Rchr
J-GLOBAL ID：202001002901113717
Update date: Aug. 28, 2024
Higurashi Masato
ヒグラシ マサト | Higurashi Masato
Affiliation and department：
Job title：
助教
Research field (3)：
Cell biology
, Tumor biology
, Molecular biology
Research keywords (3)：
ミトコンドリア
, 呼吸鎖複合体
, サーチュイン
Research theme for competitive and other funds (3)：
- 2022 - 2025 転移抑制を目指したRac1によるintegrin β4の分解抑制機構の解明
- 2021 - 2025 Respiratory chain activity as a target of tumor-agnostic therapy in highly glycolytic/low respiratory tumors
- 2022 - 2024 呼吸鎖複合体Iによるヒストン修飾制御を介した癌増殖メカニズムの解明と臨床的意義
Papers (5)：
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Hidetsugu Nakagawa, Masato Higurashi, Fumihiro Ishikawa, Kazunori Mori, Motoko Shibanuma. An indispensable role of TAZ in anoikis resistance promoted by OTUB1 deubiquitinating enzyme in basal-like triple-negative breast cancer cells. Biochemical and biophysical research communications. 2023. 649. 1-9
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Tsuyoshi Maruyama, Koji Saito, Masato Higurashi, Fumihiro Ishikawa, Yohko Kohno, Kazunori Mori, Motoko Shibanuma. HMGA2 drives the IGFBP1/AKT pathway to counteract the increase in P27KIP1 protein levels in mtDNA/RNA-less cancer cells. Cancer Science. 2022. 114. 1. 152-163
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Kazunori Mori, Masato Higurashi, Fumihiro Ishikawa, Motoko Shibanuma. Rac1-mediated sustained β4 integrin level develops reattachment ability of breast cancer cells after anchorage loss. Cancer science. 2021. 112. 8. 3205-3217
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Masato Higurashi, Tsuyoshi Maruyama, Yusuke Nogami, Fumihiro Ishikawa, Yukiko Yoshida, Kazunori Mori, Ken-Ichi Fujita, Motoko Shibanuma. High expression of FOXM1 critical for sustaining cell proliferation in mitochondrial DNA-less liver cancer cells. Experimental cell research. 2020. 389. 1. 111889-111889
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Kazunori Mori, Tetsu Uchida, Motonori Fukumura, Shigetoshi Tamiya, Masato Higurashi, Hirosato Sakai, Fumihiro Ishikawa, Motoko Shibanuma. Linkage of E2F1 transcriptional network and cell proliferation with respiratory chain activity in breast cancer cells. Cancer science. 2016. 107. 7. 963-71
Lectures and oral presentations (19)：
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A role of NAD<sup>+</sup>-SIRT3/6 axes in control of p21<sup>Cip1</sup> expression and cancer cell proliferation.
(2023)
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Stabilization of the oncogene TAZ by the deubiquitinating enzyme OTUB1 contributes to anchorage-independent cell survival in breast cancer cells
(日本薬学会年会要旨集(Web) 2023)
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HMGA2 drives IGFBP1/AKT pathway to counteract the increase in P27KIP1 protein in mitochondria-deficient cancer cells
(2022)
-
High expression of FOXM1 critical for sustaining cell proliferation in mitochondrial DNA-less liver cancer cells
(2022)
-
Epigenetic control of p21<sup>Cip1</sup> expression and cell proliferation by respiratory chain complex I via NAD<sup>+</sup> supply
(2021)
ｍore...
Education (2)：
- 2016 - 2020 Showa University Pharmaceutical Scientific Research Division
- 2010 - 2016 Showa University School of Pharmacy
Professional career (1)：
Work history (1)：
- 2020/04 - 現在 昭和大学 薬学部 基礎薬学講座 腫瘍細胞生物学部門 助教
Awards (2)：
- 2022/07 - The Japanese Tissue Culture Association Young Investigator Award at the 94th Annual Meeting of Japanese Tissue Culture Association
- 2020/03 - 昭和大学 上條賞(大学院 薬学研究科 )
Association Membership(s) (3)：
The Japanese Tissue Culture Association
, 日本分子生物学会
, 日本癌学会
