Rchr
J-GLOBAL ID：202001002532560518   Update date: Jun. 28, 2024

Kawaguchi Daichi

カワグチ ダイチ | Kawaguchi Daichi
Affiliation and department：
The University of Tokyo Graduate School of Pharmaceutical Sciences

About The University of Tokyo Graduate School of Pharmaceutical Sciences


Job title： Associate Professor
Research field  (2)： Neuroscience - general ,  Developmental biology
Research keywords  (5)： 脳・神経 ,  ニューロン ,  神経幹細胞 ,  大脳皮質 ,  神経発生
Research theme for competitive and other funds  (7)：
  • 2023 - 2025 生後のストレス脆弱「臨界期」を担うクロマチン制御と神経回路の解明
  • 2023 - 2025 発達期の局所脳形成異常に伴う社会行動の変容とその基盤となる広域脳動態の解明
  • 2021 - 2024 自閉症の病態理解に向けた神経幹細胞運命制御メカニズムの解明
  • 2018 - 2021 Mechanism of region-specific neocortical malformation relevant to autism spectrum disorder
  • 2016 - 2018 Molecular mechanisms of neocortical malformation relevant to autism spectrum disorder
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Papers (19)：
  • Shima Yamaguchi, Takaaki Kuniya, Hanae Omiya, Yutaka Suzuki, Masahide Seki, Hideki Ukai, Lingyan Fang, Yujin Harada, Daichi Kawaguchi, Yukiko Gotoh. Embryonic diversification of adult neural stem cells and ependymal cells. 2024
  • Lingyan Fang, Takaaki Kuniya, Yujin Harada, Osamu Yasuda, Nobuyo Maeda, Yutaka Suzuki, Daichi Kawaguchi, Yukiko Gotoh. TIMP3 promotes the maintenance of neural stem-progenitor cells in the mouse subventricular zone. Frontiers in neuroscience. 2023. 17. 1149603-1149603
  • Yujin Harada, Mayumi Yamada, Itaru Imayoshi, Ryoichiro Kageyama, Yutaka Suzuki, Takaaki Kuniya, Shohei Furutachi, Daichi Kawaguchi, Yukiko Gotoh. Cell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module. Nature communications. 2021. 12. 1. 6562-6562
  • Shun Utsunomiya, Yusuke Kishi, Masafumi Tsuboi, Daichi Kawaguchi, Yukiko Gotoh, Manabu Abe, Kenji Sakimura, Kazuma Maeda, Hiroshi Takemoto. Ezh1 regulates expression of Cpg15/Neuritin in mouse cortical neurons. Drug discoveries & therapeutics. 2021. 15. 2. 55-65
  • Naoya Yuizumi, Yujin Harada, Takaaki Kuniya, Takehiko Sunabori, Masato Koike, Masaki Wakabayashi, Yasushi Ishihama, Yutaka Suzuki, Daichi Kawaguchi, Yukiko Gotoh. Maintenance of neural stem-progenitor cells by the lysosomal biosynthesis regulators TFEB and TFE3 in the embryonic mouse telencephalon. Stem cells (Dayton, Ohio). 2021. 39. 7. 929-944
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MISC (6)：
  • 龍海 暢輝, 川口 大地. 神経幹細胞の増殖・分化過程の制御異常と自閉スペクトラム症の関連. 細胞. 2023. 55. 10. 828-831
  • 金 宥利, 川口 大地. 【環境の影響とその遺伝・DOHaD】環境が神経幹細胞および脳発達に与える影響と精神疾患との関連. 遺伝子医学. 2022. 12. 4. 48-54
  • 後藤 昂宏, 表 伯俊, 川口 大地. 【脳の半分を占めるグリア細胞 脳と心と体をつなぐ"膠"】(第1章)グリア細胞の分化・神経発達 神経系前駆細胞(放射状グリア)とアストロサイトの多様性. 実験医学. 2019. 37. 17. 2822-2827
  • 今泉 結, 川口 大地, 古舘 昌平, 後藤 由季子. 成体神経幹細胞の未分化性維持機構と発生起源について. 生化学. 2016. 88. 6. 766-770
  • 川口 大地, 古舘 昌平, 後藤 由季子. 成体神経幹細胞の枯渇を防ぐための幹細胞ストラテジー. 細胞工学. 2014. 33. 3. 310-315
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Education (2)：
  • - 2009 The University of Tokyo Graduate School of Frontier Sciences Department of Integrated Biosciences
  • - 2004 The University of Tokyo The Faculty of Engineering Department of Chemistry and Biotechnology
Professional career (1)：
  • 博士(生命科学) (東京大学)
Work history (7)：
  • 2022/07 - 現在 The University of Tokyo Graduate School of Pharmaceutical Sciences Associate Professor
  • 2016/01 - 2022/06 The University of Tokyo Graduate School of Pharmaceutical Sciences
  • 2014/04 - 2015/12 Japan Society for the Promotion of Science Overseas Research Fellow
  • 2011/01 - 2015/12 The Salk Institute Molecular Neurobiology Laboratory
  • 2010/04 - 2011/01 The University of Tokyo Institute of Molecular and Cellular Biosciences
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