Rchr
J-GLOBAL ID：202001009386086927
Update date: Feb. 01, 2024
Saito Yuhki
サイトウ ユウキ | Saito Yuhki
Affiliation and department：
Job title：
Research Assistant Professor
Research field (4)：
Tumor biology
, Neuroscience - general
, Systems genomics
, Molecular biology
Research theme for competitive and other funds (3)：
- 2011 - 2012 Conformational change of X11L and its physiological functions
- 2009 - 2010 Analysis of X11 proteins functions in vivo
- 2008 - 2008 脳特異的アダプター蛋白質X11およびX11Lの機能解析
Papers (27)：
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Keiko Honda, Yuhki Saito, Haruka Saito, Megumi Toyoda, Ruriko Abe, Takashi Saito, Takaomi C Saido, Makoto Michikawa, Hidenori Taru, Yuriko Sobu, et al. Accumulation of amyloid-β in the brain of mouse models of Alzheimer's disease is modified by altered gene expression in the presence of human apoE isoforms during aging. Neurobiology of aging. 2023. 123. 63-74
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Naoya Gotoh, Yuhki Saito, Saori Hata, Haruka Saito, Daiki Ojima, Chiaki Murayama, Mayo Shigeta, Takaya Abe, Daijiro Konno, Fumio Matsuzaki, et al. Amyloidogenic processing of amyloid β protein precursor (APP) is enhanced in the brains of Alcadein α-deficient mice. The Journal of biological chemistry. 2020. 295. 28. 9650-9662
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Yuhki Saito, Yuan Yuan, Ilana Zucker-Scharff, John J Fak, Saša Jereb, Yoko Tajima, Donny D Licatalosi, Robert B Darnell. Differential NOVA2-Mediated Splicing in Excitatory and Inhibitory Neurons Regulates Cortical Development and Cerebellar Function. Neuron. 2019. 101. 4. 707-720
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Rika Motodate, Haruka Saito, Yuriko Sobu, Saori Hata, Yuhki Saito, Tadashi Nakaya, Toshiharu Suzuki. X11 and X11-like proteins regulate the level of extrasynaptic glutamate receptors. Journal of neurochemistry. 2019. 148. 4. 480-498
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Yuan Yuan, Shirley Xie, Jennifer C Darnell, Andrew J Darnell, Yuhki Saito, Hemali Phatnani, Elisabeth A Murphy, Chaolin Zhang, Tom Maniatis, Robert B Darnell. Cell type-specific CLIP reveals that NOVA regulates cytoskeleton interactions in motoneurons. Genome biology. 2018. 19. 1. 117-117
ｍore...
MISC (5)：
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山本 融, 後藤 直也, 齋藤 有紀, 村山 千明, 鈴木 利治. アルカデインはX11Lと協働して内在性APPのアミロイド産生的代謝を抑制する. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [1P1235]-[1P1235]
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Yuhki Saito, Tsuyoshi Inoue, Toshiharu Suzuki. Malfunction of HCN channels in X11(-/-); X11L(-/-) mice and Alzheimer's disease model mice. NEUROSCIENCE RESEARCH. 2011. 71. E187-E187
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Tohru Yamamoto, Naoya Gotoh, Yuhki Saito, Saori Hata, Fumio Matsuzaki, Toshiharu Suzuki. Amyloidogenic processing of APP is enhanced in Alcadein alpha-deficient mice. NEUROSCIENCE RESEARCH. 2011. 71. E85-E85
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塩野 真希, 穐山 麻由, 山本 融, 斉藤 有紀, 鈴木 利治. APP代謝と細胞内局在に果たすX11Lの機能ドメインの解析. 日本生化学会大会プログラム・講演要旨集. 2009. 82回. 4P-553
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Yuhki Saito, Yoshitake Sano, Tadashi Nakaya, Shigeyoshi Itohara, Toshiharu Suzuki. The roles of X11 and X11L in APP metabolism. NEUROSCIENCE RESEARCH. 2007. 58. S117-S117
Lectures and oral presentations (5)：
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Cell-type specific functional protein-RNA interaction in the brain
(Public seminar at Rockefeller University 2020)
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A RNA-binding protein plays differential biological roles in different neuron
(2019)
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Decoding cell-specific functional protein:RNA interactions in the mammalian brain
(Special Seminar Speaker in Center for NeuroGenetics and Department of Molecular Genetics & Microbiology at University of Florida 2018)
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Neuronal activity and Alzheimer's disease.
(2012)
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The function of X11-like protein on APP metabolism in brain
(2010)
Education (3)：
- 2006 - 2009 Hokkaido University Graduate School of Life Science
- 2004 - 2006 Hokkaido University
- 2000 - 2004 Hokkaido University
Work history (6)：
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