Ishizaki Takahiro

Affiliation and department：
Job title： Lecturer

Research field (2)： Molecular biology , Parasitology

Research keywords (6)： Erythrocyte Invasion Mechanism , Gene Editing , Molecular Parasitology , haemoprotozoan , Babesia , Plasmodium

Research theme for competitive and other funds (7)：

2023 - 2024 ウシバベシア原虫赤内期必須遺伝子の同定に向けた次世代型CRISPRスクリーニング基盤の構築
2021 - 2023 Elucidation of the sensing mechanism in malaria parasite that play a role in host environment adaptation
2021 - 2023 分裂体期脂質転換酵素による新規『遅延死』モデルの構築
2020 - 2022 Elucidation of the DGK regulated erythrocyte invasion mechanism of malaria parasites
2019 - 2022 Signaling mechanism of the apical organelle discharge by malaria parasites during erythrocyte invasion

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Papers (14)：

Thorey K Jonsdottir, Martina S Paoletta, Takahiro Ishizaki, Sophia Hernandez, Maria Ivanova, Alicia Herrera Curbelo, Paulina A Saiki, Martin Selinger, Debojyoti Das, Johan Henriksson, et al. A scalable CRISPR-Cas9 gene editing system facilitates CRISPR screens in the malaria parasite Plasmodium berghei. bioRxiv. 2024
T. Ishizaki, S. Hernandez, M.S. Paoletta, T. Sanderson, E.S.C. Bushell. CRISPR/Cas9 and genetic screens in malaria parasites: small genomes, big impact. Biochemical Society Transactions. 2022
Hassan Hakimi, Masahito Asada, Takahiro Ishizaki, Shinichiro Kawazu. Isolation of viable Babesia bovis merozoites to study parasite invasion. Scientific Reports. 2021. 11. 1. 16959-16959
Nattawat Chaiyawong, Takahiro Ishizaki, Hassan Hakimi, Masahito Asada, Kazuhide Yahata, Osamu Kaneko. Distinct effects on the secretion of MTRAP and AMA1 in Plasmodium yoelii following deletion of acylated pleckstrin homology domain-containing protein. Parasitology International. 2021. 102479-102479
Takahiro Ishizaki, Masahito Asada, Hassan Hakimi, Nattawat Chaiyawong, Yuto Kegawa, Kazuhide Yahata, Osamu Kaneko. cAMP-dependent protein kinase regulates secretion of apical membrane antigen 1 (AMA1) in Plasmodium yoelii. Parasitology International. 2021. 85. 102435-102435

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MISC (1)：

Books (1)：

Lectures and oral presentations (25)：

DGKが制御するマラリア原虫生活環
(第1回Transformative Life Science Meeting 2024)
Plasmodium yoelii diacylglycerol kinases are required for the merozoite invasion and blood stage development
(2024)
Phenotypic assessment of pseudokinase pPK3 and pPK4 knockout lines in Plasmodium yoelii
(2023)
The critical role of Pleckstrin Homology domain-containing protein 1 (PH1) during the asexual blood stages of Plasmodium yoelii
(2023)
High-throughput gene editing system enables CRISPR screens in Plasmodium berghei.
(XXXIV Molecular Parasitology Meeting 2023)

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Education (2)：

2016 - 2020 Nagasaki University Graduate School of Biomedical Sciences
2010 - 2016 Obihiro University of Agriculture and Veterinary Medicine Faculty of Animal Husbandry

Professional career (2)：

Work history (9)：

2023/12 - 現在 College of Veterinary Medicine, Rakuno Gakuen University Unit of Medical Zoology Lecturer
2021/04 - 現在 National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine Collaborative researchers
2021/04 - 2023/11 Institute of Tropical Medicine (NEKKEN), Nagasaki University Department of Protozoology Visiting fellow
2021/05 - 2023/10 Molecular Infection Medicine Sweden (MiMS), Umeå University Department of Molecular Biology Postdoctoral stipend
2021/05 - 2023/10 Japan Society for the Promotion of Science Overseas Research Fellow

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Awards (4)：

2023/03 - 日本寄生虫学会第32回奨励賞マラリア原虫の偽キナーゼpPK1に関する研究
2022/03 - The Marine Biological Laboratory Scholarship award for the program Biology of Parasitism
2021/02 - Alumni Association of Institute of Tropical Medicine Incentive award A novel Plasmodium yoelii pseudokinase, PypPK1, is involved in erythrocyte invasion and exflagellation center formation.
2018/04 - Wellcome Genome Campus Advanced Courses and Scientific Conferences WGC Advanced Courses Travel award

Association Membership(s) (1)：

日本寄生虫学会

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