Yoshitomi Hideyuki

2017 - 2020 Identification of biomarkers for biliary tract cancer by proteomic approaches

2016 - 2019 Elucidation of the role of KLF5, 17 in metastatic cascade of gastrointestinal cancer

2016 - 2019 Expression of annexin II and stromal tenascin C promotes epithelial to mesenchymal transition and correlates with distant metastasis in pancreatic cancer

2015 - 2018 Elucidation of molecular mechanism for pancreato-biliary cancer progression through EMT plasticity

2015 - 2018 New criteria of pancreatic neuroendocrine tumors depending on expression levels of transcription factors related to neural and endocrine cell development

2014 - 2017 Identification of novel biomarkers for pancreato-biliary cancer by comprehensive protein profiling analysis

2013 - 2016 The kinetics and modulation of tumor-initiating cells regulated by cell differentiation and dedifferentiation in de novo primary liver cancer

2012 - 2015 Identification of drug resistance-related proteins in pancreatic cancer by SILAC quantitative proteomic approach.

2012 - 2015 Development of a new treatment for small-for-size liver graft injury after living donor liver transplantation by bone morphogenetic protein (BMP)-7.

2012 - 2015 Identification of pancreatic cancer stem cells and its interaction with surrouding stroma

2011 - 2012 Molecular mechanisms of tumorigenesis of enteric and pancreatic neuroendocrine tumor and development of new molecular targeting therapy.

2010 - 2012 Clinical heterogeneity brought about by tumor-initiating cells in primary liver cancer and the development of new therapeutic strategy by regulating microRNAs.

2010 - 2011 Development of a diagnostic marker and method for pancreatic cancer using secretome and proteome analysis.

2009 - 2011 Interacti on between mesenchymal and cancer stem cells in pancreatic cancer

2008 - 2010 Promotion of Liver Regeneration and Control of Infectious Complications after Liver Transplantation and Major Hepatectomy.

2008 - 2010 Functional analysis and clinical application for ApoC-1 in patients with pancreatic cancer

2008 - 2010 The personalized therapy using Annexin II as a gemcitabine-resistant factor for pancreatic cancer patients after surgery.

2007 - 2008 Mechanistic investigation for hepatic schemia/reperfusion injury and promising modality of prevention for organ failure

2007 - 2008 MicroRNAs and their potential for cancer development inhepatocellular and cholangiocellular carcinomas derived fromhepatic progenitor cells.

2007 - 2008 Mechanismsoftheinteractionbetweencancercells andmesenchymal Cells in gastroirltestinal cancer.

2006 - 2007 Proteomicsによる胆道・膵癌新規抗癌剤耐性因子の解明と臨床応用の可能性

2006 - 2007 Identification of specific pancreatic serum protein marker for early diagnosis by using ProteinChip technology

2005 - 2006 Development of new therapy targeting against factors specifically expressed in vessels of cancerous tissues for cancer of digestive system

2005 - 2006 Investigation for gene transfer regulation of organ failure induced by hepatic ischemia/reperfusion injury

2005 - 2006 Clarification of pathogenesis and development of therapeutic strategy for small-for size syndrome after major hepatectomy in biliary tract cancer

2004 - 2005 Identification of factors involving chemotherapy resistance in pancreatic cancer patients by Protein Chip system for developing prediction system of chemotherapy response.