Hanada Yuki

ハナダユキ | Hanada Yuki

Affiliation and department：
Job title： Assistant professor
Homepage URL (1)： https://science.rikkyo.ac.jp/life-science/laboratory.html

Research field (2)： Cell biology , Metabolism and endocrinology

Research keywords (8)： Molecular cell biology at the surface of organelle membranes , Membrane protein , Mff , Energy sensing , Mitochondrial fission/fusion , Metabolism , Immune response , Mitochondria

Research theme for competitive and other funds (2)：

2023 - 2024 Regulatory mechanism of mitochondrial function on mitochondrial outer membrane, the interface with the host
2017 - 2018 Mitochondria-mediated metabolism-immune linkage for protection against viral infection

Papers (7)：

Yuki Hanada, Risa Maeda, Takaya Ishihara, Masaki Nakahashi, Yuichi Matsushima, Emi Ogasawara, Toshihiko Oka, Naotada Ishihara. Alternative splicing of Mff regulates AMPK-mediated phosphorylation, mitochondrial fission and antiviral response. Pharmacological Research. 2024. 209. 107414
Yukina Takeichi, Takashi Miyazawa, Shohei Sakamoto, Yuki Hanada, Lixiang Wang, Kazuhito Gotoh, Keiichiro Uchida, Shunsuke Katsuhara, Ryuichi Sakamoto, Takaya Ishihara, et al. Non-alcoholic fatty liver disease in mice with hepatocyte-specific deletion of mitochondrial fission factor. Diabetologia. 2021. 64. 9. 2092-2107
Lixiang Wang, Xin Li, Yuki Hanada, Nao Hasuzawa, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto. Dynamin-related protein 1 deficiency accelerates lipopolysaccharide-induced acute liver injury and inflammation in mice. Communications Biology. 2021. 4. 894
Yuki Hanada, Naotada Ishihara, Lixiang Wang, Hidenori Otera, Takaya Ishihara, Takumi Koshiba, Katsuyoshi Mihara, Yoshihiro Ogawa, Masatoshi Nomura. MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity. Nature Communications. 2020. 11. 1. 5711-5711
Seiichi Yano, Kenji Ashida, Hiromi Nagata, Kenji Ohe, Naoko Wada, Yukina Takeichi, Yuki Hanada, Yuta Ibayashi, Lixiang Wang, Shohei Sakamoto, et al. Nivolumab-induced thyroid dysfunction lacking antithyroid antibody is frequently evoked in Japanese patients with malignant melanoma. BMC Endocrine Disorders. 2018. 18. 36

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MISC (3)：

花田有希, 岡敏彦. 動物細胞からのミトコンドリア画分調製法とin vitro輸送アッセイ. 実験医学別冊疾患研究につながるオルガネラ実験必携プロトコール. 2024
Yuki Hanada, Takaya Ishihara, Naotada Ishihara. Molecular mechanism linking metabolism and innate immunity on mitochondria. Journal of Japanese Biochemical Society. 2022. 94. 2. 230-235
Yuki Hanada, Takaya Ishihara, Naotada Ishihara. Regulation of cellular functions by mitochondrial membrane dynamics. Seitai no Kagaku. 2018. 69. 6. 581-585

Lectures and oral presentations (10)：

Mitochondrial outer membrane proteins regulated by energy metabolism for signaling at the mitochondrial surface
(Cold Spring Harbor Asia Conference, Mitochondria and Metabolism in Health and Disease 2023)
エネルギー代謝と免疫応答を繋ぐミトコンドリアの新機能
(立教大学理学部生命理学科助教セミナー 2023)
Splicing-dependent functional regulation of mitochondrial fission factor Mff
(2022)
Two-sided control of antiviral response by mitochondrial immunometabolic factor
(The 44th Annual Meeting of the Molecular Biology Society of Japan 2021)
Molecular property of mitochondrial fission factor Mff for mitochondrial antiviral signaling
(2021)

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Education (3)：

2018 - 2020 Osaka University Graduate School of Science Department of Biological Sciences
2015 - 2020 Kyushu University Faculty of Medical Sciences
2009 - 2015 Kyushu University School of Pharmaceutical Sciences

Professional career (1)：

Doctor of Medical Science (Kyushu University)

Work history (2)：

2023/04 - 現在 Rikkyo University Department of Life Science Assistant professor
2019/04 - 2023/03 Osaka University Graduate School of Science Department of Biological Sciences Researcher

Awards (1)：

2018/09 - the 91st Annual Meeting of the Japanese Biochemical Society Young Scientist Award

Association Membership(s) (6)：

The Japanese Society of Mitochondrial Research and Medicine (J-mit) , The Molecular Biology Society of Japan , Japan Society for Cell Biology , The Japanese Biochemical Society , The Japan Endocrine Society , The Pharmaceutical Society of Japan

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