Nakazawa Yuka

ナカザワユカ | Nakazawa Yuka

Affiliation and department：
Homepage URL (1)： http://www.riem.nagoya-u.ac.jp/4/genetics/index.html

Research field (5)： Molecular biology , Medical biochemistry , Pathobiochemistry , Environmental effects of radiation , Environmental effects of chemicals

Research keywords (16)：転写共役修復 , ゲノム不安定性 , 難治性疾患 , 遺伝性疾患 , ゲノム医化学 , 分子細胞生物学 , ゲノム生物学 , 人類遺伝学 , DNA修復 , 転写と共役したヌクレオチド除去修復 , ヌクレオチド除去修復 , 次世代ゲノム解析 , マルチオミクス解析 , VUS , ブロックオリゴ , 核酸創薬

Research theme for competitive and other funds (14)：

2023 - 2030 転写共役DNA修復の分子機構と老化関連疾患の分子病態解明
2024 - 2027 コケイン症候群とその類縁疾患の分子病態解明・治療法開発
2024 - 2027 色素性乾皮症の新規責任遺伝子XPJによるDNA修復と転写制御機構の解明
2020 - 2024 チェルノブイリ放射線誘発甲状腺がんの遺伝子バンク設立と分子遺伝疫学国際共同研究
2021 - 2024 転写共役修復 (TCR)の分子メカニズム解明とTCR欠損ヒト遺伝性疾患の分子病態

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Papers (43)：

Paula J. van der Meer, George Yakoub, Yuka Nakazawa, Tomoo Ogi, Martijn Luijsterburg. Clearance of DNA damage-arrested RNAPII is selectively impaired in Cockayne syndrome cells. 2024
Yasuyoshi Oka, Yuka Nakazawa, Mayuko Shimada, Tomoo Ogi. Endogenous aldehyde-induced DNA-protein crosslinks are resolved by transcription-coupled repair. Nature Cell Biology. 2024
Akiko Tomita, Hiroyuki Sasanuma, Tomoo Owa, Yuka Nakazawa, Mayuko Shimada, Takahiro Fukuoka, Tomoo Ogi, Shinichiro Nakada. Inducing multiple nicks promotes interhomolog homologous recombination to correct heterozygous mutations in somatic cells. Nature communications. 2023. 14. 1. 5607-5607
Chikako Senju*, Yuka Nakazawa*, Taichi Oso*, Mayuko Shimada, Kana Kato, Michiko Matsuse, Mariko Tsujimoto, Taro Masaki, Yasushi Miyazaki, Satoshi Fukushima, et al. Deep intronic founder mutations identified in the ERCC4/XPF gene are potential therapeutic targets for a high-frequency form of xeroderma pigmentosum. PNAS (Proceedings of the National Academy of Sciences of the United States of America). 2023. 120. 27. e2217423120
Tsujimoto M, Nakano E, Nakazawa Y, Kanda F, Ueda T, Ogi T, Nishigori C. A case of Cockayne syndrome with unusually mild clinical manifestations. Journal of Dermatology. 2023. 50. 4. 541-545

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MISC (10)：

鍬塚大, 岩永聰, 宇谷厚志, 室田浩之, 富村沙織, 郡家佑美, 中沢由華, 荻朋男. 長崎大学病院皮膚科・アレルギー科を受診した色素性乾皮症患者の解析と考察. 西日本皮膚科. 2022. 84. 6. 574-574
Yasukazu Daigaku, Thomas Etheridge, Yuka Nakazawa, Tomoo Ogi, Antony Carr. Maintenance of unperturbed DNA replication by ubiquitylation of the replication sliding clamp. GENES & GENETIC SYSTEMS. 2016. 91. 6. 324-324
土肥良一郎, 土谷智史, 畑地豪, 西村智, 松山睦美, 中沢由華, 山崎直哉, 松本桂太郎, 宮崎拓郎, 扇玉秀順, et al. ラット脱細胞化肺における肺血管作製. 移植. 2016. 51. 2-3. 258-258
N. Jia, Y. Nakazawa, C. Guo, M. Shimada, M. Sethi, Y. Takahashi, H. Ueda, Y. Nagayama, T. Ogi. Click-iT DNA damage and repair assay. Assay and Drug Development Technologies. 2015. 13. 186-187
Nakazawa Yuka, Ogi Tomoo, Guo Chaowan, Shimada Mayuko, Jia Nan. P-011 XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency(Poster Sessions). 2015. 44. 98-98

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Patents (3)：

色素性乾皮症F群治療薬
日焼けの原因遺伝子
損傷DNA修復物質のスクリーニング方法

Books (2)：

Molecular cloning and characterisation of UVSSA, the responsible gene for UV-sensitive syndrome.
Seikagaku 2013
「紫外線高感受性症候群.」, 別冊日本臨床新領域別症候群シリーズ No.19 先天代謝異常症候群(第2版)(上)
日本臨床社 2012

Lectures and oral presentations (5)：

転写共役修復機構の分子メカニズムとその破綻による生体影響の解明
(第45回分子生物学会年会 2022)
Coordinated ubiquitination of RPB1-K1268 and UVSSA-K414 promotes transcription-coupled nucleotide excision repair
(日本放射線影響学会第64回大会 2021)
Alterations in the RNA polymerase IIo ubiquitination cause TC-NER defect and Cockayne syndrome-like premature aging phenotype in mice
(International Symposium on XP and other Nucleotide Excision Repair Disorders 2019)
ゲノム不安定性を示す遺伝性疾患の分子病態.
(第3回名大医薬系3部局交流シンポジウム〜岐阜薬科大学・岐阜大学G-CHAIN・ラクオリア創薬合同シンポジウム〜 2018)
Characterization of new pathogenic mutations associated with radiation sensitivity and developmental abnormalities.
(2014)

Professional career (1)：

博士 (医学) (長崎大学)

Work history (2)：

2021/05 - 現在名古屋大学環境医学研究所生体適応・防御研究部門発生・遺伝分野講師
2018/03 - 2021/04 Department of Genetics, Research Institute of Environmental Medicine (RIEM), Nagoya University

Awards (1)：

2016 - 第39回日本分子生物学会年会優秀ポスター賞ゲノム不安定性を示す遺伝性疾患群の病態解析と新規疾患責任遺伝子変異探索

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