチドによるマイオスタチンの活性阻害. 創薬懇話会講演要旨集. 2021. 2021
坂田萌, 田口晃弘, 倉石彩恵香, 今野翔, 高山健太郎, 高山健太郎, 谷口敦彦, 林良雄. 水溶性Npys誘導体を用いたジスルフィドペプチドの効率的合成法開発. 創薬懇話会講演要旨集. 2021. 2021
澤田直志, 大村紀子, 浜田圭佑, 今野翔, 田口晃弘, 高山健太郎, 高山健太郎, 谷口敦彦, 林良雄. Derivatization of amino group at 5-position of negamycin derivative for development of potent readthrough compound. 日本薬学会年会要旨集(Web). 2021. 141st

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Education (2)：

Professional career (1)：

Work history (2)：

2020/04 - 現在 Tokyo University of Pharmacy and Life Sciences School of Pharmacy Assistant Professor
2016/04 - 2020/03 University of California, San Diego Department of Chemistry and Biochemistry Postdoctoral Fellow

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