Sakashita Akihiko

サカシタアキヒコ | Sakashita Akihiko

Affiliation and department：

Research field (3)： Developmental biology , Molecular biology , Zoological sciences

Research keywords (8)：全能性制御 , Endogenous Retrovirus , Epigenetics , 種間トランスクリプトーム比較 , Early embryonic development , Retrotransposon , Meiosis , Germ cell development

Research theme for competitive and other funds (8)：

2024 - 2026 個体発生において種間の多様性をもたらす内在性レトロウイルスの機能解析
2023 - 2026 胚発生活性化を担保する着床期胚・子宮内膜間相互作用の解明
2022 - 2025 内在性レトロウイルスを介した全能性制御機構の解明
2022 - 2024 内在性レトロウイルスによる宿主ゲノムのクロマチン再構築機構
2021 - 2023 Epigenetic regulation of ERV-driven enhancer in germline development

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Papers (32)：

Youjia Guo, Tomohiro Kitano, Kimiko Inoue, Kensaku Murano, Michiko Hirose, Ten D Li, Akihiko Sakashita, Hirotsugu Ishizu, Narumi Ogonuki, Shogo Matoba, et al. Obox4 promotes zygotic genome activation upon loss of Dux. eLife. 2024. 13
So Maezawa, Masashi Yukawa, Kazuteru Hasegawa, Ryo Sugiyama, Mizuho Iizuka, Mengwen Hu, Akihiko Sakashita, Miguel Vidal, Haruhiko Koseki, Artem Barski, et al. PRC1 suppresses a female gene regulatory network to ensure testicular differentiation. Cell Death & Disease. 2023. 14. 8
Akihiko Sakashita, Masatoshi Ooga, Kai Otsuka, So Maezawa, Chikara Takeuchi, Sayaka Wakayama, Teruhiko Wakayama, Satoshi H Namekawa. Polycomb protein SCML2 mediates paternal epigenetic inheritance through sperm chromatin. Nucleic Acids Research. 2023
Yamato Fukui, Yasushi Hirota, Shizu Aikawa, Akihiko Sakashita, Ryoko Shimizu-Hirota, Norihiko Takeda, Chihiro Ishizawa, Rei Iida, Tetsuaki Kaku, Tomoyuki Hirata, et al. The EZH2-PRC2-H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion. Cell Death & Disease. 2023. 14. 5
Akihiko Sakashita, Tomohiro Kitano, Hirotsugu Ishizu, Youjia Guo, Harumi Masuda, Masaru Ariura, Kensaku Murano, Haruhiko Siomi. Transcription of MERVL retrotransposons is required for preimplantation embryo development. Nature Genetics. 2023

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MISC (16)：

小林(石原) 美栄, 坂下陽彦, 石津大嗣, 郭又嘉, 北野智大, 有浦勝, 蓮輪英毅, 村野健作, 小迫英尊, 塩見春彦. マウス内在性レトロウイルスLの適切な発現と機能のための因子, Refee. 第47回日本分子生物学会年会要旨集(Web), 3P-611(3PS-01-06). 2024
Transcriptomic Analysis to Identify Divergent Functions of Transposable Elements in Preimplantation Embryos. 2024
中原俊矢, キュリオンフィオナ, 坂下陽彦, 塩見春彦. マウス固有の胎盤発生を制御する内在性レトロウイルスの機能解析. 第47回日本分子生物学会年会要旨集(Web), 3AS-03-02. 2024
Mie Kobayashi-Ishihara, Akihiko Sakashita, Masaru Ariura, Hirotsugu Ishizu, Tomohiro Kitano, Youjia Guo, Hidetoshi Hasuwa, Kensaku Murano, Haruhiko Siomi. REFEE, A Nuclear RNA Binding Protein, Regulates Early Development in Mice. SSCR/JSRM 2021 Tokyo International Symposium. 2021. 120
Akihiko SAKASHITA, Tomohiro KITANO, Hirotsugu ISHIZU, Youjia GUO, Masaru ARIURA, Kensaku MURANO, Haruhiko SIOMI. The Role of Retroelement MERVL in Preimplantation Development. SSCR/JSRM 2021 Tokyo International Symposium. 2021. 108

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Books (3)：

The role of EVE in regulating host gene expression & ontogeny -beyond threats, and be beneficial to host genome integrity-
2023
Mouse embryonic development requires transposable element expression
2023
in vitroにおける個体発生の再構成をめざして
ファルマシア 2023 年 59 巻 6 号 p. 560

Lectures and oral presentations (11)：

マウス初期発生過程における内在性レトロウイルスによるクロマチン再構築機構
(第47回分子生物学会年会, 2AS-03-07; 「全能性細胞におけるエピジェネティック制御機構」 2024)
Retrotransposon-driven Regulatory Landscapes Shape Early Developmental Program in Mammals
(2024)
Exploring the conservation and divergence of transposable element functions during embryonic development in mammals.
(2023)
The Role of Retrotransposon : MERVL in Regulating Host Gene Expression and Ontogeny
(The 2nd international symposium on “Replication of Non-Genome” 2023)
転移因子が駆動する哺乳動物の個体発生
(東海医学会 (東海大学医学部) 2023)

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Education (2)：

2013 - 2017 Tokyo University of Agriculture Graduate School of Agriculture Department of Bio-Science
2008 - 2012 Tokyo University of Agriculture Faculty of Applied Bio-Science Department of Bio-Science

Work history (3)：

2024/04 - 現在 Keio University School of Medicine Department of Molecular Biology Assistant Professor
2020/07 - 2024/03 Keio University School of Medicine Department of Molecular Biology Assistant Professor
2017/06 - 2020/06 Cincinnati Children's Hospital Medical Center Division of Reproductive Sciences Research Fellow

Awards (10)：

2022/01 - 上原記念生命科学財団研究奨励金 (基礎医学)
2021/04 - 加藤記念バイオサイエンス振興財団第32回加藤記念研究助成
2021/03 - Japan Society for Bioscience, Biotechnology and Agrochemistry Award for Excellence to Authors Publishing in Bioscience, Biotechnology, and Biochemistry 2020
2021/03 - United Japanese Reserchers Around the World UJA論文賞特別賞
2019/12 - The Molecular Biology Society of Japan 2019 Foreign Travel Award

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Association Membership(s) (3)：

The Molecular Biology Society of Japan , Society for Reproduction and Development , Japan Society for Ova Research

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