Rchr
J-GLOBAL ID：202001008466178460
Update date: Feb. 01, 2024
Kihara Yoshihiko
キハラ ヨシヒコ | Kihara Yoshihiko
Affiliation and department：
Job title：
博士研究員
Research field (1)：
Hematology and oncology
Research keywords (5)：
抗体医療
, 蛋白質の切断
, 細胞内蓄積
, 骨髄増殖性腫瘍
, 造血器腫瘍
Research theme for competitive and other funds (2)：
- 2021 - 2024 変異型CALR蛋白質の切断による骨髄増殖性腫瘍発症の抑止
- 2018 - 2021 Mechanisms governing intracellular accumulation of mutant CALR proteins
Papers (25)：
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Tadaaki Inano, Marito Araki, Soji Morishita, Misa Imai, Yoshihiko Kihara, Maho Okuda, Yinjie Yang, Masafumi Ito, Satoshi Osaga, Hiroyuki Mano, et al. Cell-autonomous megakaryopoiesis associated with polyclonal hematopoiesis in triple-negative essential thrombocythemia. Scientific reports. 2021. 11. 1. 17702-17702
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Nami Masubuchi, Marito Araki, Yinjie Yang, Erina Hayashi, Misa Imai, Yoko Edahiro, Yumi Hironaka, Yoshihisa Mizukami, Yoshihiko Kihara, Hiraku Takei, et al. Mutant calreticulin interacts with MPL in the secretion pathway for activation on the cell surface. Leukemia. 2020. 34. 2. 499-509
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Kihara Yoshihiko, Araki Marito, Yang Yinjie, Imai Misa, Masubuchi Nami, Mizukami Yoshihisa, Morishita Soji, Ohsaka Akimichi, Komatsu Norio. 癌原性を有する変異CALRの蓄積を支配するメカニズム(Mechanisms Governing the Accumulation of Mutant CALR Harboring Oncogenic Property). 順天堂醫事雑誌. 2019. 65. 6. 567-567
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Masubuchi Nami, Araki Marito, Hayashi Erina, Yang Yinjie, Imai Misa, Kihara Yoshihiko, Mizukami Yoshihisa, Hironaka Yumi, Takei Hiraku, Edahiro Yoko, et al. 変異分子シャペロンおよびサイトカイン受容体の関与が細胞形質転換に必要である(Engagement of Mutant Molecular Chaperone and Cytokine Receptor in the Secretary is Required for the Cellular Transformation). 順天堂醫事雑誌. 2019. 65. 6. 572-573
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Mizukami Yoshihisa, Araki Marito, Hayashi Erina, Yang Yinjie, Hironaka Yumi, Kihara Yoshihiko, Masubuchi Nami, Imai Misa, Ohsaka Akimichi, Komatsu Norio. CALRのKDEL配列の喪失およびC末端の陰性荷電から陽性荷電アミノ酸への変化だけでは癌原性は生じない(Loss of KDEL and Conversion from Negatively to Positively Charged Amino Acids at the C-terminus of CALR Was Not Sufficient for the Oncogenicity). 順天堂醫事雑誌. 2019. 65. 6. 580-581
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Patents (2)：
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抗切断型変異CALR-CD3二重特異性抗体及び医薬組成物
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切断型の変異型Calreticulinに結合する抗体、及び骨髄増殖性腫瘍の診断、予防又は治療薬
Lectures and oral presentations (14)：
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Therapeutic potential of an antibody targeting the cleaved form of mutant calreticulin in myeloproliferative neoplasms
(62nd ASH Annual Meeting 2020)
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Therapeutic potential of myeloproliferative neoplasms by antibody targeting mutant calreticulin
(The 82nd Annual Meeting of the Japanese Society of Hematology 2020)
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変異型calreticulin特異的配列によるゴルジ体への局在
(第81回日本血液学会学術集会 2019)
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変異型CALRはMPLと分泌経路で相互作用し細胞表面で活性化を引き起こす
(第81回日本血液学会学術集会 2019)
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抗TfR1抗体による真性多血症内因性赤芽球コロニーの形成阻害
(第81回日本血液学会学術集会 2019)
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Education (3)：
- 2011 - 2015 Nihon University Graduate School of Engineering
- 2009 - 2011 Nihon University Graduate School of Engineering
- 2005 - 2009 Nihon University College of Engineering
Work history (2)：
- 2017/04 - 現在 Juntendo University
- 2015/04 - 2017/03 Nihon University College of Engineering Department of Chemical Biology and Applied Chemistry
Association Membership(s) (1)：
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