Susukida Takeshi

ススキダタケシ | Susukida Takeshi

Affiliation and department：
Homepage URL (2)： https://www.inm.u-toyama.ac.jp/resercher/susukida/ , https://www.inm.u-toyama.ac.jp/en/resercher/susukida/

Research field (1)： Clinical pharmacy

Research keywords (3)： HLA , Cancer immunity , Idiosyncratic drug toxicity

Research theme for competitive and other funds (9)：

2024 - 2027 免疫細胞のエネルギー代謝環境に着目したHLA多型の関与する薬物過敏症の発症機序解明
2022 - 2025 帯電性ナノバブルによる胸膜播種抑制効果の研究
2024 - 2025 HLA と相互作用する和漢薬を用いた新規がん免疫療法の確立
2023 - 2025 Exploring environmental factors contributing to individual differences in the onset of HLA-related drug-induced hypersensitivity
2021 - 2024 薬物-HLA相互作用による腫瘍免疫原性の改善を利用した低免疫原性腫瘍に対する新規治療法の開発

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Papers (17)：

Akira Kazaoka, Sota Fujimori, Yushiro Yamada, Tomohiro Shirayanagi, Yuying Gao, Saki Kuwahara, Naoki Sakamoto, Takeshi Susukida, Shigeki Aoki, Kousei Ito. HLA-B*57:01-dependent intracellular stress in keratinocytes triggers dermal hypersensitivity reactions to abacavir. PNAS nexus. 2024. 3. 4. pgae140
Nguyen Tien Dung, Takeshi Susukida, Sisca Ucche, Ka He, So-Ichiro Sasaki, Ryuji Hayashi, Yoshihiro Hayakawa. Calorie Restriction Impairs Anti-Tumor Immune Responses in an Immunogenic Preclinical Cancer Model. Nutrients. 2023. 15. 16
Eiji Kobayashi, Yusuke Kamihara, Miho Arai, Akinori Wada, Shohei Kikuchi, Ryo Hatano, Noriaki Iwao, Takeshi Susukida, Tatsuhiko Ozawa, Yuichi Adachi, et al. Development of a Novel CD26-Targeted Chimeric Antigen Receptor T-Cell Therapy for CD26-Expressing T-Cell Malignancies. Cells. 2023. 12. 16
Takeshi Susukida, So-Ichiro Sasaki, Tomohiro Shirayanagi, Shigeki Aoki, Kousei Ito, Yoshihiro Hayakawa. Drug-induced altered self-presentation increases tumor immunogenicity. Biomedicine & pharmacotherapy. 2023. 165. 115241-115241
Shohei Kikuchi, Akinori Wada, Yusuke Kamihara, Kosuke Okazaki, Paras Jawaid, Mati Ur Rehman, Eiji Kobayashi, Takeshi Susukida, Tomoki Minemura, Yoshimi Nabe, et al. DPP8 Selective Inhibitor Tominostat as a Novel and Broad-Spectrum Anticancer Agent against Hematological Malignancies. Cells. 2023. 12. 7

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MISC (48)：

山口叶大, 関戸景子, 薄田健史, 佐々木宗一郎, 早川芳弘. 十全大補湯投与による担がんマウスにおける腸内細菌叢変化と免疫薬理作用の解析. 和漢医薬学会学術大会要旨集. 2024. 41回. 115-115
SHUN Shiyori, SHUN Shiyori, 薄田健史, 白柳智弘, 青木重樹, 伊藤晃成, 早川芳弘. Development of a novel cancer immunotherapy based on tumor immunogenicity improvement by carbamazepine and HLA-B^*15:02 interaction. 日本薬学会年会要旨集(Web). 2024. 144th
薄田健史, SUN Yuchen, 青木重樹, 伊藤晃成, 早川芳弘. An important role of glycolysis in CD8⁺ T cells in the onset of HLA-mediated idiosyncratic drug toxicity. 日本薬学会年会要旨集(Web). 2024. 144th
山口叶大, 薄田健史, 佐々木宗一郎, 早川芳弘. 十全大補湯の免疫調節作用による抗PD-1抗体の抗腫瘍効果の増強(Immuno-modulatory effect of Juzen-taiho-to enhances the effect of anti-PD-1 therapy). 日本癌学会総会記事. 2023. 82回. 764-764
佐々木宗一郎, 薄田健史, 早川芳弘. 骨転移したマウス乳がん細胞の腫瘍増殖に対する骨微小環境の寄与(Bone microenvironment contributes to the proliferation of breast cancer cells in a mouse model of bone metastasis). 日本癌学会総会記事. 2023. 82回. 1780-1780

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Lectures and oral presentations (4)：

Intracellular Glycolysis Levels in CD8+ T cells Affect the Susceptibility to HLA-Mediated Abacavir-induced skin toxicity
(FoPPS Seminar Series, University of Alberta 2024)
Cancer immunotherapy based on tumor immunogenicity improvement by HLA-drug interaction
(2023 China-Japan Youth Exchange Program in Science, Technology and Humanities, Zhejiang Chinese Medical University 2023)
A Novel Strategy for Cancer Immunotherapy Based on Tumor Immunogenicity Improvement by HLA-Drug Interaction
(FoPPS Seminar Series, University of Alberta 2022)
サンドイッチ培養肝細胞を用いた薬剤性胆汁うっ滞型肝障害発症リスク予測法
(医療薬学フォーラム2016 / 第24回クリニカルファーマシーシンポジウム 2016)

Education (3)：

2015 - 2019 Chiba University Graduate School of Pharmaceutical Sciences Ph.D. course
2013 - 2015 Chiba University Graduate School of Pharmaceutical Sciences M.Sc course
2009 - 2013 Chiba University Faculty of Pharmaceutical Sciences

Professional career (1)：

Work history (3)：

2020/04 - 現在 University of Toyama
2019/04 - 2020/03 Japan Society for the Promotion of Science Overseas Research Fellow
2017/04 - 2019/03 Japan Society for the Promotion of Science Research Fellow

Committee career (2)：

Awards (9)：

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Association Membership(s) (6)：

Japanese Association of Cancer Immunology , 日本免疫毒性学会 , 日本薬学会 , 日本毒性学会 , 日本癌学会 , 日本薬物動態学会

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