Shiraishi Yutaro

シライシユウタロウ | Shiraishi Yutaro

Research theme for competitive and other funds (3)：

2024 - 2027 SARS-CoV-2の自然免疫回避を担うパパイン様プロテアーゼ基質選択性の構造基盤
2022 - 2024 Elucidation of the GPCR-mediated activation mechanism of arrestin by using NMR
2015 - 2017 Gタンパク質共役型受容体のGRK/アレスチンを介したシグナル伝達制御機構の解明

Papers (13)：

Yutaro Shiraishi, Ichio Shimada. NMR Characterization of the Papain-like Protease from SARS-CoV-2 Identifies the Conformational Heterogeneity in Its Inhibitor-Binding Site. Journal of the American Chemical Society. 2023
Yutaro Shiraishi, Yutaka Kofuku, Takumi Ueda, Shubhi Pandey, Hemlata Dwivedi-Agnihotri, Arun K. Shukla, Ichio Shimada. Biphasic activation of β-arrestin 1 upon interaction with a GPCR revealed by methyl-TROSY NMR. Nature Communications. 2021. 12. 1. 7158-7158
Koh Takeuchi, Yutaka Kofuku, Shunsuke Imai, Takumi Ueda, Yuji Tokunaga, Yuki Toyama, Yutaro Shiraishi, Ichio Shimada. Function-Related Dynamics in Multi-Spanning Helical Membrane Proteins Revealed by Solution NMR. Membranes. 2021. 11. 8. 604-604
Mizumura, T., Kondo, K., Kurita, M., Kofuku, Y., Natsume, M., Imai, S., Shiraishi, Y., Ueda, T., Shimada, I. Activation of adenosine A2A receptor by lipids from docosahexaenoic acid revealed by NMR. Science Advances. 2020. 6. 12. eaay8544-eaay8544
Imai, S., Yokomizo, T., Kofuku, Y., Shiraishi, Y., Ueda, T., Shimada, I. Structural equilibrium underlying ligand-dependent activation of β2-adrenoreceptor. Nature Chemical Biology. 2020. 16. 4. 430-439

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MISC (17)：

上田卓見, 幸福裕, 竹内恒, 今井駿輔, 白石勇太郎, 嶋田一夫. 溶液NMR法によるGPCRの活性と直結する動的構造平衡の解明-Function-Related Conformational Dynamics of GPCRs Revealed by Solution NMR-ミニ特集生理学的環境での生体高分子の挙動の観察可能性の追求. 日本結晶学会誌 = Journal of the Crystallographic Society of Japan. 2022. 64. 4. 279-284
白石勇太郎, 夏目芽依, 幸福裕, 今井駿輔, 中田國夫, 水越利巳, 上田卓見, 岩井秀夫, 嶋田一夫. 健康・医療・創薬に貢献する物理系薬学研究の最前線 Gタンパク質共役型受容体のシグナル伝達制御機構の解明. 日本薬学会年会要旨集. 2019. 139年会. 1. 136-136
白石勇太郎, 夏目芽依, 幸福裕, 今井駿輔, 中田國夫, 水越利巳, 上田卓見, 岩井秀夫, 嶋田一夫. 区分同位体標識を用いたβ2アドレナリン受容体のリン酸化によるシグナル制御機構の解明. 日本生化学会大会プログラム・講演要旨集. 2018. 91回. [1P-376]
夏目芽依, 白石勇太郎, 幸福裕, 今井駿輔, 中田國夫, 水越利巳, 上田卓見, 岩井秀夫, 嶋田一夫. β2アドレナリン受容体のリン酸化によるシグナル制御機構の解明. 日本生化学会大会プログラム・講演要旨集. 2018. 91回. [1P-377]
白石勇太郎, 夏目芽依, 幸福裕, 今井駿輔, 中田國夫, 水越利巳, 上田卓見, 岩井秀夫, 嶋田一夫. 区分同位体標識を用いたβ2アドレナリン受容体のリン酸化によるシグナル制御機構の解明. 日本薬学会年会要旨集. 2018. 138年会. 2. 260-260

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Lectures and oral presentations (7)：

Biphasic activation of β-arrestin 1 upon interaction with a GPCR revealed by methyl-TROSY NMR
(The 61st Annual Meeting of the Nuclear Magnetic Resonance Society of Japan 2022)
Biphasic activation of β-arrestin 1 upon interaction with a GPCR revealed by methyl-TROSY NMR
(29th International Conference on Magnetic Resonance in Biological Systems 2022)
Elucidation of the signal regulatory mechanism of G protein-coupled receptors
(2019)
Elucidation of the signal regulatory mechanism of G protein-coupled receptors
(The 139th Annual Meeting of the Pharmaceutical Society of Japan 2019)
Phosphorylation-induced conformation of β2-adrenoceptor related to arrestin recruitment revealed by NMR
(28th International Conference on Magnetic Resonance in Biological Systems 2018)

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Work history (7)：

2024/10 - 現在 Osaka University Graduate School of Pharmaceutical Sciences Specially appointed Lecturer
2020/10 - 2024/09 RIKEN RIKEN Center for Biosystems Dynamics Research Research Scientist
2019/04 - 2020/09 Japan Biological Informatics Consortium Researcher
2018/05 - 2019/03 The University of Tokyo Researcher
2017/04 - 2018/04 Japan Biological Informatics Consortium Researcher

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