HISHIKAWA Daisuke

Affiliation and department：
Job title： Senior Assistant Professor

Research field (2)： Medical biochemistry , Molecular biology

Research keywords (3)： Metabolic disease , omega-3 fatty acids , lipid metabolism

Research theme for competitive and other funds (9)：

2024 - 2027 肝代謝の性差の新規制御機構とその意義の解明
2022 - 2025 Involvement of hepatic DHA status in nutrition-responsive metabolic regulation
2021 - 2024 肝臓の糖脂質代謝とNAFLDにおけるマクロファージ由来因子による転写制御の意義
2018 - 2021 Analysis of metabolic adaptation to omega-3 fatty acid deficiency in the liver
2014 - 2017 Analysis of biological function regulated by membrane phospholipid diversity

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Papers (30)：

Yasuhiro Yamamoto, Daisuke Hishikawa, Fumihito Ono. Trpv4-mediated apoptosis of Leydig cells induced by high temperature regulates sperm development and motility in zebrafish. Communications Biology. 2024. 7. 1
Katsuyuki Nagata, Daisuke Hishikawa, Hiroshi Sagara, Masamichi Saito, Sumiko Watanabe, Takao Shimizu, Hideo Shindou. Lysophosphatidylcholine acyltransferase 1 controls mitochondrial reactive oxygen species generation and survival of retinal photoreceptor cells. Journal of Biological Chemistry. 2022. 298. 6. 101958-101958
Hironari Kawai, Yosuke Osawa, Michitaka Matsuda, Tomoyuki Tsunoda, Keisuke Yanagida, Daisuke Hishikawa, Miku Okawara, Yuzuru Sakamoto, Tomonari Shimagaki, Yuriko Tsutsui, et al. Sphingosine-1-phosphate promotes tumor development and liver fibrosis in mouse model of congestive hepatopathy. Hepatology. 2021. 76. 1. 112-125
Fumie Hamano, Kazuaki Matoba, Tomomi Hashidate-Yoshida, Tomoyuki Suzuki, Kiyotake Miura, Daisuke Hishikawa, Takeshi Harayama, Koichi Yuki, Yoshihiro Kita, Nobuo N. Noda, et al. Mutagenesis and homology modeling reveal a predicted pocket of lysophosphatidylcholine acyltransferase 2 to catch Acyl-CoA. The FASEB Journal. 2021. 35. 6. e21501
Daisuke Hishikawa, Keisuke Yanagida, Katsuyuki Nagata, Ayumi Kanatani, Yoshiko Iizuka, Fumie Hamano, Megumi Yasuda, Tadashi Okamura, Hideo Shindou, Takao Shimizu. Hepatic Levels of DHA-Containing Phospholipids Instruct SREBP1-Mediated Synthesis and Systemic Delivery of Polyunsaturated Fatty Acids. iScience. 2020. 23. 9. 101495-101495

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MISC (6)：

長田克之, 菱川大介, 相良洋, 横溝岳彦, 渡辺すみ子, 進藤英雄, 清水孝雄. リゾホスファチジルコリンアシル転移酵素1欠損による視覚機能異常. 脂質生化学研究. 2020. 62. 186-187
長田克之, 菱川大介, 進藤英雄, 横溝岳彦, 清水孝雄. 網膜におけるリゾホスファチジルコリンアシル基転移酵素1の役割. 日本生化学会大会プログラム・講演要旨集. 2019. 92回. [3P-038]
菱川佳子, 飯塚, 菱川大介, 佐々木純子, 田久保圭誉, 後藤元人, 長田克之, 中西広樹, 進藤英雄, 岡村匡史, et al. 生殖における脂質生物学精子形成におけるDHA含有リン脂質の役割. 生命科学系学会合同年次大会. 2017. 2017年度. [1PW24-2]
菱川大介, 進藤英雄, 高祖秀登, 佐々木順子, 中西弘樹, 佐々木雄彦, 渡辺すみ子, 清水孝雄. 網膜視覚科学の最前線網膜視細胞における膜リン脂質組成の意義. 生命科学系学会合同年次大会. 2017. 2017年度. [3PW06-3]
菱川佳子, 飯塚, 菱川大介, 佐々木純子, 田久保圭誉, 後藤元人, 長田克之, 中西広樹, 進藤英雄, 岡村匡史, et al. 精子形成におけるDHA含有リン脂質の役割の解明. 脂質生化学研究. 2017. 59. 89-90

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Education (3)：

2005 - 2009 The University of Tokyo Graduate School of Medicine
2003 - 2005 Shinshu University Department of Food Production Science, Faculty of Agriculture
1999 - 2003 Shinshu University Department of Food Production Science, Faculty of Agriculture

Work history (7)：

2021/04 - 現在 Nippon Medical School Department of Biochemistry and Molecular Biology Senior Assistant Professor
2020/04 - 2021/03 Tokyo Medical and Dental University Institute of Research Project Assistant Professor
2019/08 - 2020/03 National Center for Global Health and Medicine Lipid Signaling Project Research Fellow
2013/08 - 2019/07 National Center for Global Health and Medicine Lipid Signaling Project Senior Research Fellow
2012/04 - 2013/07 National Center for Global Health and Medicine Lipid Signaling Project Research Fellow

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