Rchr
J-GLOBAL ID：202001007493170016
Update date: Oct. 19, 2024
Akizuki Kazutoshi
アキヅキ カズトシ | Akizuki Kazutoshi
Affiliation and department：
Job title：
Postdoctoral Fellow
Research field (2)：
Cell biology
, Functional biochemistry
Research keywords (8)：
Cell cycle
, Fission Yeast
, CK1
, シグナル伝達
, CaMキナーゼ/CaMキナーゼホスファターゼ
, 機能生物化学
, プロテインキナーゼ /ホスファターゼ
, リン酸化・脱リン酸化
Research theme for competitive and other funds (4)：
- 2021 - 2024 低毒性がん転移抑制剤開発のための学際研究:アフィニティータグ法による阻害剤の創製
- 2021 - 2024 CaMKIδ経路の病態生化学:糖尿病と悪性乳がんの発症に関わる新規分子機構の解明
- 2021 - 2022 新規がん転移抑制剤の創製を目指した PPM1F 阻害剤の遊走・浸潤阻害活性の評価
- 2017 - 2020 CaMKIδの新規活性化メカニズム及び軟骨形成における生理機能の解明
Papers (10)：
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Sierra N. Cullati, Kazutoshi Akizuki, Yufan Shan, Eric Zhang, Liping Ren, Rodrigo X. Guillen, Lesley A. Turner, Jun-Song Chen, Jose Navarrete-Perea, Zachary C. Elmore, et al. The DNA Damage Repair Function of Fission Yeast CK1 Involves Targeting Arp8, a Subunit of the INO80 Chromatin Remodeling Complex. Molecular and Cellular Biology. 2024. 1-15
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Sierra N. Cullati, Kazutoshi Akizuki, Jun-Song Chen, Jared L. Johnson, Tomer M. Yaron-Barir, Lewis C. Cantley, Kathleen L. Gould. Substrate displacement of CK1 C-termini regulates kinase specificity. Science Advances. 2024. 10. 19
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Kazutoshi Akizuki, Noriyuki Sueyoshi, Isamu Kameshita, Atsuhiko Ishida. Diverse physiological functions of CaMK phosphatase and studies on its inhibitors. Seikagaku. 2023. 95. 5. 676-681
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Kazutoshi Akizuki, Nao Shimoda, Hana Ozaki, Takeshi Yamazaki, Tetsuo Hirano, Yasuhiro Ishihara, Noriyuki Sueyoshi, Isamu Kameshita, Toshiyuki Murai, Atsuhiko Ishida. CaMK phosphatase (CaMKP/POPX2/PPM1F) inhibitors suppress the migration of human breast cancer MDA-MB-231 cells with loss of polarized morphology. Biochemical and Biophysical Research Communications. 2023. 639. 1-8
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Kazutoshi Akizuki, Shun Ishikawa, Rika Obatake, Hana Ozaki, Nao Shimoda, Tatsuo Nehira, Takeshi Yamazaki, Tomoya Kinumi, Jin Osawa, Noriyuki Sueyoshi, et al. CaM kinase phosphatase (CaMKP/PPM1F/POPX2) is specifically inactivated through gallate-mediated protein carbonylation. Archives of Biochemistry and Biophysics. 2022. 720. 109170-109170
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MISC (1)：
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Sierra N. Cullati, Kazutoshi Akizuki, Jun-Song Chen, Kathleen L. Gould. Substrate displacement of CK1 C-termini regulates kinase specificity. 2023
Books (1)：
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基礎化学実験(改訂第7版)
大学教育出版 2022
Lectures and oral presentations (33)：
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Natural polyphenol compounds with pyrogallol structure specifically inactivate CaM kinase phosphatase (CaMKP/PPM1F/POPX2) by protein carbonylation
(第65回 日本生化学会中国四国支部例会 2024)
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CaMキナーゼホスファターゼの新規蛍光基質PoLys-CUPの開発
(第65回 日本生化学会中国四国支部例会 2024)
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Mitotic hyperphosphorylation of the Schizosaccharomyces pombe CK1, Hhp2
(Department of Cell & Developmental Biology, 21st Annual Retreat 2024)
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Analyses of the mitotic phosphorylation of the Schizosaccharomyces pombe CK1, Hhp2
(11th International Fission Yeast Meeting POMBE 2023 2023)
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ヒト乳がん細胞の遊走における CaM キナーゼホスファターゼの機能的役割
(第43回 日本分子生物学会年会 2022)
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Education (3)：
- 2017 - 2020 Ehime University The United Graduate School of Agricultural Sciences Applied Bioresource Sciences
- 2015 - 2017 Kagawa University Graduate School of Agriculture
- 2011 - 2015 Kagawa University Faculty of Agriculture Department of Applied Biological Science
Professional career (1)：
Work history (3)：
- 2022/09 - 現在 Vanderbilt University School of Medicine Basic Science Postdoctoral Fellow
- 2020/04 - 2022/08 Hiroshima University Graduate School of Integrated Sciences for Life Assistant Professor
- 2017/04 - 2020/03 日本学術振興会特別研究員 (DC1)(愛媛大学)
Awards (2)：
- 2018/09 - 2018年度 日本農芸化学会中四国支部 優秀発表賞
- 2018/06 - Travel Grant Award of the IUBMB SEOUL 2018
Association Membership(s) (2)：
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