Rchr
J-GLOBAL ID:202001004324257553
Update date: Jul. 19, 2024
Kagoya Yuki
カゴヤ ユウキ | Kagoya Yuki
Affiliation and department:
Job title:
Professor
Research field (1):
Immunology
Research theme for competitive and other funds (6):
- 2023 - 2026 Development of CAR-NK cell therapy with durable response through genetic manipulation
- 2022 - 2025 The determination of T-cell fate by different tumor antigens and prevention of post-operative recurrence of lung cancer
- 2021 - 2023 Development of a combinatorial approach of antibody therapeutics and adoptive immunotherapy for cancer
- 2020 - 2023 Generation of long-surviving antitumor T cells by genetic modification for optimal adoptive immunotherapy
- 2019 - 2021 Development of a chimeric synthetic receptor to suppress T cell exhaustion for use in adoptive cancer immunotherapy
- 2013 - 2015 Elucidation of the mechanism of transformation of myeloproliferative neoplasm into acute myelogenous leukemia for novel therapeutic strategy for the disease.
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Papers (48):
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Toshiaki Yoshikawa, Yusuke Ito, Zhiwen Wu, Hitomi Kasuya, Takahiro Nakashima, Sachiko Okamoto, Yasunori Amaishi, Haosong Zhang, Yang Li, Tetsuya Matsukawa, et al. Development of a chimeric cytokine receptor that captures IL-6 and enhances the antitumor response of CAR-T cells. Cell Reports Medicine. 2024. 5. 5. 101526-101526
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Nakashima T, Kagoya Y. Current progress of CAR-T-cell therapy for patients with multiple myeloma. Int J Hematol. 2024
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Hitomi Kasuya, Haosong Zhang, Yusuke Ito, Toshiaki Yoshikawa, Takahiro Nakashima, Yang Li, Tetsuya Matsukawa, Satoshi Inoue, Yuki Kagoya. High CD62L expression predicts the generation of chimeric antigen receptor T cells with potent effector functions. International Immunology. 2024. 36. 7. 353-364
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Yuki Kagoya. Cytokine signaling in chimeric antigen receptor T-cell therapy. International Immunology. 2024. 36. 2. 49-56
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Yusuke Ito, Satoshi Inoue, Takahiro Nakashima, Haosong Zhang, Yang Li, Hitomi Kasuya, Tetsuya Matsukawa, Zhiwen Wu, Toshiaki Yoshikawa, Mirei Kataoka, et al. Epigenetic profiles guide improved CRISPR/Cas9-mediated gene knockout in human T cells. Nucleic Acids Research. 2024. 52. 1. 141-153
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MISC (9):
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籠谷 勇紀. CAR-T細胞療法開発の現状と今後の展望. 血液内科(科学評論社). 2024. 88. 2. 176-182
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籠谷 勇紀. 血液がんを標的としたCAR-T細胞療法の現状と課題. 炎症と免疫(先端医学社). 2023. 31. 4. 283-288
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籠谷 勇紀. 多発性骨髄腫に対するCAR-T細胞療法の研究開発動向. 血液内科(科学評論社). 2023. 86. 5. 676-681
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籠谷 勇紀. キメラ抗原受容体遺伝子改変T細胞療法の改良. 腫瘍内科(科学評論社). 2023. 31. 4. 462-467
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籠谷 勇紀. PRDM1遺伝子ノックアウトによる長期生存型抗腫瘍T細胞の作製. 血液内科(科学評論社). 2022. 85. 5. 753-758
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Lectures and oral presentations (48):
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CAR-T細胞の前臨床評価における ヒト化マウスの活用
(2024)
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Regulation of cytokine signaling for improved adoptive immunotherapy
(The 42nd Sapporo International Cancer Symposium 2024)
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Reinforcing CAR-T cell function through metabolic regulation
(2024)
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Adoptive immunotherapy for autoimmune diseases
(2024)
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Understanding the mechanisms of resistance to CAR-T cell therapy at the molecular level
(The 1st International Symposium on Cancer Immunology and Immunotherapy 2024)
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Education (2):
- 2009 - 2013 The University of Tokyo Graduate School of Medicine
- 2001 - 2007 The University of Tokyo Faculty of Medicine
Professional career (1):
Work history (8):
- 2023/01 - 現在 Keio University School of Medicine Division of Tumor Immunology, Institute for Advanced Medical Research Professor
- 2020/04 - 2022/12 Nagoya University Graduate School of Medicine Division of Cellular Oncology, Department of Cancer Diagnostics and Therapeutics Adjunct Professor
- 2019/10 - 2022/12 Aichi Cancer Center, Research Institute Division of Immune Response Chief
- 2018/06 - 2019/09 The University of Tokyo Faculty of Medicine University Hospital Assistant Professor
- 2014/06 - 2018/05 Princess Margaret Cancer Centre Tumor Immunotherapy Program Research Fellow
- 2013/10 - 2014/05 The University of Tokyo Faculty of Medicine University Hospital Heamatology and Oncology Assistant Professor
- 2013/04 - 2013/09 The University of Tokyo Faculty of Medicine University Hospital Heamatology and Oncology Research Fellow
- 2007/04 - 2009/03 Kanto Rosai Hospital
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