Nishida Mikako

ニシダミカコ | Nishida Mikako

Affiliation and department：

Research field (1)： Immunology

Research keywords (1)：腫瘍免疫・代謝

Research theme for competitive and other funds (6)：

2024 - 2027 腫瘍血管内皮におけるNrf2-eNOS経路を介した新たな腫瘍血管正常化機構の解明
2021 - 2024 メトホルミンとファスティング併用による腫瘍微小環境改変に関する研究
2021 - 2024 IFNγによる腫瘍微小環境の代謝改変メカニズムの解明
2021 - 2022 新規糖代謝改善薬アスコクロリン誘導体によるがん免疫治療薬の開発
2019 - 2021 Molecular mechanism underlying the metabolic reprogramming of tumor microenvironment by the combination therapy of metformin and anti-PD-1 antibody

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Papers (10)：

Satoshi Akagi, Kazufumi Nakamura, Megumi Kondo, Satoshi Hirohata, Heiichiro Udono, Mikako Nishida, Yukihiro Saito, Masashi Yoshida, Toru Miyoshi, Hiroshi Ito. Evidence for Hypoxia-Induced Shift in ATP Production from Glycolysis to Mitochondrial Respiration in Pulmonary Artery Smooth Muscle Cells in Pulmonary Arterial Hypertension. Journal of clinical medicine. 2023. 12. 15
Yoichiro Harada, Yu Mizote, Takehiro Suzuki, Akiyoshi Hirayama, Satsuki Ikeda, Mikako Nishida, Toru Hiratsuka, Ayaka Ueda, Yusuke Imagawa, Kento Maeda, et al. Metabolic clogging of mannose triggers dNTP loss and genomic instability in human cancer cells. eLife. 2023. 12
Heiichiro Udono, Mikako Nishida. Metformin-ROS-Nrf2 connection in the host defense mechanism against oxidative stress, apoptosis, cancers, and ageing. Biochimica et Biophysica Acta (BBA) - General Subjects. 2022. 1866. 8. 130171-130171
Miho Tokumasu, Mikako Nishida, Takamasa Kawaguchi, Ikuru Kudo, Tohru Kotani, Kazuhiko Takeda, Takao Yoshida, Heiichiro Udono. Blocking EP4 downregulates tumor metabolism and synergizes with anti-PD-1 therapy to activate natural killer cells in a lung adenocarcinoma model. International immunology. 2022
Ruoyu Chao, Mikako Nishida, Nahoko Yamashita, Miho Tokumasu, Weiyang Zhao, Ikuru Kudo, Heiichiro Udono. Nutrient Condition in the Microenvironment Determines Essential Metabolisms of CD8+ T Cells for Enhanced IFNγ Production by Metformin. Frontiers in immunology. 2022. 13. 864225-864225

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MISC (32)：

鵜殿平一郎, CHAO Ruoyu, 徳増美穂, 西田充香子. 代謝 IV.代謝と免疫代謝介入による抗腫瘍免疫の変化. 生体の科学. 2023. 74. 5
西田充香子, CHAO Ryoyu, 鵜殿平一郎. Cytotoxic T cell activation mechanism via metabolic reprogramming by metformin. 月刊臨床免疫・アレルギー科. 2023. 80. 2
西田充香子, 鵜殿平一郎. 腫瘍細胞とエフェクターT細胞の代謝競合改善を介した腫瘍免疫の向上. 先進医療NAVIGATOR がん免疫療法最前線. 2023. 34-36
鵜殿平一郎, 工藤生, 西田充香子. IFNγを介したCD8TILと腫瘍血管のクロストーク促進、及び腫瘍微小環境の代謝改変. 日本がん免疫学会総会プログラム・抄録集. 2023. 27回. 58-58
西田充香子, 鵜殿平一郎. 代謝介入による抗腫瘍免疫応答の向上(Metabolic intervention facilitates anti-tumor immunity). 日本癌学会総会記事. 2022. 81回. S5-3

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Patents (2)：

Education (1)：

Okayama University Graduate School of Medicine , Dentistry and Pharmaceutical Sciences

Professional career (1)：

Work history (3)：

Awards (7)：

2023/12 - Japanese Society of Immunology International Immunology Outstanding Merit Award Outstanding Merit Award 2023, “Blocking EP4 down-regulates tumor metabolism and synergizes with anti-PD-1 therapy to activate natural killer cells in a lung adenocarcinoma model, 日本免疫学会 “Blocking EP4 down-regulates tumor metabolism and synergizes with anti-PD-1 therapy to activate natural killer cells in a lung adenocarcinoma model
2022/10 - 第44回公益財団法人両備檉園記念財団・生物学研究奨励賞
2022/06 - 岡山医学会賞がん研究奨励賞(林原賞・山田賞)
2018/08 - 第22回日本がん免疫学会総会若手研究奨励賞
2018/06 - 第45回内藤コンファレンス優秀ポスター賞

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Association Membership(s) (4)：

日本がん免疫学会 , 日本免疫学会 , 日本癌学会 , 日本臨床ストレス応答学会

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