Rchr
J-GLOBAL ID:202001008027717672   Update date: Sep. 05, 2022

Yamashita Takuma

Yamashita Takuma
Affiliation and department:
Research theme for competitive and other funds  (5):
  • 2022 - 2024 ゲノム編集細胞におけるオフターゲット変異の高感度検出法ClAmp-seqの確立
  • 2022 - 2023 RNA製品の品質・安全性評価法の確立
  • 2022 - 2023 遺伝子治療用製品の設計/製造方法変更に伴う品質・安全性評価に関する研究
  • 2020 - 2022 ゲノム編集に伴い意図せず編集されうる塩基配列条件の解明
  • 2017 - 2019 RNA医薬のデリバリーを目的とした標的指向性RNA封入エキソソームの開発
Papers (5):
  • Takuma Yamashita, Haruka Shinotsuka, Yuki Takahashi, Kana Kato, Makiya Nishikawa, Yoshinobu Takakura. SELEX-Based Screening of Exosome-Tropic RNA. Biological and Pharmaceutical Bulletin. 2017. 40. 12. 2140-2145
  • Takuma Yamashita, Yuki Takahashi, Makiya Nishikawa, Yoshinobu Takakura. Effect of exosome isolation methods on physicochemical properties of exosomes and clearance of exosomes from the blood circulation. European Journal of Pharmaceutics and Biopharmaceutics. 2016. 98. 1-8
  • Masaki Morishita, Yuki Takahashi, Makiya Nishikawa, Kohei Sano, Kana Kato, Takuma Yamashita, Takafumi Imai, Hideo Saji, Yoshinobu Takakura. Quantitative analysis of tissue distribution of the B16BL6-derived exosomes using a streptavidin-lactadherin fusion protein and iodine-125-labeled biotin derivative after intravenous injection in mice. Journal of pharmaceutical sciences. 2015. 104. 2. 705-13
  • Takafumi Imai, Yuki Takahashi, Makiya Nishikawa, Kana Kato, Masaki Morishita, Takuma Yamashita, Akihiro Matsumoto, Chonlada Charoenviriyakul, Yoshinobu Takakura. Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice. Journal of extracellular vesicles. 2015. 4. 1. 26238-26238
  • Mitsuru Ando, Yuki Takahashi, Takuma Yamashita, Mai Fujimoto, Makiya Nishikawa, Yoshihiko Watanabe, Yoshinobu Takakura. Prevention of adverse events of interferon γ gene therapy by gene delivery of interferon γ-heparin-binding domain fusion protein in mice. Molecular Therapy - Methods and Clinical Development. 2014. 1. 14023-14023
MISC (4):
  • Takenori YAMAMOTO, Eriko UCHIDA, Takuma YAMASHITA, Takao INOUE. International Regulatory Trends of the Quality and Safety of Gene Therapy Products and Genetically Modified Cell-based Products. 2022. 53. 2. 72-84
  • Immune responses involved in the efficacy and safety of gene therapy using adeno-associated virus vectors. PHARM TECH JAPAN. 2021. 37. 15. 2645-2651
  • Eriko Uchida, Takuma Yamashita, Ryuichi Ono, Yuki Naito, Task Force for Safety Assessment of Genome Editing Therapy, Takao Inoue. Regulations and Safety Evaluation for Genome Editing Therapy. Pharmaceutical and Medical Device Regulatory Science. 2019. 50. 9. 513-522
  • Takuma Yamashita, Yuki Takahashi, Yoshinobu Takakura. Possibility of Exosome-Based Therapeutics and Challenges in Production of Exosomes Eligible for Therapeutic Application. Biological and Pharmaceutical Bulletin. 2018. 41. 6. 835-842
Lectures and oral presentations  (13):
  • ゲノム編集に伴うオフターゲット変異の予測・評価法に関する研究
    (第8回 次世代を担う若手のためのレギュラトリーサイエンスフォーラム 2022)
  • 陰イオン交換 -UHPLC によるアデノ随伴ウイルスベクターの中空粒子評価法に関する研究
    (第28回日本遺伝子細胞治療学会学術集会 2022)
  • Analysis of candidate off-target mutation sequences to be considered for safety assessment of genome editing with SaCas9
    (2022)
  • Analysis of off-target editing sequences by SaCas9 using low specificity guide RNAs
    (2022)
  • イオン交換超高速液体クロマトグラフィーを用いたアデノ随伴ウイルスベクターの中空粒子の定量評価
    (日本薬学会第142年会 2022)
more...
Education (2):
  • 2015 - 2019 Kyoto University
  • 2009 - 2015 Kyoto University
Professional career (1):
  • Ph.D (Kyoto University)
Work history (5):
  • 2021/04 - 現在 National Institute of Health Sciences Division of Molecular Target and Gene Therapy Products
  • 2019/08 - 2021/03 Japan Agency for Medical Research and Development
  • 2019/08 - 2021/03 National Institute of Health Sciences Division of Molecular Target and Gene Therapy Products Postdoctoral fellow
  • 2019/04 - 2019/07 Kyoto University Graduate School of Pharmaceutical Sciences Postdoctoral fellow
  • 2017/04 - 2019/03 Japan Society for the Promotion of Science Research Fellowship for Young Scientists
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