Kyogoku Hirohisa

キョウゴクヒロヒサ | Kyogoku Hirohisa

Affiliation and department：
Other affiliations (2)：

Homepage URL (1)： https://sites.google.com/view/kyogoku-lab/%E3%83%9B%E3%83%BC%E3%83%A0?authuser=0

Research field (1)： Developmental biology

Research theme for competitive and other funds (9)：

2024 - 2026 Deciphering the design principles of the genome through the analysis of its potential instability
2022 - 2024 Elucidation of the mechanism by which zygotes recovers from abnormal chromosome segregation to maintain totipotency
2020 - 2024 顕微操作技術による初期胚の不安定なゲノムの分配システムの解明
2020 - 2022 Elucidation of totipotency acquisition mechanism controlled by nuclear size
2019 - 2021 Elucidation of the cause of changes in the frequency of chromosome segregation error during early embryonic development

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Papers (22)：

Hirohisa Kyogoku. Chromosome aberrations in early embryos. JOURNAL OF MAMMALIAN OVA RESERCH. 2025
Mihoko Fushii, Hirohisa Kyogoku, Jibak Lee, Takashi Miyano. Change in the ability of bovine granulosa cells to elongate transzonal projections and their transcriptome changes during follicle development. The Journal of reproduction and development. 2024
Saori Takahashi, Hirohisa Kyogoku, Takuya Hayakawa, Hisashi Miura, Asami Oji, Yoshiko Kondo, Shin-Ichiro Takebayashi, Tomoya S Kitajima, Ichiro Hiratani. Embryonic genome instability upon DNA replication timing program emergence. Nature. 2024
Hirohisa Kyogoku, Tomoya S Kitajima. The large cytoplasmic volume of oocyte. The Journal of reproduction and development. 2022
Narumi Ogonuki, Hirohisa Kyogoku, Toshiaki Hino, Yuki Osawa, Yasuhiro Fujiwara, Kimiko Inoue, Tetsuo Kunieda, Seiya Mizuno, Hiroyuki Tateno, Fumihiro Sugiyama, et al. Birth of mice from meiotically arrested spermatocytes following biparental meiosis in halved oocytes. EMBO reports. 2022. e54992

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MISC (37)：

京極博久. 受精卵における雌雄前核間の細胞質競合による発生制御 1PN胚はなぜ発生能が低いのか?. Journal of Clinical Embryologist. 2023. 25. 219-219
京極博久, 多羅間充輔, 中川れい子, 柴田達夫, 北島智也. 核と細胞質を繋ぐ核膜孔と様々な生命現象受精卵における核膜孔を介した雌雄前核間の細胞質競合. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [3S04m-03]
京極博久, 多羅間充輔, 三品達平, 原田哲仁, 中川れい子, 大川恭行, 柴田達夫, 北島智也. Cytoplasmic competition between separate parental pronuclei in zygotes. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
原山洋, 原山洋, 植芝愛巳, 森川莉帆, 京極博久. ブタ射出精子での体外受精能力発現に及ぼすcAMPシグナリング活性化処理の影響. 日本アンドロロジー学会総会記事. 2023. 42nd
伏井実穂子, 京極博久, LEE Jibak. Differentiation of bovine granulosa cells and changes in their ability to support oocyte growth. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th

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Lectures and oral presentations (24)：

The source of chromosome abnormalities in early embryos
(EMBO Workshop on Molecular mechanisms of developmental and regenerative biology 2024)
顕微操作技術による初期胚の不安定なゲノムの分配システムの解明
(CREST「ゲノム合成」2024年度領域会議 2024)
Analysis of unstable chromosome segregation system in early embryonic development with micromanipulation approach
(2024)
初期胚の染色体分配異常発生メカニズム
(第65回日本卵子学会学術集会 2024)
受精卵における雌雄前核間の細胞質競合による発生制御 ~1PN胚はなぜ発生能が低いのか?~
(第29回日本臨床エンブリオロジスト学会学術大会 2024)

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Work history (3)：

2020/11 - 現在 Japan Science and Technology Agency
2020/11 - 現在 Kobe University Graduate School of Agricultural Science Department of Bioresource Science
2020/11 - 現在 RIKEN BDR

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