Rchr
J-GLOBAL ID：202001008923507261
Update date: Jun. 04, 2024
Kashiwagi Kazuhiro
カシワギ カズヒロ | Kashiwagi Kazuhiro
Affiliation and department：
Job title：
研究員
Research field (1)：
Structural biochemistry
Research keywords (4)：
クライオ電子顕微鏡
, X線結晶構造解析
, 翻訳
, ストレス応答
Research theme for competitive and other funds (2)：
- 2022 - 2025 細胞変性過程における統合的ストレス応答活性化の分子基盤
- 2018 - 2021 Molecular basis of the inhibition of eIF2B under stress
Papers (12)：
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Yuichi Shichino, Tomokazu Yamaguchi, Kazuhiro Kashiwagi, Mari Mito, Mari Takahashi, Takuhiro Ito, Nicholas T Ingolia, Keiji Kuba, Shintaro Iwasaki. eIF4A1 enhances LARP1-mediated translational repression during mTORC1 inhibition. Nature structural & molecular biology. 2024
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Eriko Matsuura-Suzuki, Tadahiro Shimazu, Mari Takahashi, Kaoru Kotoshiba, Takehiro Suzuki, Kazuhiro Kashiwagi, Yoshihiro Sohtome, Mai Akakabe, Mikiko Sodeoka, Naoshi Dohmae, et al. METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance. eLife. 2022. 11
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Toshiaki Hosaka, Takashi Nomura, Minoru Kubo, Takanori Nakane, Luo Fangjia, Shun-Ichi Sekine, Takuhiro Ito, Kazutaka Murayama, Kentaro Ihara, Haruhiko Ehara, et al. Conformational alterations in unidirectional ion transport of a light-driven chloride pump revealed using X-ray free electron lasers. Proceedings of the National Academy of Sciences of the United States of America. 2022. 119. 9
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Kazuhiro Kashiwagi, Yuichi Shichino, Tatsuya Osaki, Ayako Sakamoto, Madoka Nishimoto, Mari Takahashi, Mari Mito, Friedemann Weber, Yoshiho Ikeuchi, Shintaro Iwasaki, et al. eIF2B-capturing viral protein NSs suppresses the integrated stress response. Nature Communications. 2021. 12. 1. 7102-7102
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Alisa F Zyryanova, Kazuhiro Kashiwagi, Claudia Rato, Heather P Harding, Ana Crespillo-Casado, Luke A Perera, Ayako Sakamoto, Madoka Nishimoto, Mayumi Yonemochi, Mikako Shirouzu, et al. ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B. Molecular cell. 2020
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MISC (5)：
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Kazuhiro Kashiwagi, Takuhiro Ito. Switching on stress. Nature Chemical Biology. 2023
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柏木 一宏, 伊藤 拓宏. 統合的ストレス応答における翻訳制御の構造生物学-Structural biology of translation regulation in the integrated stress response-特集 翻訳制御の最前線. 細胞. 2022. 54. 12. 688-691
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柏木一宏, 伊藤拓宏. 立体構造からみた統合的ストレス応答の制御. 実験医学増刊 セントラルドグマの新常識. 2022. 40. 12
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Kazuhiro Kashiwagi, Takuhiro Ito, Shigeyuki Yokoyama. Crystal structure of eukaryotic translation initiation factor 2B. SPring-8 Research Frontiers 2016. 2017. 2016. 23-24
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Kazuhiro Kashiwagi, Takuhiro Ito, Shigeyuki Yokoyama. Structural insight into the eIF2-eIF2B interaction. Acta Crystallographica Section A Foundations and Advances. 2014. 70. a1. C1390-C1390
Lectures and oral presentations (7)：
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ISRIBによる統合的ストレス応答の抑制機構
(第44回日本分子生物学会年会 BINDSワークショップ:AMED-BINDSによるアカデミア創薬研究推進へ向けた取り組み 2021)
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NSs protein of sandfly fever Sicilian virus suppresses the integrated stress response
(EMBL Conference: Protein Synthesis and Translational Control 2021)
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Suppression of the integrated stress response by sandfly fever Sicilian virus NSs protein
(2021)
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Structural basis of eIF2B regulation by eIF2 phosphorylation
(EMBO Workshop: Protein Synthesis and Translational Control 2019)
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Inhibition of eIF2B activity by eIF2 phosphorylation
(2019)
ｍore...
Professional career (1)：
- Ph.D. (The University of Tokyo)
Awards (3)：
- 2023/03 - 理化学研究所 理研梅峰賞 ウイルスタンパク質による統合的ストレス応答抑制の新規機構
- 2016/04 - 2015年度理研研究奨励賞
- 2016/04 - 2015年度CLST研究奨励賞
Association Membership(s) (1)：
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