Tomokiyo Atsushi

トモキヨアツシ | Tomokiyo Atsushi

Affiliation and department：

Research field (5)： Regenerative dentistry and dental engineering , Regenerative dentistry and dental engineering , Conservative dentistry and endodontics , Conservative dentistry and endodontics , Biomaterials

Research keywords (5)：歯科保存学 , 組織再生 , 幹細胞 , バイオミメティクス , 歯内療法

Research theme for competitive and other funds (22)：

2024 - 2027 Utilizing a double-network self-healing hydrogel in resin composite restorations
2022 - 2026 To elucidate the mechanism of senescence of dentin-pulp complex targeting the oxidative stress.
2022 - 2025 歯周組織発生過程の模倣を基盤とするハイブリッド構造体の創成と歯周組織再生への応用
2021 - 2024 根面う蝕を標的としたファージ療法の創出
2019 - 2023 オミックス解析を用いた歯根膜発生機構の解明と幹細胞誘導型組織再生技術への応用

2021 - 2023 食品を介したダイオキシン類等の人体への影響の把握とその治療法の開発等に関する研究

2021 - 2023 Development of a new drug for periodontal regeneration based on the activation of neural crest cells

2017 - 2022 Establishment of the the method to develop 3D-periodontal ligament from iPS cells, and its application for artificial tooth root

2018 - 2021 Generation of a compound that has the potential to induce the formation of PDLSCs using iPS- and genome-based drug discovery technology.

2017 - 2021 Development of the new periodontal ligament regeneration method based on iPS-derived neural crest cells

2016 - 2019 Development of a simulation system for endodontic treatment using 3D printer

2015 - 2019 The study of tissue engineering utilizing periodontal ligament stem cell induced by tropic factors

2014 - 2017 Development of the dentin-repairing therapy regulating the calcium-sensing receptor

2013 - 2017 Development of bioactive resin containing the capacity to induce periodontal tissue formation

2014 - 2016 新規覆髄材の開発を目的としたBig-h3の解析

2012 - 2013 歯根膜幹細胞由来神経再生因子を用いた新規の末梢神経ならびに歯根膜組織再生法の開発

2011 - 2012 Development of successful intentional replantation

2010 - 2012 Development of next-generation artificial tooth root including periodontal ligament

2010 - 2012 Development of novel periodontal tissue therapy targeting for regeneration of periodontal ligament.

2009 - 2011 What is required for periodontal ligament regeneration?

2009 - 2010 The application of periodontal ligament stem cells for the injured neural tissues

2007 - 2009 Clarification of the mechanisms of regeneration of periodontal ligament using human clonal periodontal ligament progenitor cell line

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Papers (74)：

Md Refat Readul Islam, Rafiqul Islam, Yunqing Liu, Yu Toida, Yasuhiro Yoshida, Hidehiko Sano, Hany Mohamed Aly Ahmed, Atsushi Tomokiyo. Biological evaluation of novel phosphorylated pullulan-based calcium hydroxide formulations as direct pulp capping materials: An in vivo study on a rat model. International endodontic journal. 2024. 57. 9. 1247-1263
Hideki Sugii, Shinichiro Yoshida, Mhd Safwan Albougha, Sayuri Hamano, Daigaku Hasegawa, Tomohiro Itoyama, Junko Obata, Hiroshi Kaneko, Fumiko Minowa, Atsushi Tomokiyo, et al. 4-META/MMA-TBB resin containing nano hydroxyapatite induces the healing of periodontal tissue repair in perforations at the pulp chamber floor. Cell biochemistry and function. 2024. 42. 4. e4058
友清淳, 戸井田侑, 槌谷賢太, 矢後亮太朗, 金澤凪沙, 川本千春. 硬化後のWhite Mineral Trioxide Aggregateに対するウォーキングブリーチ用薬剤の影響. 日本歯内療法学会雑誌. 2024. 45. 2. 112-121
Yitong Li, Masahiko Maeno, Carolina Cecilia Cifuentes-Jimenez, Mei Komoto, Yunqing Liu, Yoichiro Nara, Hidehiko Sano, Pedro Alvarez-Lloret, Monica Yamauti, Atsushi Tomokiyo. Effect of Simulated Dental Pulpal Pressure Using Fetal Bovine Serum for the Bonding Performance of Contemporary Adhesive to Dentin. Polymers. 2024. 16. 9
Papichaya Intajak, Yuan Yuan, Norihito Sakaguchi, Pipop Saikaew, Pimpinee Eamsaard, Mariko Matsumoto, Hidehiko Sano, Atsushi Tomokiyo. Effect of Silver Diamine Fluoride on Bonding Performance and Ultra-morphological Characteristics to Sound Dentin. Dental materials : official publication of the Academy of Dental Materials. 2024. 40. 4. e24-e32

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MISC (104)：

川本千春, 矢後亮太朗, 福山麻衣, 友清淳. 誤嚥防止ロール状ガーゼの開発-誤嚥防止能力の評価-. 日本医用歯科機器学会誌. 2024. 29. 2
戸井田侑, ISLAM MD Refat Readul, QIBUER, YUAN Yuan, 福山麻衣, 池田考績, 星加修平, 佐野英彦, 友清淳. Evaluation of mechanical properties of resin cements and a composite resin with different curing systems. 日本歯科保存学会学術大会プログラムおよび講演抄録集(Web). 2024. 160th
友清淳, 戸井田侑, ISLAM Md Refat Readul, ヤマウチモニカ, 星加修平, 川本千春, ISLAM Rafiqul, 福山麻衣. Effects of a walking bleach agent on White Mineral Trioxide Aggregate. 日本歯科保存学会学術大会プログラムおよび講演抄録集(Web). 2024. 160th
槌谷賢太, 槌谷賢太, 佐野英彦, YAMAUTI Monica, 星加修平, 戸井田侑, 福山麻衣, 友清淳. Physical-Chemical characterization of “Multicolor” CAD/CAM Materials. 日本歯科保存学会学術大会プログラムおよび講演抄録集(Web). 2024. 160th
山下大輝, 友清淳, 濱野さゆり, 濱野さゆり, 前田英史, 前田英史. Application of heat-treated nickel-titanium files and new reciprocating motion in Tri Auto ZX2 for the development of apical patency. 日本歯内療法学会雑誌. 2024. 45. 1. 34-40

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Books (7)：

Detection, Characterization, and Clinical Application of Mesenchymal Stem Cells in Periodontal Ligament Tissue: Advanced Study.
Book Publisher International. 2020
日本歯科評論
HYORON 2018
エンドドンティックス第五版
永末書店 2018
保存修復学21第五版
永末書店 2017
Contribution of Stem Cells to Dental Tissue Regeneration: Isolation, Function, and Application.
Bentham Science Publishers 2015

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Lectures and oral presentations (91)：

フェノール系貼薬剤はケイ酸カルシウムの体積増加を介して硬化後のWhite Mineral Trioxide Aggregateの崩壊を誘導し封鎖性を低下させる
(第157回日本歯科保存学会 2022)
バイオミメティクスを基盤とした歯周組織再生療法,直接覆髄剤,およびバイオハイブリッドインプラント創出の試み.
(第155回日本歯科保存学会 2021)
WMTAの組成成分に及ぼすフェノール系貼薬剤の影響について.
(第24回日本歯科医学会学術大会. 2021)
Aryl hydrocarbon receptorの活性化がヒト歯根膜細胞のMMP2およびMMP12発現に及ぼす影響
(令和3年度全国油症治療研究班会議 2021)
secreted Frizzled-Related Protein 1 promotes odontoblastic differentiation and reparative dentin formation by regulating Notch signaling in dental pulp cells
(Kyudai Oral Bioscience & OBT Research Center Joint International Symposium 2021 2021)

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Education (2)：

2004 - 2008 九州大学大学院歯内疾患制御学研究分野
1998 - 2004 Kyushu University School of Dentistry

Professional career (1)：

Ph.D. (Kyushu University)

Work history (9)：

2023/04 - 現在北海道大学大学院歯学研究院口腔健康科学分野歯科保存学教室教授
2022/04 - 現在九州大学大学院歯学研究院Dent-craniofacial Development and Regeneration (DDR) センター兼務
2022/06 - 2023/03 九州大学病院歯内治療科診療准教授
2016/12 - 2022/05 九州大学病院歯内治療科講師
2014/09 - 2016/11 九州大学病院歯内治療科助教

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Awards (12)：

2018/06 - 日本歯科保存学会日本歯科保存学会学術賞
2016/07 - 日本歯内療法学会 JEA会長賞
2015/10 - 日本歯科保存学会日本歯科保存学会ジーシー優秀ポスター賞
2014/10 - 日本歯科保存学会日本歯科保存学会ジーシー優秀ポスター賞
2012/06 - 日本歯内療法学会平成24年度日本歯内療法学会優秀論文賞

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Association Membership(s) (9)：

象牙質歯髄治療学会 , 日本歯科医学教育学会 , 日本スポーツ歯科医学会 , International Association of Dental Research , Japan Asssociation of Dental Research , Japanese society for regenerative medicine , Japanese Society of Gerodontology , 日本歯内療法学会. , 日本歯科保存学会

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