Sakashita Akihiko

サカシタアキヒコ | Sakashita Akihiko

Affiliation and department：

Research field (3)： Developmental biology , Molecular biology , Zoological sciences

Research keywords (8)：全能性制御 , Endogenous Retrovirus , Epigenetics , 種間トランスクリプトーム比較 , Early embryonic development , Retrotransposon , Meiosis , Germ cell development

Research theme for competitive and other funds (8)：

2024 - 2026 個体発生において種間の多様性をもたらす内在性レトロウイルスの機能解析
2023 - 2026 胚発生活性化を担保する着床期胚・子宮内膜間相互作用の解明
2022 - 2025 内在性レトロウイルスを介した全能性制御機構の解明
2022 - 2024 内在性レトロウイルスによる宿主ゲノムのクロマチン再構築機構
2021 - 2023 Epigenetic regulation of ERV-driven enhancer in germline development

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Papers (31)：

So Maezawa, Masashi Yukawa, Kazuteru Hasegawa, Ryo Sugiyama, Mizuho Iizuka, Mengwen Hu, Akihiko Sakashita, Miguel Vidal, Haruhiko Koseki, Artem Barski, et al. PRC1 suppresses a female gene regulatory network to ensure testicular differentiation. Cell Death & Disease. 2023. 14. 8
Akihiko Sakashita, Masatoshi Ooga, Kai Otsuka, So Maezawa, Chikara Takeuchi, Sayaka Wakayama, Teruhiko Wakayama, Satoshi H Namekawa. Polycomb protein SCML2 mediates paternal epigenetic inheritance through sperm chromatin. Nucleic Acids Research. 2023
Yamato Fukui, Yasushi Hirota, Shizu Aikawa, Akihiko Sakashita, Ryoko Shimizu-Hirota, Norihiko Takeda, Chihiro Ishizawa, Rei Iida, Tetsuaki Kaku, Tomoyuki Hirata, et al. The EZH2-PRC2-H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion. Cell Death & Disease. 2023. 14. 5
Akihiko Sakashita, Tomohiro Kitano, Hirotsugu Ishizu, Youjia Guo, Harumi Masuda, Masaru Ariura, Kensaku Murano, Haruhiko Siomi. Transcription of MERVL retrotransposons is required for preimplantation embryo development. Nature Genetics. 2023
Daiki Shikata, Shogo Matoba, Masashi Hada, Akihiko Sakashita, Kimiko Inoue, Atsuo Ogura. Suppression of endogenous retroviral enhancers in mouse embryos derived from somatic cell nuclear transfer. Frontiers in Genetics. 2022. 13

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MISC (13)：

Mie Kobayashi-Ishihara, Akihiko Sakashita, Masaru Ariura, Hirotsugu Ishizu, Tomohiro Kitano, Youjia Guo, Hidetoshi Hasuwa, Kensaku Murano, Haruhiko Siomi. REFEE, A Nuclear RNA Binding Protein, Regulates Early Development in Mice. SSCR/JSRM 2021 Tokyo International Symposium. 2021. 120
Akihiko SAKASHITA, Tomohiro KITANO, Hirotsugu ISHIZU, Youjia GUO, Masaru ARIURA, Kensaku MURANO, Haruhiko SIOMI. The Role of Retroelement MERVL in Preimplantation Development. SSCR/JSRM 2021 Tokyo International Symposium. 2021. 108
坂本瑞季, 伊藤大祐, 井上怜, 楊力, 菊池康之, 多田羅麻由, 若山清香, SHARIF Jafar, 坂下陽彦, 前澤創, et al. 精子完成プロセスは胚性ゲノム活性化時のトランスクリプトームに影響する. 日本繁殖生物学会講演要旨集(Web). 2021. 114th
大木淳子, 大木淳子, 坂下陽彦, 稲葉明彦, 粟飯原永太郎, 内山博允, 松本征仁, 二ノ宮裕三, 二ノ宮裕三, 山根拓実, et al. 腸管オルガノイドと生体腸組織における内分泌細胞の比較. 日本農芸化学会大会講演要旨集(Web). 2019. 2019
小林久人, 小池佐, 坂下陽彦, 隈本宗一郎, 神尾明日香, 河野友宏. マウス胚発生過程における片親性DNAメチル化の継承とリプログラミングの全容解明. エピゲノムはどこまで操れるようになったか第11回日本エピジェネティクス研究会年会プログラム集理研シンポジウム平成29年. 2017

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Books (3)：

The role of EVE in regulating host gene expression & ontogeny -beyond threats, and be beneficial to host genome integrity-
2023
Mouse embryonic development requires transposable element expression
2023
in vitroにおける個体発生の再構成をめざして
ファルマシア 2023 年 59 巻 6 号 p. 560

Lectures and oral presentations (9)：

Exploring the conservation and divergence of transposable element functions during embryonic development in mammals.
(2023)
The Role of Retrotransposon : MERVL in Regulating Host Gene Expression and Ontogeny
(The 2nd international symposium on “Replication of Non-Genome” 2023)
転移因子が駆動する哺乳動物の個体発生
(東海医学会 (東海大学医学部) 2023)
Regulation of host gene expression and cell fate by endogenous retrovirus during early stage of embryonic development
(The 1st international symposium of Non-Genome Replication 2022)
Regulation of host gene expression and cell fate by interspersed endogenous retrovirus-L elements during early stage of embryonic development
(2022)

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Education (2)：

2013 - 2017 Tokyo University of Agriculture Graduate School of Agriculture Department of Bio-Science
2008 - 2012 Tokyo University of Agriculture Faculty of Applied Bio-Science Department of Bio-Science

Work history (3)：

2024/04 - 現在 Keio University School of Medicine Department of Molecular Biology Assistant Professor
2020/07 - 2024/03 Keio University School of Medicine Department of Molecular Biology Assistant Professor
2017/06 - 2020/06 Cincinnati Children's Hospital Medical Center Division of Reproductive Sciences Research Fellow

Awards (10)：

2022/01 - 上原記念生命科学財団研究奨励金 (基礎医学)
2021/04 - 加藤記念バイオサイエンス振興財団第32回加藤記念研究助成
2021/03 - Japan Society for Bioscience, Biotechnology and Agrochemistry Award for Excellence to Authors Publishing in Bioscience, Biotechnology, and Biochemistry 2020
2021/03 - United Japanese Reserchers Around the World UJA論文賞特別賞
2019/12 - The Molecular Biology Society of Japan 2019 Foreign Travel Award

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Association Membership(s) (3)：

The Molecular Biology Society of Japan , Society for Reproduction and Development , Japan Society for Ova Research

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