Yamamoto Naoki

ヤマモトナオキ | Yamamoto Naoki

Affiliation and department：

Research field (1)： Virology

Research theme for competitive and other funds (2)：

2018 - 2021 閉環状DNAとして染色体外に存在するB型肝炎ウイルスゲノムの維持と分解機序の解明
2015 - 2018 Regulation of HBs antigen expression in HBV genotype A infection

Papers (39)：

Hirohito Ishigaki, Fumihiko Yasui, Misako Nakayama, Akinori Endo, Naoki Yamamoto, Kenzaburo Yamaji, Cong Thanh Nguyen, Yoshinori Kitagawa, Takahiro Sanada, Tomoko Honda, et al. An attenuated vaccinia vaccine encoding the severe acute respiratory syndrome coronavirus-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human angiotensin-converting enzyme 2 transgenic mice from severe acute respiratory syndrome coronavirus-2 and its variants. Frontiers in Microbiology. 2022. 13. 967019-967019
Hirohito Ishigaki, Fumihiko Yasui, Misako Nakayama, Akinori Endo, Naoki Yamamoto, Kenzaburo Yamaji, Cong Thanh Nguyen, Yoshinori Kitagawa, Takahiro Sanada, Tomoko Honda, et al. An attenuated vaccinia vaccine encoding the SARS-CoV-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human ACE2 transgenic mice from SARS-CoV-2 and its variants. 2022
Fumihiko Yasui, Yusuke Matsumoto, Naoki Yamamoto, Takahiro Sanada, Tomoko Honda, Tsubasa Munakata, Yasushi Itoh, Michinori Kohara. Infection with the SARS-CoV-2 B.1.351 variant is lethal in aged BALB/c mice. Scientific reports. 2022. 12. 1. 4150-4150
Makoto Saito, Yasushi Itoh, Fumihiko Yasui, Tsubasa Munakata, Daisuke Yamane, Makoto Ozawa, Risa Ito, Takayuki Katoh, Hirohito Ishigaki, Misako Nakayama, et al. Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models. Nature Communications. 2021. 12. 1
Takahiro Sanada, Tomoko Honda, Fumihiko Yasui, Kenzaburo Yamaji, Tsubasa Munakata, Naoki Yamamoto, Makoto Kurano, Yusuke Matsumoto, Risa Kohno, Sakiko Toyama, et al. Serologic survey of IgG against SARS-CoV-2 among hospital visitors without a history of SARS-CoV-2 infection in Tokyo, 2020-2021. Journal of epidemiology. 2021. 32. 2. 105-111

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MISC (18)：

安井文彦, 伊藤靖, 山地賢三郎, 山本直樹, 松本祐介, 真田崇弘, 本田智子, 棟方翼, 石垣宏仁, 仲山美沙子, et al. COVID-19ワクシニアウイルスベクターワクチンの開発. 日本実験動物学会総会講演要旨集(Web). 2022. 69th
ケアシュ・モハメド, 尼子豊, ハシェム・モハメド, 山本直樹, 杉山真也, 溝上雅史, 小原道法, 小原恭子. B型肝炎ウイルスcccDNAを標的としたCRISPR/Cas9システムの生体内送達法の開発. 日本癌学会総会記事. 2021. 80回. [J3-5]
齊藤誠, 伊藤靖, 安井文彦, 棟方翼, 山根大典, 小沢真, 山地賢三郎, 山本直樹, 本田智子, 真田崇弘, et al. Targeted macrocycles hamper hemagglutinin adsorption and fusion, and have antiviral effects in murine and macaque models of influenza. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
高瀬明, 高瀬明, 一宮智美, 岡松正敏, 木下貴明, 木下貴明, 小林大樹, 市居修, 山本直樹, 山本直樹, et al. Receptor structures that contribute to the propagation of human H1N1 influenza A viruses in embryonated chicken eggs. 日本糖質学会年会要旨集. 2021. 40th
安井文彦, 伊藤靖, 石垣宏仁, 仲山美沙子, 山本直樹, 山地賢三郎, CONG Thanh Nguyen, 遠藤彬則, 本田智子, 真田崇弘, et al. 高度弱毒化ワクシニアウイルスDIsを用いたCOVID-19ワクチンの作出と変異株に対する防御効果の検討. 日本ワクチン学会学術集会プログラム・抄録集. 2021. 25th

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Patents (2)：

難治性ウイルス感染症の治療剤
脂質膜構造体

Work history (3)：

2016/04 - 現在 Tokyo Metropolitan Institute of Medical Science
2012/12 - 2016/03 Tokyo Metropolitan Institute of Medical Science
2009/04 - 2012/11 Hokkaido University Graduate School of Veterinary Medicine

Awards (2)：

2013/10 - International HBV Meeting Award of Excellence Poster Presentation ”Establishment of efficient HBV infection and replication system in vitro"
2012/11 - 日本ウイルス学会優秀ポスター賞「非病原性鳥インフルエンザウイルスA/duck/Hokkaido/Vac-1/2004 (H5N1) のニワトリに対する病原性獲得に与るウイルス因子の同定」

Association Membership(s) (3)：

日本肝臓学会 , 日本抗ウイルス療法学会 , 日本ウイルス学会

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