Kagoya Yuki

カゴヤユウキ | Kagoya Yuki

Affiliation and department：
Job title： Professor

Research field (1)： Immunology

Research theme for competitive and other funds (7)：

2023 - 2026 Development of CAR-NK cell therapy with durable response through genetic manipulation
2022 - 2025 The determination of T-cell fate by different tumor antigens and prevention of post-operative recurrence of lung cancer
2022 - 2025 The determination of T-cell fate by different tumor antigens and prevention of post-operative recurrence of lung cancer
2021 - 2023 Development of a combinatorial approach of antibody therapeutics and adoptive immunotherapy for cancer
2020 - 2023 Generation of long-surviving antitumor T cells by genetic modification for optimal adoptive immunotherapy

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Papers (49)：

Toshiaki Yoshikawa, Yusuke Ito, Zhiwen Wu, Hitomi Kasuya, Takahiro Nakashima, Sachiko Okamoto, Yasunori Amaishi, Haosong Zhang, Yang Li, Tetsuya Matsukawa, et al. Development of a chimeric cytokine receptor that captures IL-6 and enhances the antitumor response of CAR-T cells. Cell Reports Medicine. 2024. 5. 5. 101526-101526
Nakashima T, Kagoya Y. Current progress of CAR-T-cell therapy for patients with multiple myeloma. Int J Hematol. 2024
Hitomi Kasuya, Haosong Zhang, Yusuke Ito, Toshiaki Yoshikawa, Takahiro Nakashima, Yang Li, Tetsuya Matsukawa, Satoshi Inoue, Yuki Kagoya. High CD62L expression predicts the generation of chimeric antigen receptor T cells with potent effector functions. International Immunology. 2024. 36. 7. 353-364
Yuki Kagoya. Cytokine signaling in chimeric antigen receptor T-cell therapy. International Immunology. 2024. 36. 2. 49-56
Toshiya Hino, Fumio Nakahara, Masashi Miyauchi, Yusuke Ito, Yosuke Masamoto, Ken Morita, Yuki Kagoya, Hirotatsu Kojima, Mineo Kurokawa. AKT2 inhibition accelerates the acquisition of phagocytic ability in induced pluripotent stem cell-derived neutrophils. Experimental hematology. 2024. 130. 104137-104137

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MISC (9)：

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Lectures and oral presentations (48)：

CAR-T細胞の前臨床評価におけるヒト化マウスの活用
(2024)
Regulation of cytokine signaling for improved adoptive immunotherapy
(The 42nd Sapporo International Cancer Symposium 2024)
Reinforcing CAR-T cell function through metabolic regulation
(2024)
Adoptive immunotherapy for autoimmune diseases
(2024)
Understanding the mechanisms of resistance to CAR-T cell therapy at the molecular level
(The 1st International Symposium on Cancer Immunology and Immunotherapy 2024)

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Education (2)：

Professional career (1)：

Work history (8)：

2023/01 - 現在 Keio University School of Medicine Division of Tumor Immunology, Institute for Advanced Medical Research Professor
2020/04 - 2022/12 Nagoya University Graduate School of Medicine Division of Cellular Oncology, Department of Cancer Diagnostics and Therapeutics Adjunct Professor
2019/10 - 2022/12 Aichi Cancer Center, Research Institute Division of Immune Response Chief
2018/06 - 2019/09 The University of Tokyo Faculty of Medicine University Hospital Assistant Professor
2014/06 - 2018/05 Princess Margaret Cancer Centre Tumor Immunotherapy Program Research Fellow

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