ishihara tomohiko

Affiliation and department：
Job title：講師

Research field (1)： Neuroscience - general

Research keywords (4)： RNA代謝 , 脊髄小脳変性症 , 筋萎縮性側索硬化症 , 神経変性疾患

Research theme for competitive and other funds (7)：

2021 - 2024 ALSのTDP-43病理多型を規定する遺伝的因子の探索
2017 - 2020 The disease mechanism and biomarker of ALS, the view from TDP-43 alternative splicing
2017 - 2020 Therapeutic strategy for ALS with nucleic acid technology focusing on the vulnerability of TDP-43 autoregulation
2015 - 2017 Elucidation of a mechanism of ALS system selectivity focusing on TDP-43 function in interneurons.
2013 - 2016 Autoreguation of TDP-43 in ALS

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Papers (90)：

Hatano Yuya, Ishihara Tomohiko, Hirokawa Sachiko, Onodera Osamu. SCA6の浸透性に関する研究(Study of penetrance of SCA6). 臨床神経学. 2023. 63. Suppl. S335-S335
Shintaro Tsuboguchi, Yuka Nakamura, Tomohiko Ishihara, Taisuke Kato, Tokiharu Sato, Akihide Koyama, Hideki Mori, Yuka Koike, Osamu Onodera, Masaki Ueno. TDP-43 differentially propagates to induce antero- and retrograde degeneration in the corticospinal circuits in mouse focal ALS models. Acta neuropathologica. 2023
Masahiro Uemura, Sho Kitahara, Taisuke Kato, Hiroaki Nozaki, Shoichiro Ando, Tomohiko Ishihara, Osamu Onodera. Inappropriate interpretation of non-pathogenic HTRA1 variant as pathogenic. Annals of clinical and translational neurology. 2023. 10. 7. 1261-1262
Yuya Hatano, Tomohiko Ishihara, Osamu Onodera. Accuracy of a machine learning method based on structural and locational information from AlphaFold2 for predicting the pathogenicity of TARDBP and FUS gene variants in ALS. BMC Bioinformatics. 2023. 24. 1
Yuya Hatano, Tomohiko Ishihara, Sachiko Hirokawa, Osamu Onodera. Machine Learning Approach for the Prediction of Age-Specific Probability of SCA3 and DRPLA by Survival Curve Analysis. Neurology Genetics. 2023. 9. 3. e200075-e200075

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MISC (59)：

畠野雄也, 畠野雄也, 石原智彦, 小野寺理. 研究手法 MOVA:AlphaFold2によるミスセンスバリアントの効果予測. 遺伝子医学. 2024. 14. 1
坪口晋太朗, 中村由香, 石原智彦, 加藤泰介, 佐藤時春, 小山哲秀, 森秀樹, 小池佑佳, 小野寺理, 小野寺理, et al. TDP-43 differentially propagates to induce degeneration in the motor circuit. Dementia Japan. 2023. 37. 4
畠野雄也, 小野寺理, 石原智彦. 新規遺伝子多型病原性予測法MOVAのEOAD原因遺伝子への適応. Dementia Japan. 2022. 36. 4
小池佑佳, 須貝章弘, 原範和, 伊藤絢子, 横関明男, 石原智彦, 山岸拓磨, 坪口晋太朗, 他田真理, 池内健, et al. 加齢と関連したDNA脱メチル化がTDP-43量の自己調節機構を障害する. Dementia Japan. 2021. 35. 4
小野寺理, 畠野雄也, 石原智彦, 廣川祥子. 運動失調の医療水準,患者QOLの向上に資する研究班 DRPLAとMJD,SCA6の発症年齢とCAGリピート数の分布の比較. 運動失調症の医療水準,患者QOLの向上に資する研究班令和2年度総括・分担研究報告書(Web). 2021

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Association Membership(s) (2)：

日本内科学会 , 日本神経学会

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