Rchr
J-GLOBAL ID:202001008586053997   Update date: Feb. 06, 2024

Shigehiro Tsukasa

シゲヒロ ツカサ | Shigehiro Tsukasa
Affiliation and department:
Job title: 嘱託助教
Research field  (4): Immunology ,  Tumor diagnostics and therapeutics ,  Hematology and oncology ,  Cell biology
Research keywords  (5): Molecular cell biology ,  Drug delivery system ,  Adoptive cell therapy ,  Biotechnology ,  Cancer Immunotherapy
Research theme for competitive and other funds  (4):
  • 2023 - 2025 T/NK前駆細胞を用いたCAR-NK細胞療法の基盤研究
  • 2021 - 2023 Establishment of CAR-T cell therapy utilizing precursor T cell
  • 2020 - 2022 Novel adoptive T cell immunotherapy using induced leukocyte stem cell
  • 2015 - 2017 カベオリン-1に着目したHER2標的治療薬の細胞内動態の解明
Papers (17):
  • Muran Xiao, Shinji Kondo, Masaki Nomura, Shinichiro Kato, Koutarou Nishimura, Weijia Zang, Yifan Zhang, Tomohiro Akashi, Aaron Viny, Tsukasa Shigehiro, et al. BRD9 determines the cell fate of hematopoietic stem cells by regulating chromatin state. Nature Communications. 2023. 14. 1. 8372-8372
  • Tsukasa Shigehiro, Maho Ueno, Mayumi Kijihira, Ryotaro Takahashi, Chiho Umemura, Eman A Taha, Chisaki Kurosaka, Megumi Asayama, Hiroshi Murakami, Ayano Satoh, et al. Immune State Conversion of the Mesenteric Lymph Node in a Mouse Breast Cancer Model. International journal of molecular sciences. 2022. 23. 19
  • Apriliana Cahya Khayrani, Hafizah Mahmud, Aung Ko Ko Oo, Maram H. Zahra, Miharu Oze, Juan Du, Md Jahangir Alam, Said M. Afify, Hagar A. Abu Quora, Tsukasa Shigehiro, et al. Targeting ovarian cancer cells overexpressing cd44 with immunoliposomes encapsulating glycosylated paclitaxel. International Journal of Molecular Sciences. 2019. 20. 5
  • Junko Masuda, Tsukasa Shigehiro. D-mannose suppresses type 1 diabetes and pulmonary airway inflammation by inducing regulatory T cells. Trends in Glycoscience and Glycotechnology. 2018. 30. 177. E239-E240
  • Junko Masuda, Tsukasa Shigehiro, Takuma Matsumoto, Ayano Satoh, Akifumi Mizutani, Chiho Umemura, Shoki Saito, Mayumi Kijihira, Eiji Takayama, Akimasa Seno, et al. Cytokine expression and macrophage localization in xenograft and allograft tumor models stimulated with lipopolysaccharide. International Journal of Molecular Sciences. 2018. 19. 4
more...
MISC (5):
  • Tsukasa Shigehiro. Detection of cancer-reactive t cells using α (1,3) fucosyltransferase. Trends in Glycoscience and Glycotechnology. 2021. 33. 192. E45-E46
  • Apriliana C. Khayrani, Hafizah Mahmud, Tomonari Kasai, Tsukasa Shigehiro, Aung Ko Ko Oo, Juan Du, Md. Jahangir Alam, Koji Hara, Hiroki Hamada, Yuhki Seno, et al. Development of Paclitaxel Glycoside Liposomes Conjugated with Anti-CD44 Antibody Targeting Ovarian Cancer Cells. CANCER SCIENCE. 2018. 109. 1097-1097
  • Shigehiro T, Seno, M. Immunoliposomes: Recent Progress of Liposomal Drug Delivery System Coupled with Antibodies. in “Liposomes: Historical, Clinical and Molecular Perspectives. Liposomes Historical,Clinical and Molecular Perspectives. 2017. 189-209
  • Tsukasa Shigehiro, Tomonari Kasai, Akifumi Mizutani, Hiroshi Murakami, Katsuhiko Mikuni, Tadakatsu Mandai, Hiroki Hamada, Masaharu Seno. Anti-cancer activity of immunoliposomes encapsulated effective amount of glycosylated paclitaxel with novel loading strategy. CANCER RESEARCH. 2014. 74. 19
  • Tsukasa Shigehiro, Tomonari Kasai, Akifumi Mizutani, Hiroshi Murakami, Katsuhiko Mikuni, Tadakatsu Mandai, Hiroki Hamada, Masaharu Seno. A novel remote loading method with solubility gradient to encapsulate effevtive amount of taxanes into liposomes. CANCER RESEARCH. 2013. 73. 8
Patents (2):
  • タキサン化合物を内包するリポソーム
  • パクリタキセルモノグリコシド及び/又はドセタキセルモノグリコシドを内包するリポソームの製造方法
Education (1):
  • 2014 - 2016 Okayama University The Graduate School of Natural Science and Technology
Work history (4):
  • 2020/04 - 現在 Tokyo University of Science
  • 2018/04 - 2020/03 Roswell Park Cancer Institute
  • 2017/04 - 2018/03 University of Michigan, Ann arbor
  • 2016/04 - 2018/03 Japan Society for the Promotion of Science
Awards (3):
  • 2021/09 - 日本血液学会 第83回日本血液学会 優秀ポスター賞
  • 2016/03 - 岡山大学 自然科学研究科長賞
  • 2014/03 - 岡山県 仁科賞
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