Rchr
J-GLOBAL ID:202001006870147982
Update date: Jul. 18, 2022
Masubuchi Nami
マスブチ ナミ | Masubuchi Nami
Affiliation and department:
Research field (4):
Tumor biology
, Cell biology
, Molecular biology
, Hematology and oncology
Research theme for competitive and other funds (2):
- 2021 - 2024 骨髄増殖性腫瘍を引き起こす受容体成熟機構の解明
- 2018 - 2021 骨髄増殖性腫瘍の治療標的分子の探索
Papers (7):
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Nami Masubuchi, Marito Araki, Yinjie Yang, Erina Hayashi, Misa Imai, Yoko Edahiro, Yumi Hironaka, Yoshihisa Mizukami, Yoshihiko Kihara, Hiraku Takei, et al. Mutant calreticulin interacts with MPL in the secretion pathway for activation on the cell surface. Leukemia. 2020. 34. 2. 499-509
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Marito Araki, Yinjie Yang, Misa Imai, Yoshihisa Mizukami, Yoshihiko Kihara, Yoshitaka Sunami, Nami Masubuchi, Yoko Edahiro, Yumi Hironaka, Satoshi Osaga, et al. Homomultimerization of mutant calreticulin is a prerequisite for MPL binding and activation. Leukemia. 2019. 33. 1. 122-131
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Hiraku Takei, Yoko Edahiro, Shuichi Mano, Nami Masubuchi, Yoshihisa Mizukami, Misa Imai, Soji Morishita, Kyohei Misawa, Tomonori Ochiai, Satoshi Tsuneda, et al. Skewed megakaryopoiesis in human induced pluripotent stem cell-derived haematopoietic progenitor cells harbouring calreticulin mutations. British journal of haematology. 2018. 181. 6. 791-802
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Marito Araki, Yinjie Yang, Nami Masubuchi, Yumi Hironaka, Hiraku Takei, Soji Morishita, Yoshihisa Mizukami, Shin Kan, Shuichi Shirane, Yoko Edahiro, et al. Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms. Blood. 2016. 127. 10. 1307-16
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Nami Masubuchi, Yuichi Shidoh, Shunzo Kondo, Jun Takatoh, Kazunori Hanaoka. Subcellular localization of dystrophin isoforms in cardiomyocytes and phenotypic analysis of dystrophin-deficient mice reveal cardiac myopathy is predominantly caused by a deficiency in full-length dystrophin. Experimental animals. 2013. 62. 3. 211-7
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MISC (2):
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増渕 菜弥, 荒木 真理人, 小松 則夫. 【慢性骨髄性白血病(CML)および骨髄増殖性腫瘍(MPN)診療の最近の進歩】MPNにおけるcalreticulin遺伝子変異の意義. 血液内科. 2021. 82. 3. 339-346
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H. Takei, S. Mano, N. Masubuchi, Y. Mizukami, S. Morishita, M. Imai, Y. Edahiro, Y. Hironaka, M. Nudejima, S. Tsuneda, et al. ESTABLISHMENT OF AN IN VITRO MODEL FOR THE SKEWED MEGAKARYOPOIESIS BY CALRETICULIN MUTATION IN HUMAN CELLS. HAEMATOLOGICA. 2017. 102. 276-276
Lectures and oral presentations (11):
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変異型CALRはMPLと分泌経路で相互作用し細胞表面で活性化を引き起こす
(第81回日本血液学会学術集会 2019)
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変異型CALRによる骨髄増殖性腫瘍の発症メカニズム
(Tokyo 3M Forum 2019 2019)
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分泌経路における変異型分子シャペロンとサイトカイン受容体の会合による細胞の腫瘍化
(第29回日本サイトメトリー学会学術集会 2019)
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calreticulin遺伝子変異による骨髄増殖性腫瘍発症の分子メカニズム
(Forum of Celgene Hematology / Oncology Progress 2018 2018)
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Localization of mutant calreticulin in the Golgi apparatus is required for its oncogenic capacity
(59th ASH Annual Meeting & Exposition 2017)
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Education (3):
- 2010 - 2013 北里大学大学院 理学研究科 生物科学専攻博士後期課程
- 2008 - 2010 北里大学大学院 理学研究科 生物科学専攻博士前期課程
- 2004 - 2008 北里大学 理学部 生物科学科
Professional career (1):
Work history (3):
- 2021/02 - 現在 順天堂大学大学院 医学研究科 骨髄増殖性腫瘍治療薬開発講座 特任助教
- 2020/04 - 2021/01 順天堂大学 医学部内科学教室・血液学講座 非常勤助教
- 2015/07 - 2020/03 順天堂大学大学院 医学研究科血液内科学講座 博士研究員
Association Membership(s) (1):
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